Brown University

This study tests whether a smartphone app that connects people recovering from opioid use disorder with peer support can help them stay in treatment and improve their recovery. About 1,300 adults who own a smartphone and are in recovery or treatment for opioid use will use the ap…

This study tests whether a combination of two immunotherapy drugs, nivolumab and low-dose ipilimumab, can prevent melanoma from returning in people who have had surgery to remove stage III or IV melanoma. The treatment is given every few weeks for six months. The main goals are t…

This study tests whether extra support after a hospital stay can help prevent suicide in high-risk veterans. 850 veterans will either get standard care or standard care plus a program called CLASP, which provides ongoing coping and support for 6 months. Researchers will track sui…

This study tests whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) works better than nivolumab alone for people with advanced clear cell ovarian, fallopian tube, or peritoneal cancer. About 46 participants will receive either one or both drugs to see if …

This study looks at whether a 1-year treatment with two drugs (Enhertu and nivolumab) can safely prevent cancer from returning in people with HER2-positive esophageal or stomach-junction cancer. Participants have already completed standard therapy (chemoradiation and surgery) but…

This study was designed to test a device (NovoTTF-200A) combined with the immunotherapy drug pembrolizumab in people with melanoma that had spread to the brain. The goal was to see if the combination was safe and effective. However, the study was withdrawn before enrolling any pa…

This study tests a program called Safe South Africa, designed to help teenage boys aged 15-17 reduce their risk of HIV and stop intimate partner violence. The program is being tested with 836 boys in South African high schools. Researchers will check if the program lowers new HIV…

This study explores whether creating a personalized music playlist can help people cope with the loss of a spouse or life partner. Thirty adults from a grief support group will work with a researcher to build a playlist based on their feelings and memories. Surveys before and aft…

This study tests a brief, acceptance-based behavioral therapy to improve mental health in 240 LGBTQ+ adults who have mild anxiety or depression. Participants either receive the therapy or continue their usual care. The goal is to see if this short intervention can reduce symptoms…

This study tests whether machine learning can predict which HIV patients are likely to miss clinic visits or have treatment failure. Researchers will develop risk prediction tools and provide them to clinic staff in Kenya. They will compare outcomes between clinics using the tool…