Weekly bladder radiation shows promise for patients unable to have standard treatment

NCT ID NCT01810757

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a weekly, higher-dose radiation schedule (hypofractionated radiotherapy) for people with muscle-invasive bladder cancer who cannot have standard daily radiation or surgery. It included 65 participants and compared standard radiation planning with a newer 'adaptive' technique that adjusts the radiation field each session based on the bladder's changing shape. The goal was to see if this approach is safe and effective at controlling the tumor while reducing side effects.

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Conditions

The condition(s) this trial relates to.

infiltrating bladder urothelial carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Addenbrooke's Hospital

    Cambridge, United Kingdom

  • Clatterbridge Cancer Centre

    Metropolitan Borough of Wirral, United Kingdom

  • Guy's & St Thomas's Hospital

    London, United Kingdom

  • Ipswich Hospital

    Ipswich, United Kingdom

  • Norfolk & Norwich University Hospitals NHS Foundation Trust

    Norwich, United Kingdom

  • Queens Hospital

    Romford, United Kingdom

  • Royal Marsden NHSFT

    London, United Kingdom

  • Royal Preston Hospital

    Preston, United Kingdom

  • St James's University Hospital

    Leeds, United Kingdom

  • University College London

    London, United Kingdom

  • Velindre Cancer Centre

    Cardiff, United Kingdom