Brown University

This study is testing whether doxazosin, a medication typically used for high blood pressure, can help people with alcohol use disorder drink less and have fewer cravings. Researchers will compare the medication against a placebo in 184 adults who want to reduce their alcohol use…

This study is testing whether a single dose of insulin, delivered as a nasal spray, can help people with alcohol use disorder manage their cravings and drinking. Researchers will give the spray or a placebo to 40 participants in a controlled bar lab setting to see if it safely af…

This study is testing a new support program to help young LGBTQ+ people living with HIV in Brazil take their daily medication more consistently. The program combines group counseling sessions with daily text message reminders. Researchers want to see if this approach helps partic…

This study is testing whether combining two drugs—mosunetuzumab and lenalidomide—works better than current treatments for people newly diagnosed with certain slow-growing lymphomas. The trial will enroll 52 adults who haven't had any previous cancer treatment. Doctors will adjust…

This study is testing a program called STEP to see if it can reduce suicide attempts and suicidal thoughts in teenagers who have been hospitalized for suicide risk. 216 teens will be randomly assigned to either the STEP program or to receive standard care plus reminders to use a …

This study is testing a new, less intense treatment plan for frail seniors aged 65+ with head and neck cancer. The goal is to see if a tailored combination of chemotherapy and/or immunotherapy, followed by radiation, can effectively control the cancer while being easier for older…

This study is testing if a medication called probenecid can help people with alcohol use disorder. Over 16 weeks, 120 participants will take either probenecid or a placebo pill to see if it reduces their cravings for alcohol and how much they drink. The main goal is to see if thi…

This study is testing a new pre-surgery treatment for people with operable non-small cell lung cancer. Before having surgery to remove the tumor, participants receive a combination of two immunotherapy drugs (ipilimumab and nivolumab) along with a short, targeted course of low-do…

This study is testing a new digital platform designed to help prevent suicide among teenagers in Colombia. The program includes a mobile app with self-help tools and safety planning for students, plus a training course for teachers to help them spot warning signs. Researchers wil…

This study is testing if a steroid mouthwash can prevent painful mouth sores, a common side effect of a cancer drug called datopotamab deruxtecan. It will enroll 60 adults with advanced breast or lung cancer who are receiving this drug. The main goal is to see if using the mouthw…

This study aims to understand how daily pain, mood, and activities are connected by having 800 participants use a smartphone app called SOMA for four months. The goal is to find patterns that might predict when short-term (acute) pain becomes long-term (chronic) pain. A smaller g…

This study aims to understand why young adults use both marijuana and tobacco together. Researchers will observe 120 participants, aged 18-25, who currently use both substances. The study involves lab sessions where researchers will measure how changes in price and exposure to cu…

This study aims to understand how sleep helps our brains learn visual patterns. Researchers will scan the brains of 10 healthy volunteers while they nap, measuring brain activity before and after visual training. The goal is to see if specific brain patterns during sleep are link…

This study aims to understand how repeatedly recalling memories changes the way the brain's visual areas represent those memories. Researchers will use brain scans (fMRI) on 30 healthy adults while they remember simple patterns and complex images multiple times. The goal is to se…

This study aims to understand how the brain learns to see better through practice, a process called perceptual learning. Researchers will train participants on visual tasks and measure changes in their performance and brain activity. The goal is to gather knowledge that could one…