Could one botox shot replace ten for bladder control?

NCT ID NCT05308979

Completed Symptom relief Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving Botox in one injection site works as well as ten sites for women with overactive bladder or urge incontinence. 116 women were randomly assigned to receive 100 units of Botox in either one or ten spots in the bladder. Researchers measured symptom severity and quality of life using questionnaires before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Botox (onabotulinumtoxinA)
What this could lead to: If successful, this could show that a single injection works as well as ten, making the procedure simpler and less uncomfortable.
What could go wrong: This is a small, completed Phase 4 trial with only 116 women. Results may not apply to men or people with other bladder conditions. Botox can cause temporary urinary retention or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

overactive bladder Urinary Incontinence, Urge

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVERACTIVE BLADDER OVERACTIVE BLADDER SYNDROME URGE INCONTINENCE URINARY FREQUENCY URINARY INCONTINENCE, URGE URINARY URGE INCONTINENCE URINARY URGENCY

Contacts and locations

Locations

University of California Irvine Medical Center

Orange, California, 92868, United States

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