LUNG NEOPLASMS

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment involves collecting a patient's own immune cells, modifying them in a lab to better re…

This study tests a drug called teniposide in 15 people with advanced small cell lung cancer that has a specific gene change (c-Myc) and has stopped responding to standard treatments. The goal is to see if the drug can shrink tumors and control the disease. Participants must be in…

This study tests a new medicine (PF-08634404) given with chemotherapy, then alone, for adults with transformed small cell lung cancer (T-SCLC), a rare and aggressive cancer. About 40 participants who have not yet been treated for T-SCLC will receive the drugs through IV infusions…

This study is testing whether a blood test can be used as a first step to see who really needs a low-dose CT scan for lung cancer. The goal is to avoid unnecessary scans, radiation, and costs for people at high risk, including smokers and those with a family history of lung cance…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more). The goal is to catch lung cancer earlier than current guidelines allow, potentially saving more lives. Participants will be screened up to three times over a few …

This study aims to see how well a robotic system works for finding and taking samples from suspicious spots in the lungs. It will observe 3,000 adults who are already scheduled to have this procedure as part of their regular care. The main goal is to measure how often the biopsy …

This study tests whether a dexamethasone mouthwash can reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 60 adults with advanced HER2-negative breast cancer or non-small cell lung cancer will use the mouthwash four times a day for the first fiv…

This study tests whether a health coach can help people aged 50-77 who smoke or used to smoke make better decisions about lung cancer screening. About 594 participants will either get a coaching session or usual care. The goal is to see if coaching leads to more informed choices …

This study looks at tumor samples from 500 adults with lung or chest cancers to find genetic changes that make targeted therapies stop working. Participants provide tissue from routine biopsies or procedures. The goal is to learn how cancers become resistant, not to test a new tr…

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors use a 3D CT scan to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to improve safety and help plan recovery. About 60 adults with non-smal…

This study looks at the real-world treatment of advanced non-small cell lung cancer in Brazil. Researchers will review medical records of 200 patients and survey doctors to see if treatments follow national guidelines. The goal is to understand patient characteristics and improve…

This study collects tissue and blood samples from 2,000 people being tested or treated for lung cancer. The samples are stored in a bank for future research, with the goal of helping scientists find better ways to detect, treat, and prevent lung cancer. Participants give consent …

This study is testing whether a team of different specialists (like surgeons, cancer doctors, and geriatricians) can create better, personalized treatment plans for older adults (ages 60-90) with lung cancer. The goal is to see if this team approach helps people live longer witho…

This study will review health records of 60,000 people with lung cancer in Alberta and Ontario to understand how the disease is treated, what outcomes patients have, and how much care costs. It aims to provide a clear picture of current treatment patterns and healthcare resource …

This study tests a culturally tailored coaching program to help Hispanic smokers and former smokers decide whether to get screened for lung cancer. About 91 participants will work with bilingual patient navigators who guide them through the decision process. The goal is to see if…

This study is collecting information from 3,750 adults with lung cancer across 21 hospitals in Algeria. Researchers will look at patient backgrounds, tumor types, treatments, and outcomes to understand how lung cancer is managed in real-world settings. No new treatments are teste…

This study looks at whether advanced blood tests and artificial intelligence can detect lung cancer coming back after surgery, earlier than standard scans. Researchers will follow 100 people who had lung cancer surgery and chemotherapy. The goal is to create a better monitoring s…