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Botox vs. blood plasma: which works better for a bladder that Won't quit?

NCT ID NCT07693192

Disease control Sponsor: Mahmoud Mohamed Farag Ali Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study compares two treatments for adults with overactive bladder that hasn't improved with standard medications. One group receives a single injection of Botox into the bladder, while the other gets three weekly instillations of Platelet-Rich Plasma (PRP) made from their own blood. Researchers track symptom changes, quality of life, and side effects over two years to see if PRP can match Botox's effectiveness with fewer risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Botulinum Toxin A (Botox) and Platelet-Rich Plasma (PRP)
What this could lead to
If PRP works as well as Botox but with fewer side effects, it could offer a safer, longer-lasting option for people with stubborn overactive bladder.
What could go wrong
This is a small, early-stage comparison. PRP is less studied for this condition, and results may not apply to everyone. Both treatments carry risks like infection or incomplete symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jun 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged ≥18 years * Diagnosis of refractory overactive bladder (OAB) * Failed at least 2 pharmacological therapies * Willing and able to provide informed consent Exclusion Criteria: * Neurogenic bladder * Active urinary tract infection (UTI) * Pregnancy or lactation * Known allergy to botulinum toxin or any PRP components * History of pelvic radiation or bladder malignancy * Uncontrolled coagulopathy or bleeding disorder

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Conditions

The condition(s) this trial relates to.

overactive bladder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overactive bladder

Contacts and locations

Locations

  • Benha University Hospital

    Banhā, Al Qalyubia, 13511, Egypt

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