Cure My Disease

Don't miss your cure!

 Log in / Sign up

Experimental cancer pill targets genetic weakness in Hard-to-Treat tumors

NCT ID NCT05512377

Terminated Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called brigimadlin (BI 907828) in 99 adults with advanced cancers of the bile duct, pancreas, lung, or bladder that have a specific genetic change (MDM2 amplification). Participants took the drug as a tablet once every 3 weeks. The goal was to see if the drug could shrink tumors. However, the study was terminated early, so results are not yet available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

brigimadlin (BI 907828), an MDM2 inhibitor taken as a tablet

What this could lead to

If it works, this could provide a new treatment option for people with certain advanced cancers that have a specific genetic change (MDM2 amplification).

What could go wrong

This is an early-phase (Phase II) trial that was terminated, so results are limited. The drug may not shrink tumors or improve survival, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BLADDER CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bile duct adenocarcinoma biliary tract cancer Biliary Tract Neoplasms bladder transitional cell carcinoma lung adenocarcinoma lung neoplasm pancreatic ductal adenocarcinoma pancreatic neoplasm urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT CANCER BLADDER CANCER LUNG NEOPLASMS PANCREATIC NEOPLASMS SOLID TUMORS

Contacts and locations

Locations

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Austin Health

    Heidelberg, Victoria, 3084, Australia

  • CTR Georges-François Leclerc

    Dijon, 21079, France

  • China Medical University Hospital

    Taichung, 404327, Taiwan

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Edegem - UNIV UZ Antwerpen

    Edegem, 2650, Belgium

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042, Australia

  • Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • ICON-South Brisbane-69267

    South Brisbane, Queensland, 4101, Australia

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Japanese Foundation for Cancer Research

    Tokyo, Koto-ku, 135-8550, Japan

  • Johns Hopkins Sidney Kimmel Cancer Center at Sibley Memorial Hospital

    Washington D.C., District of Columbia, 20016, United States

  • Kanagawa Cancer Center

    Kanagawa, Yokohama, 241-8515, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756, Taiwan

  • King Abdul Aziz Medical City

    Riyadh, 11481, Saudi Arabia

  • Klinikum der Universität München AÖR

    München, 81377, Germany

  • Krankenhaus Nordwest, Frankfurt

    Frankfurt, 60488, Germany

  • LK Wiener Neustadt

    Wiener Neustadt, 2700, Austria

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10022, United States

  • National Cancer Center Hospital

    Tokyo, Chuo-ku, 104-0045, Japan

  • National Cancer Center Hospital East

    Chiba, Kashiwa, 277-8577, Japan

  • National Taiwan University Cancer Center

    Taipei, 106, Taiwan

  • National University Hospital-Singapore-42005

    Singapore, 119074, Singapore

  • Nebraska Cancer Specialists-Omaha-69066

    Omaha, Nebraska, 68130, United States

  • Norton Cancer Institute, Downtown

    Louisville, Kentucky, 40202, United States

  • Oncology Associates of Oregon, PC

    Eugene, Oregon, 97401, United States

  • Ordensklinikum Linz GmbH - Barmherzige Schwestern

    Linz, 4020, Austria

  • Oregon Health and Sciences University

    Portland, Oregon, 97239, United States

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Perlmutter Cancer Center at NYU Langone Hospital - Long Island

    Mineola, New York, 11501, United States

  • Prince of Wales Hospital-Randwick-66496

    Randwick, New South Wales, 2031, Australia

  • Providence Medical Foundation-Santa Rosa -69764

    Santa Rosa, California, 95403, United States

  • Rainbow Oncology

    KwaZulu, 4126, South Africa

  • Rocky Mountain Cancer Centers-Lone Tree-69498

    Lone Tree, Colorado, 80124, United States

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital

    Seoul, 03722, South Korea

  • Songklanagarind Hospital

    Hat Yai, 90110, Thailand

  • Southern Cancer Center

    Mobile, Alabama, 36608, United States

  • Srinagarind Hospital

    Muang, 40002, Thailand

  • Stanford Cancer Institute

    Palo Alto, California, 94305, United States

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tohoku University Hospital

    Miyagi, Sendai, 980-8574, Japan

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • University College Hospital

    London, WC1E 6AG, United Kingdom

  • University Hospital Bern

    Bern, 3010, Switzerland

  • University Hospital Geneva

    Geneva, CH-1211, Switzerland

  • University of Arizona

    Tucson, Arizona, 85719, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Southern California

    Los Angeles, California, 90033-9173, United States

  • Universitätsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Yamaguchi University Hospital

    Yamaguchi, Ube, 755-8505, Japan