Brown University

This study is testing a program that combines counseling and technology to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro, Brazil, take their HIV medication consistently. The goal is to improve social support, confidence, and problem-solving skills to…

This study tests whether probenecid, a medicine currently used for gout, can help people with alcohol use disorder drink less and feel less craving. About 120 adults who drink heavily will take either probenecid or a placebo daily for 16 weeks. Researchers will measure cravings i…

This study is for people with stage IB to III non-small cell lung cancer that can be removed with surgery. Before surgery, participants receive a low dose of targeted radiation along with two immunotherapy drugs (ipilimumab and nivolumab). The goal is to see if this combination c…

This study tests a two-drug combination (mosunetuzumab and lenalidomide) as the first treatment for adults with follicular or marginal zone lymphoma. Participants receive the drugs in cycles, with adjustments based on how well the cancer responds. The goal is to see how many peop…

This study tests whether a medication that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. Researchers want to understand how stress plays a role in drinking. About 184 adults who want to cut back or quit drinking will take the…

This study tests a less intense treatment for older adults (65+) with head and neck cancer who are considered frail. Participants receive a personalized mix of chemotherapy and immunotherapy based on their tumor's markers, followed by radiation. The goal is to see if more patient…

This study tests whether a dexamethasone mouthwash can reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 60 adults with advanced HER2-negative breast cancer or non-small cell lung cancer will use the mouthwash four times a day for the first fiv…

This study tests whether a single dose of insulin given as a nasal spray can reduce cravings and the effects of alcohol in people with alcohol use disorder. Forty non-treatment-seeking adults will receive either insulin or a placebo and then be exposed to alcohol-related cues and…

This study tests a program called STEP that teaches teens skills like mindfulness, gratitude, and savoring positive moments to reduce suicidal thoughts and events. About 216 teens hospitalized for suicide risk will either get STEP or standard care. The goal is to see if these ski…

This study tests a mindfulness program delivered through a smartphone app for young adults aged 18-24 who have experienced early life adversity. Participants will use the app, attend weekly Zoom group sessions, and wear a Fitbit to track sleep. The goal is to see if the program i…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study aims to understand how young adults (ages 18-25) who use both marijuana and tobacco make choices based on price and availability. Researchers will measure cravings after showing participants cues related to each substance. The goal is to gather information, not to test…

This study aims to understand how practicing visual tasks can improve performance, a process called perceptual learning. Researchers will measure changes in how well people detect or identify visual patterns after training, and also look at brain signals using neuroimaging. The s…

This study looks at how sleep improves visual learning. Researchers will use MRI and sleep monitoring to see what happens in the brain during sleep. Ten healthy adults aged 18-30 will take part. The goal is to understand the process, not to test a treatment.

This study will test a digital platform and teacher training program to reduce suicidal thoughts and improve mental health in 228 Colombian youth aged 14-19. The platform offers self-help tools, safety planning, and counseling links, while teachers get training to spot warning si…

This study looks at how recalling a memory over and over changes the way the brain processes visual information. Healthy adults aged 18-40 will have their brains scanned with fMRI while they remember pictures and patterns. The goal is to understand whether repeated recall strengt…