Could an arthritis drug boost bladder cancer chemo?
NCT ID NCT02885974
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether adding the anti-inflammatory drug celecoxib (Celebrex) to standard chemotherapy before bladder cancer surgery is safe and affects tumor genes. 22 people with muscle-invasive bladder cancer took part. The goal was to see how the treatment changed cancer cells, not to cure the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
celecoxib (an anti-inflammatory drug) combined with gemcitabine and cisplatin (chemotherapy drugs)
What this could lead to
If successful, this could point toward a more effective pre-surgery treatment for muscle-invasive bladder cancer, potentially improving outcomes.
What could go wrong
This is a very early, small pilot study (22 people) focused on safety and gene expression, not on proving the treatment works. The added benefit of celecoxib is uncertain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor Clinic
Houston, Texas, 77030, United States
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Harris Health System - Smith Clinic
Houston, Texas, 77054, United States