Mouthwash may tame cancer Drug's side effect in breast and lung cancer

NCT ID NCT06974604

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 31 times

Summary

This study tests whether a dexamethasone mouthwash can reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 60 adults with advanced HER2-negative breast cancer or non-small cell lung cancer will use the mouthwash four times a day for the first five days of each three-week treatment cycle. The goal is to lower the rate of stomatitis (mouth inflammation) by 20% compared to historical data.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Rhode Island and the Miriam Hospitals (Brown University Health)

    RECRUITING

    Providence, Rhode Island, 02903/02906, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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