Overactive bladder

This early-phase trial tests whether a robotic bladder transplant from a deceased donor is feasible and safe for people with severe bladder problems. Only 5 participants will be enrolled. The main goal is to see if the transplanted bladder gets good blood flow. If it works, it mi…

This study tests a liquid medicine called mirabegron in children aged 6 months to 3 years who have bladder problems due to nerve damage (neurogenic detrusor overactivity). The goal is to see if the medicine helps the bladder hold more urine safely, reducing leaks and pressure. Ch…

This study is testing a new, recharge-free nerve stimulator (Axonics SNM system) in 144 adults with overactive bladder or fecal incontinence. The device is implanted to stimulate sacral nerves and improve control. Researchers will measure quality of life and symptom changes over …

This study looked at 70 men with an enlarged prostate and overactive bladder symptoms. Some received a Botox injection into the prostate during surgery, while others took standard medication after surgery. The Botox group showed better symptom scores at 12 weeks, suggesting a pot…

This study tests a small implant called INTIBIA that stimulates a nerve in the leg to help control sudden, strong urges to urinate. About 208 adults with overactive bladder and frequent leaking episodes will receive the implant. The goal is to see if it safely reduces leaking by …

This study planned to see if adding the daily pill vibegron to standard Botox bladder injections helps women with overactive bladder that hasn't improved with other treatments. Researchers aimed to compare changes in urgent leaks and symptom distress over 12 weeks. However, the t…

This study compares two treatments for women with urgency urinary incontinence (sudden, strong urges to urinate that lead to leakage). Participants will be randomly assigned to take an oral beta-agonist pill or receive Botox injections into the bladder. The main goals are to see …

This study tests the Revi System, a device that may help people with sudden, strong urges to urinate that cause leaking. About 150 adults who have had this problem for at least 6 months will either get the active device or an inactive version. The goal is to see if the active dev…

This study compares two ways of doing pelvic floor muscle training for postmenopausal women with urinary incontinence: one group does the exercises online with a physiotherapist, and the other does them in person. Both groups follow the same exercise plan. The goal is to see if t…

This study looks at whether adding a brief sleep program to standard bladder medication can reduce urgent leaks and nighttime urination in women aged 60 and older. About 120 women with frequent urgency incontinence and nocturia will receive either medication alone or medication p…

This study follows 200 adults with stress or urge incontinence to see how well two surgical procedures work over two years. One surgery tightens ligaments for stress incontinence, the other for urge incontinence. Researchers will measure success by continence rates and track any …

This study tests whether a device that sends mild electrical pulses to a nerve in the ankle (transcutaneous tibial nerve stimulation) can reduce overactive bladder symptoms and improve quality of life in women. Twenty-six women with idiopathic overactive bladder will receive the …

This study tests a non-invasive treatment called transcutaneous tibial nerve stimulation for women with overactive bladder who cannot or will not take medication. Thirty women will receive either real or sham stimulation twice a week for six weeks. Researchers will measure change…

This study tests whether a wearable device, used at home alongside pelvic floor therapy, can help people with multiple sclerosis manage bladder problems. Twenty women with MS will use the device for three months. The main goal is to see if the approach is practical and easy to us…

This study tests a program of balance and strength exercises, bladder training, and home safety checks in 375 women aged 70 and older who have urinary incontinence. The goal is to see if this approach reduces falls and improves bladder control compared to just giving them informa…

This study looks at whether a lower dose of Botox injected into the bladder can effectively treat urgent, frequent bladder leaks in women aged 70 and older. The goal is to reduce symptoms and improve quality of life while possibly causing fewer side effects than the standard dose…

This study tests whether a simple behavioral program—like timed bathroom visits and avoiding bladder irritants—works as well as supervised pelvic floor muscle training when both are combined with standard medication for urgency urinary incontinence. Eighty women with this conditi…

This study aimed to see if giving Botox injections into the bladder at the same time as HoLEP prostate surgery could improve urinary symptoms in men with an enlarged prostate and overactive bladder. The plan was to compare symptom scores and urine flow between men who got both tr…

This study is testing a new wireless device called the Glean Urodynamics System (GUS) that monitors bladder pressure without a catheter. It involves 28 adult women with urinary symptoms. Participants will use the device during standard tests and at home. The goal is to see if GUS…

This study aims to find the smallest change in symptom scores that actually matters to patients with overactive bladder. Researchers will treat 104 women with behavioral therapy and nerve stimulation, then analyze questionnaire results. The goal is to help doctors better interpre…

This study tests whether a program that trains primary care doctors can improve how they treat women with urinary incontinence. The program includes lectures, checklists, and tools to help doctors provide better care. Researchers will compare clinics that get the training to thos…

This study aims to better understand different types of urinary urgency (a sudden, strong need to urinate) in 840 adults. Researchers will look at symptoms, experiences, and other health factors to find patterns. The goal is to lay the groundwork for more personalized and effecti…

This study tests a guideline designed to help doctors safely reduce or stop overactive bladder medications in people aged 65 and older. Researchers will compare how many patients continue these drugs after six months between those whose doctors follow the guideline and those who …

This study from the Cleveland Clinic is looking at whether certain migraine medications (CGRP inhibitors) can also improve bladder symptoms like urgency, frequency, and pain. About 200 women with hard-to-treat migraines and bladder issues will be followed for 3 months. Their symp…