Brown University

This study tests a smartphone app designed to help young adults aged 18 to 25 who want to reduce their combined use of alcohol and opioids. The app sends timely tips based on users' daily reports. The goal is to see if the app is usable, satisfying, and worth testing in larger st…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This phase 2 trial is testing whether giving low-dose radiation along with two immunotherapy drugs (ipilimumab and nivolumab) before surgery can shrink tumors in people with stage IB to III non-small cell lung cancer. About 25 participants will receive the combination, then have …

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …

This Phase 2 trial tests whether probenecid, a drug currently used for gout, can reduce alcohol cravings and drinking in people with alcohol use disorder. Over 16 weeks, 120 participants will receive either probenecid or a placebo, and researchers will measure changes in craving …

This study tests a milder combination of chemotherapy, immunotherapy, and radiation for adults aged 65 and older with head and neck cancer who are considered frail. The goal is to see if more patients can complete the full treatment course. The regimen is tailored based on a biom…

This phase 2 study is testing two drugs, mosunetuzumab and lenalidomide, as the first treatment for people with follicular or marginal zone lymphoma. Participants start with mosunetuzumab alone, and those who only partially respond get lenalidomide added. The goal is to see how m…

This study is testing a group-based support program to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro take their HIV medication consistently. The program includes four sessions that focus on building social support, self-confidence, and problem-solvin…

This early-stage trial tests whether a single dose of insulin given as a nasal spray can reduce alcohol cravings and consumption in people with alcohol use disorder. Forty non-treatment-seeking volunteers will receive either insulin or a placebo and then be exposed to alcohol-rel…

This phase 2 trial tests whether a dexamethasone mouthwash can lower the chance of painful mouth sores (stomatitis) caused by the cancer drug datopotamab deruxtecan. About 60 people with advanced breast or lung cancer will use the mouthwash for the first five days of each treatme…

This study is testing a program called STEP that teaches teens skills like mindfulness, gratitude, and savoring positive moments. The goal is to see if it can reduce suicidal thoughts and attempts after a teen is discharged from inpatient psychiatric care. 216 teens will be rando…

This study investigates how sleep improves visual learning by scanning the brains of 10 healthy volunteers aged 18-30. Participants will undergo visual training and then have their brain activity measured with MRI and sleep monitors. The goal is to understand what happens in the …

This study is testing a digital platform and teacher training program to reduce suicidal thoughts and behaviors among Colombian youth aged 14-19. About 228 teens from three schools in Bogota will use the platform, which includes self-help tools, safety planning, and links to coun…

This study looks at how young adults (ages 18-25) who smoke both marijuana and tobacco decide to use each substance when prices change. Researchers will measure cravings after showing pictures of marijuana or tobacco. The goal is to understand patterns of dual use, not to test a …

This study looks at how recalling memories over and over changes the way the brain processes visual information. Healthy adults will have their brains scanned with fMRI while they remember pictures and patterns. The goal is to understand whether repeated recall strengthens or alt…

This study aims to understand how our vision improves with practice, a process called perceptual learning. Researchers will measure changes in how well people detect or tell apart visual patterns after training, and link those changes to brain activity. The study needs 400 health…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…