OVERACTIVE BLADDER

This study tests whether adding high-dose vitamin D to standard care helps children with overactive bladder (wet) reach their goal of zero leakage. About 180 children aged 5 and older with low vitamin D levels will receive either standard treatment alone or standard treatment plu…

This study looks at how two different types of bladder medication affect thinking skills in women aged 60 and older who have sudden, strong urges to urinate. Participants will be randomly assigned to take one of two drugs or a placebo for 6 months. The goal is to see which option…

This study is testing a small device called eCoin that is implanted under the skin to stimulate a nerve in the leg. The goal is to reduce sudden, strong urges to urinate that lead to leaks. Researchers will track 200 adults with overactive bladder to see if the device safely cuts…

This study tests a new ultrasound method to measure bladder function without invasive procedures. Researchers at Mayo Clinic will compare the new technique to standard tests in adults with bladder issues or enlarged prostate. The goal is to see if this painless approach can accur…

This study tests a device called the Axonics SNM System, which uses mild electrical pulses to calm the nerves that control the bladder. It is for men with overactive bladder, including those with urgency incontinence or frequent urination. The trial will enroll 150 men and track …

This study tests whether injecting Botox into the bladder wall during a standard prostate surgery (HoLEP) can better control overactive bladder symptoms like sudden urges to urinate and leakage. About 66 men aged 18-89 with these symptoms will be randomly assigned to get Botox or…

This study tests a special sock called the ZIDA Control Sock that gives mild electrical pulses near the ankle to help people with overactive bladder who still have leaks despite taking medicine. About 20 adults will use the sock at home once a week for 12 weeks while staying on t…

This study tests a non-invasive brain stimulation technique called rTMS to improve bladder symptoms in women with multiple sclerosis. Participants receive either real or sham treatment over 10 sessions. The goal is to see if targeting specific brain areas can reduce urinary urgen…

This study compares two X-ray settings during a procedure to treat overactive bladder. The goal is to see if a new setting reduces radiation exposure while still placing the device correctly. About 44 adults with overactive bladder will take part. The results could make this comm…

This study looks at whether a 3-day trial of a nerve-stimulating device for bladder control works as well as the standard 7-day trial. About 193 women with urgent or frequent urination will be randomly assigned to either a 3-day or 7-day test. The goal is to see if the shorter tr…

This study looks at whether yoga can improve overactive bladder symptoms in children aged 8 to 18. Participants attend a weekly yoga session for 6 weeks. Researchers will track symptom changes using questionnaires and urine tests. The goal is to find a gentle, non-drug option for…

This study tests a device that uses radiofrequency energy inside the vagina to treat overactive bladder in women. It includes 202 women aged 22 to 80 who have had symptoms for at least 6 months. Half will get the real treatment and half a sham (fake) treatment to see if the devic…

This study looks at whether women with overactive bladder can remove a temporary nerve testing lead at home instead of coming back to the doctor's office. The lead is placed during a short procedure to see if a permanent nerve stimulator might help. Researchers want to know if wo…

This study tests whether a chair that uses electromagnetic pulses to strengthen pelvic floor muscles can help people with overactive bladder. About 166 adults who have not gotten relief from lifestyle changes or medications will sit in the chair twice a week for four weeks. Half …

This study tests whether women living in rural areas can use a simple TENS device at home to reduce overactive bladder symptoms. Thirty-eight women will apply mild electrical stimulation to a nerve in their ankle for 30 minutes, three times a week for 12 weeks. Researchers will t…

This study is testing a new device called Tensi+ that uses mild electrical pulses to help people with overactive bladder. Researchers will track 500 adults for one year to see if the device improves symptoms like sudden urges to urinate. The goal is to learn how well it works and…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…

This study looks at the bacteria found in urine, the genital area, and stool of children with overactive bladder and daytime wetting, comparing them to healthy children. Researchers want to see if these bacteria differ between the groups and if they change with treatment or as ki…

This study looks at how bladder sensations during filling are linked to overactive bladder severity in people with multiple sclerosis. Researchers will perform repeated cystometries, including a test with a distracting task, to assess sensation reliability. The goal is to better …

This study aims to collect electrical signals from the body in people with overactive bladder, fecal incontinence, or urinary retention who are receiving sacral neuromodulation therapy. Researchers will gather data at several time points during the evaluation period to better und…

This study aims to understand how electrical stimulation of the sacral nerve helps people with overactive bladder. Researchers will test two different ways to set the stimulation and see which one works better. Fifteen adults who already qualify for a sacral nerve implant will pa…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…