Can a depression drug ease bladder pain? new study investigates

NCT ID NCT00124306

Completed Symptom relief Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether amitriptyline, a drug already used for depression and some chronic pain conditions, can relieve symptoms of painful bladder syndrome (PBS) in people newly diagnosed with the condition. PBS causes frequent urination and increasing pain as the bladder fills, affecting millions, mostly women. The trial enrolled 271 participants and measured symptom improvement using a patient-reported global response assessment after 12 weeks.

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Conditions

The condition(s) this trial relates to.

interstitial cystitis urinary bladder disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER DISEASES INTERSTITIAL CYSTITIS

Contacts and locations

Locations

Henry Ford Hospital

Detroit, Michigan, 48202, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Queen's University

Kingston, Ontario, K7L 2Y7, Canada
Stanford University Medical Center

Stanford, California, 94305, United States
University of Iowa Hospitals and Clinic

Iowa City, Iowa, 52242, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Washington

Seattle, Washington, 98195, United States
William Beaumont Hospital

Royal Oak, Michigan, 48073, United States

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