Can a depression drug ease bladder pain? new study investigates
NCT ID NCT00124306
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether amitriptyline, a drug already used for depression and some chronic pain conditions, can relieve symptoms of painful bladder syndrome (PBS) in people newly diagnosed with the condition. PBS causes frequent urination and increasing pain as the bladder fills, affecting millions, mostly women. The trial enrolled 271 participants and measured symptom improvement using a patient-reported global response assessment after 12 weeks.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Queen's University
Kingston, Ontario, K7L 2Y7, Canada
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Stanford University Medical Center
Stanford, California, 94305, United States
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University of Iowa Hospitals and Clinic
Iowa City, Iowa, 52242, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Washington
Seattle, Washington, 98195, United States
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William Beaumont Hospital
Royal Oak, Michigan, 48073, United States