Overactive bladder

This trial compares two non-invasive treatments for overactive bladder (OAB): transcutaneous peroneal electrical neuromodulation, which uses surface electrodes to stimulate a nerve in the leg, and pelvic floor exercises, a standard behavioral therapy. Adults with idiopathic OAB w…

This phase 3 trial is testing a wearable device that stimulates a nerve in the calf to see if it can reduce the sudden, urgent need to urinate that defines overactive bladder. About 290 adults with overactive bladder symptoms will be randomly assigned to use the device daily or t…

This trial tests three 8-week approaches for women with overactive bladder: standard education on pelvic floor exercises, biofeedback-assisted training, and biofeedback combined with tibial nerve stimulation. The goal is to see if adding biofeedback or nerve stimulation provides …

This study compares two common medications for overactive bladder (OAB): solifenacin, which blocks nerve signals in the bladder, and mirabegron, which helps the bladder muscle relax. Researchers want to see if a person's 'anticholinergic burden'—the combined effect of other medic…

This study tests whether mirabegron, a drug used for overactive bladder, can help people with dry age-related macular degeneration (AMD). Researchers will give 312 patients aged 50-80 either mirabegron or a standard bladder drug for 12 months and check for changes in the retina. …

This study follows 16 people who already received EG110A, a gene therapy that uses a modified herpes virus to deliver a botulinum toxin-like protein to relax bladder muscles. Researchers will track side effects and how well the treatment works over five years. The goal is to see …

This trial tests a treatment called peroneal electric transcutaneous neuromodulation, or peroneal eTNM, for people with overactive bladder syndrome. The procedure uses mild electrical pulses to stimulate the peroneal nerve near the ankle, which may help reduce the sudden, strong …

This pilot trial tests whether a non-invasive nerve stimulation technique, called transcutaneous tibial nerve stimulation (TTNS), can help people with spinal cord injuries who have overactive bladder muscles. Participants will use a small device to deliver mild electrical pulses …

This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve bladder control in people who have had a stroke. Participants will receive either real or sham tDCS alongside standard pelvic floor muscle training, thr…

This study tests whether low-intensity shock wave therapy, a non-surgical treatment applied over the lower abdomen, can ease overactive bladder symptoms in women who haven't found relief from standard treatments. Forty women will be randomly assigned to receive either the real th…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This study tests two treatments—mirabegron (a drug) and exercise-based behavioral therapy—for overactive bladder in people with Parkinson's disease. Researchers want to see if combining treatments helps those who don't respond to one alone. The trial will involve 146 participants…

This study tests whether applying mild electrical pulses (TENS) to the shins can reduce pain and anxiety in people receiving Botox injections into the bladder for overactive bladder. Participants are randomly assigned to receive either active TENS or a sham device during the inje…

This study tests whether stimulating a nerve near the ankle, called percutaneous tibial nerve stimulation (PTNS), can safely treat overactive bladder in children aged 5 to 21. The treatment uses a device called Urgent PC that sends weak electrical signals through a thin needle to…

This study will test whether a wearable device that stimulates a nerve in the leg can help women with overactive bladder and frequent nighttime urination. Participants will either use the device plus behavioral therapy or behavioral therapy alone. The goal is to see if the device…

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This study tests a device called Tensi+ that uses mild electrical pulses to a nerve in the ankle to treat overactive bladder symptoms like sudden urges and frequent bathroom trips. About 60 adults with these symptoms will use the device at home for 12 weeks. The goal is to see if…

This study tests whether a small, portable nerve stimulation device worn at home can reduce urgent bathroom trips in people with overactive bladder. Sixty adults aged 18 to 65 will either use the device during daily life when they feel urgency or receive standard clinic-based ses…

This study compares two non-invasive treatments—magnetic field therapy and tibial nerve stimulation—for women with urge urinary incontinence (sudden, strong urges to urinate leading to leaks). Forty women will be randomly assigned to one of the two treatments over six weeks. Rese…

This study looks at whether a new device (Neuspera SNM System) works better than older devices for people with sudden, strong urges to urinate. About 100 adults who already have a traditional bladder control device will get the new one and answer questions about their symptoms. T…

This study tests whether adding gabapentin to the standard drug solifenacin works better than solifenacin alone for women with overactive bladder. Sixty women will be randomly assigned to one of the two treatments and followed for 3 months. The goal is to see if the combination i…

This study tests a new treatment called TRG-200 KIT for people with overactive bladder (OAB) who haven't found relief from standard therapies. The treatment is given once a month through a catheter into the bladder and slowly releases medication to reduce urgent bathroom trips an…

This study tests whether a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will receive either the gas plus standard numbing medicine or a sham mask plus standard care. Participa…

This study tests if a gentle heat treatment (45-50°C) delivered through the vagina can calm overactive bladder symptoms. The heat targets nerve endings in the bladder muscle to reduce urgency and leakage. About 48 adults with moderate to severe symptoms will receive this office-b…

This study looks at whether transcutaneous electrical nerve stimulation (TENS), a treatment for overactive bladder, also affects the autonomic nervous system—the part of the body that controls heart rate and stress responses. Researchers will measure heart rate variability in adu…

This study looks at whether simple blood tests can predict how well women with overactive bladder respond to the drug mirabegron. Researchers will measure inflammation markers in the blood before treatment and see if they relate to symptom improvement after three months. The goal…

This study examines the most common symptoms of genitourinary syndrome of menopause (GSM) in postmenopausal women and how these symptoms impact quality of life. Researchers will also look at whether using a non-hormonal topical gel called XCM INTIM for at least 8 weeks is linked …

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This study will test a mobile app version of a bladder diary in 40 Portuguese adults with overactive bladder or urinary incontinence. Participants will use the app for one month and then answer questions about how easy it was to use and whether they prefer it over paper diaries. …

This study aims to learn what it's truly like to live with overactive bladder (OAB) by asking 2000 adults in eight European countries about their daily activities, emotional health, social life, and work. Participants complete surveys about their symptoms and quality of life. The…

This study looks at whether three proteins in urine—RhoA, NGF, and BDNF—can help doctors diagnose and monitor overactive bladder in children aged 4 to 18 who also have low vitamin D. Researchers will measure these proteins before and after standard behavioral therapy (urotherapy)…

This study will translate and test a questionnaire called USIQ, which measures how severe urinary urgency is and how it affects daily life, for Turkish-speaking women with overactive bladder. Researchers will enroll 130 women and compare their answers on the USIQ with other stand…

This study looks at whether people with overactive bladder can be monitored at home after receiving botulinum toxin injections, instead of going to the hospital. About 112 participants will be randomly assigned to either home or hospital follow-up. The goal is to see if home moni…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will follow 200 women who are either taking GLP-1 weight loss drugs or undergoing bariatric surgery. Researchers want to see how these treatments change pelvic floor symptoms like incontinence and prolapse. Participants do not need to have any pelvic floor symptoms to …