New implant zaps nerves to stop bladder leaks

NCT ID NCT05226286

Completed Disease control Sponsor: MedtronicNeuro Source: ClinicalTrials.gov ↗

First seen Nov 21, 2025 · Last updated Jun 19, 2026 · Updated 32 times

Summary

This study tested a small implantable device that stimulates the tibial nerve to treat overactive bladder. 188 adults with urge incontinence who had not improved with other treatments received the implant. The main goal was to see if at least half of participants had a 50% or greater reduction in daily leakage episodes after 6 months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alliance Urology Specialists

Greensboro, North Carolina, 27403, United States
Ascension Columbia St. Mary's

Milwaukee, Wisconsin, 53211, United States
Associated Medical Professionals

Syracuse, New York, 13210, United States
Atrium Health Carolinas Medical Center

Charlotte, North Carolina, 28203, United States
Central Ohio Urology Group

Gahanna, Ohio, 43230, United States
Chesapeake Urology Associates

Towson, Maryland, 21204, United States
FirstHealth Urogynecology

Hamlet, North Carolina, 28345, United States
Georgia Urology

Cartersville, Georgia, 30120, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Louisiana State University Health Sciences Center

New Orleans, Louisiana, 70006, United States
Mayo Clinic Urology

Rochester, Minnesota, 55905, United States
Mercy Health Saint Mary's

Grand Rapids, Michigan, 49503, United States
Michigan Institute of Urology

Troy, Michigan, 48084, United States
Minnesota Urology

Plymouth, Minnesota, 55441, United States
Northwestern Medicine

Chicago, Illinois, 60611, United States
Prisma Health

Greenville, South Carolina, 29605, United States
Providea Health Partners

Evergreen Park, Illinois, 60805, United States
Sanford Female Pelvic Medicine & Reconstructive Surgery Clinic

Sioux Falls, South Dakota, 57105, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
Summit Health Englewood

Englewood, New Jersey, 07631, United States
Summit Health Voorhees

Voorhees Township, New Jersey, 08043, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Texas Medical Branch

Galveston, Texas, 77555, United States
Urology Centers of Alabama

Homewood, Alabama, 35209, United States
Urology Partners of North Texas Research Institute

Arlington, Texas, 46017, United States
Urology Surgeons of Oklahoma

Oklahoma City, Oklahoma, 73120, United States
Virginia Mason Medical Center

Seattle, Washington, 98101, United States
Wright State Physicians

Fairborn, Ohio, 45234, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Medtronic Implantable Tibial Neuromodulation (TNM) System

What this could lead to

If successful, this device could offer a long-term, implantable option for people with overactive bladder who haven't improved with other treatments.

What could go wrong

This is a completed pivotal study, but results may not apply to everyone. Risks include surgical implantation, device malfunction, or lack of symptom relief.

Conditions

The condition(s) this trial relates to.

overactive bladder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVERACTIVE BLADDER OVERACTIVE BLADDER