Overactive bladder

This study looked at children aged 3 to 15 with overactive bladder caused by nerve problems. It compared two different doses of Botox injections into the bladder muscle to see if a lower dose works just as well as a higher dose. The goal was to improve bladder capacity and reduce…

This study tested a small implantable device that stimulates the tibial nerve to treat overactive bladder. 188 adults with urge incontinence who had not improved with other treatments received the implant. The main goal was to see if at least half of participants had a 50% or gre…

This study tested a device that uses mild electrical pulses to calm the nerves controlling the bladder. It was for people with sudden, strong urges to urinate that cause leaks, who didn't get help from other treatments. The goal was to see if the device safely reduces leaks by at…

This completed study looked at how well the Axonics sacral neuromodulation system works for people with bladder or bowel control problems. 272 participants were tracked to see if their symptoms improved and if the device was safe. The device uses mild electrical pulses to calm ov…

This study tested a special chair that uses high-intensity electromagnetic waves to make pelvic floor muscles contract very strongly, like doing thousands of Kegel exercises in one session. 36 women with stress or urge urinary incontinence received either the full treatment or a …

This study looked at whether an automated measuring device can improve the accuracy of bladder diaries in women with lower urinary tract symptoms. 187 women recorded their urine volume using both a traditional paper diary and an electronic device. The goal was to see if the devic…

This study tested a new wireless device called the Glean Urodynamics System (GUS) that measures bladder pressure without a catheter. Thirty-eight adults with urinary symptoms used the device after a standard test. The goal was to see if the device is safe, easy to use, and more c…

This study tested whether pelvic floor muscle training, mirabegron, or trospium chloride is better for treating urgency urinary incontinence in women aged 60 and older who are also at high risk of falling. 48 women were randomly assigned to one of three groups and followed for si…

This study tests whether a daily cranberry extract pill can change the bacteria in the bladder to reduce sudden urges and frequent bathroom trips in women who do not have leakage. Researchers will compare bacteria samples and symptom scores before and after 12 weeks of treatment.…

This study tested a prescription smartphone app called RiSolve for women with overactive bladder (OAB). The app provides an 8-week program of bladder training, pelvic floor exercises, and digital cognitive behavioral therapy. Researchers enrolled 46 women in Ireland to see if the…

This study tested a smartphone app designed to help women with urinary incontinence reduce leakage episodes and improve quality of life. About 194 women used the app or received standard care for 12 weeks. The goal was to see if the app could cut incontinence episodes in half.

This study looked at whether two drugs, mirabegron and montelukast, are safe and helpful for people with liver cirrhosis who also have overactive bladder and asthma. 78 participants took part over 3 months. Researchers tracked bladder symptoms, breathing issues, and side effects …

This study tested whether a non-invasive magnetic brain stimulation technique (rTMS) can help adults with overactive bladder. Researchers measured changes in brain activity and bladder symptoms in 14 participants. The goal was to see if targeting specific brain regions could impr…

This study tested whether giving low-dose nitrous oxide (laughing gas) during a urodynamic study (a test for urinary symptoms) changes key bladder measurements like capacity and pressure. 19 adults scheduled for the test took part. If the measurements stay the same, nitrous oxide…

This study tested whether an extended-release version of the diuretic torsemide works better than the standard immediate-release form for reducing overactive bladder symptoms in people with chronic heart failure. Twenty-four participants took each version for four weeks, tracking…

This study tested whether giving Botox in one injection site works as well as ten sites for women with overactive bladder or urge incontinence. 116 women were randomly assigned to receive 100 units of Botox in either one or ten spots in the bladder. Researchers measured symptom s…

This study tested whether applying gentle radiofrequency energy (like deep heat) to the bladder area can reduce symptoms of overactive bladder and sudden urine leakage. 95 women were randomly assigned to receive either real radiofrequency or a sham (placebo) treatment. Researcher…

This study looked at whether a low-dose vaginal estrogen tablet could improve overactive bladder symptoms in menopausal women by changing the bacteria in their urine. Thirty women used the tablet daily for two weeks, then twice a week for 12 weeks. Researchers measured changes in…

This study tested whether women with overactive bladder (OAB) could easily use the FemPulse System, a non-implanted vaginal electrical stimulation device. Eleven women with OAB symptoms used the device and completed a survey about its usability. The goal was simply to see if the …

This completed trial tested a new non-implanted device that uses mild electrical stimulation to help control overactive bladder in women. 21 women with the condition used the FemPulse System, and researchers tracked side effects, urinary frequency, urgency, and quality of life. T…

This study tested whether women with overactive bladder (OAB) can easily use the FemPulse system at home. Five women with OAB for over 6 months participated. The main goal was to see if they were satisfied with using the device as instructed.

This study tested two ways of scheduling maintenance therapy for overactive bladder using percutaneous tibial nerve stimulation (PTNS). 37 women who had already completed 12 weekly PTNS sessions were assigned to either monthly treatments or sessions only when they felt they neede…

This study looked at whether a home-based nerve stimulation treatment (TTNS) works as well as a clinic-based version (PTNS) for overactive bladder. About 70 patients from a county hospital tried one of the two treatments and reported their symptoms and satisfaction. The goal was …

This study looked at whether adding tadalafil (a drug for erectile dysfunction and enlarged prostate) to solifenacin (a standard overactive bladder drug) works better than solifenacin alone for women with overactive bladder. 80 women aged 18 to 60 with symptoms for over 6 months …

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested whether mild electrical pulses to nerves in the leg and lower back can help women with multiple sclerosis who have overactive bladder symptoms like sudden urges and leaks. Forty-two women received the stimulation over several sessions. The goal was to see if it …

This study tested whether high-dose vitamin D plus behavioral therapy can help children with dry overactive bladder (OAB) urinate less often. 180 children received either standard drugs or vitamin D drops for a short time. The goal was to see if vitamin D works better than usual …

This study tested whether stimulating nerves on one side or both sides of the body works better for people with overactive bladder that hasn't improved with standard treatments. 55 adults were randomly assigned to receive either unilateral or bilateral nerve stimulation. The goal…

This study tested a small device called eCoin that is implanted under the skin near the ankle to stimulate a nerve that controls the bladder. The goal was to see if it could reduce urgent, frequent urination and accidental leaks in people with overactive bladder. 133 adults who h…

This study tested a small implantable device that stimulates a nerve in the leg to help control overactive bladder symptoms. 282 women with frequent sudden urine leaks received the implant. The main goal was to see if at least half of them had a 50% or greater reduction in leaks …

This study tested whether a magnetic stimulation chair can help women with sudden, strong urges to urinate that lead to leaks. 70 women received either real or sham magnetic stimulation while sitting fully clothed. Researchers measured changes in bladder diary entries, questionna…

This completed study looked at how the brain controls the bladder in older women with urgency urinary incontinence. Researchers used MRI scans to compare brain activity during bladder filling and emptying in 207 women, both young and old, with and without incontinence. The goal w…

This study looked at how the brain works in women aged 60 and older who have sudden, strong urges to urinate (urgency urinary incontinence). Participants took a medication called trospium or a placebo, and had brain scans (MRI) to see if changes in brain activity relate to fewer …

This study looked at 61 women with overactive bladder whose symptoms didn't improve with one medication. Researchers gave them a combination of two drugs and tracked which factors made treatment more likely to fail. The goal was to better understand who might need different treat…