Freeze and fight: new combo tackles metastatic bladder cancer
NCT ID NCT04701918
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 2 trial tested a combination of cryoablation (freezing tumors with a needle) and immunotherapy drugs (pembrolizumab or avelumab) in 9 people with metastatic bladder cancer. The goal was to see if this approach could shrink tumors that were not frozen. The study measured how well the treatment worked and tracked side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pembrolizumab (Keytruda) or avelumab (Bavencio) plus cryoablation
What this could lead to
If it works, this could point toward a new combination treatment that helps control metastatic bladder cancer by freezing tumors and boosting the immune system.
What could go wrong
This is a very small, early-phase trial with only 9 participants, so results may not apply to everyone. The combination may cause side effects or not improve outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States