LUNG NEOPLASMS

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study tests a new medicine called PF-08634404, given alone or with chemotherapy, for adults with early or locally advanced non-small cell lung cancer. The trial has three parts: before surgery, after surgery if cancer remains, or after chemoradiation. Researchers will check …

This study tests a new medicine called PF-08634404 given with chemotherapy for adults with transformed small cell lung cancer (T-SCLC), a rare and aggressive cancer that develops from another lung cancer type. About 40 participants will receive the drug combo through IV infusions…

This study tests whether a team of specialists—including surgeons, oncologists, and geriatricians—can create better treatment plans for elderly lung cancer patients. 2,000 people aged 60-90 will receive personalized care based on their overall health and cancer type. The goal is …

This study tests a drug called teniposide in people with a fast-growing type of lung cancer (extensive-stage small cell lung cancer) that has a specific gene change (c-Myc-driven). The cancer must have gotten worse after standard treatments. The goal is to see if teniposide can s…

This study is testing whether a blood test (liquid biopsy) can be used as a first step to screen for lung cancer in high-risk people, before deciding if they need a low-dose CT scan. The goal is to reduce unnecessary scans, radiation exposure, and healthcare costs. The study will…

This study uses mobile low-dose CT scans to screen for lung cancer in people aged 40-54 who have a heavy smoking history (30 pack-years or more). Participants in North and South Carolina will get up to three scans over time. The goal is to see if screening younger high-risk smoke…

This study compares three robotic-assisted surgery methods for lung removal to see which causes the least chronic pain. 120 adults having lung surgery will be followed for 6 months. The goal is to find a technique that reduces nerve damage and long-term chest pain.

This phase 2 trial tests whether a dexamethasone mouthwash can lower the chance of painful mouth sores (stomatitis) caused by the cancer drug datopotamab deruxtecan. About 60 people with advanced breast or lung cancer will use the mouthwash for the first five days of each treatme…

This study will review health records of 60,000 adults with lung cancer in Alberta and Ontario to understand current treatments, survival rates, and healthcare costs. It aims to describe real-world patterns rather than test a new treatment. No direct benefit to participants, but …

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors will use 3D CT scans to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to see if this method is more accurate than current techniques, hel…

This study looks at the real-world treatment of advanced non-small cell lung cancer (NSCLC) in Brazil. Researchers will review medical records of 200 patients and survey doctors to see if treatments follow national guidelines. The goal is to understand patient demographics and im…

This study looks at whether advanced blood tests and artificial intelligence can help detect lung cancer recurrence earlier and without invasive procedures. About 100 adults who had surgery for stage IB-IIIA lung cancer and received standard chemo-immunotherapy before surgery wil…

This study looks at tumor samples from 500 adults with lung or other chest cancers to find out why some treatments stop working. Researchers will study genetic changes in the cancer cells. The goal is to learn how to better choose the next treatment for each person.

This study collects blood and tissue samples from 2,000 people being tested or treated for lung cancer. The samples are stored for future research into earlier detection, better treatments, and prevention strategies. No direct benefit is offered to participants, but the bank coul…

This study tests whether a remote decision coaching program helps people at high risk for lung cancer make better-informed choices about screening. About 594 participants aged 50-77 who smoke or recently quit will receive either coaching or usual care. The goal is to see if coach…

This study tests a telehealth coaching program called TELESCOPE, designed to help Hispanic adults at high risk for lung cancer decide whether to get screened. The program includes a decision aid, smoking cessation support, and help navigating the screening process. Researchers wi…

This study is a registry that will collect information from about 3,750 adults with lung cancer across 21 hospitals in Algeria. Researchers will track patients' health, treatments, and outcomes during routine care. The goal is to better understand lung cancer in Algeria and help …