Brown University

This study is for people with HER2-positive esophageal or gastroesophageal junction cancer who have already completed chemoradiation and surgery. The goal is to see if adding a year of treatment with trastuzumab deruxtecan (Enhertu) plus nivolumab is safe and helps prevent the ca…

This phase II trial tests a combination of two immunotherapy drugs, nivolumab and low-dose ipilimumab, given after surgery to patients with stage III or resected stage IV melanoma. The goal is to see if this regimen is safer and more effective than standard high-dose interferon, …

This study tests whether a combination of two immune-boosting drugs (nivolumab and ipilimumab) works better than nivolumab alone for people with advanced clear cell cancers of the ovary, fallopian tube, peritoneum, or other areas. About 46 participants will receive one of the two…

This study tests whether a smartphone app that connects people in recovery from opioid use disorder with peer supporters can help them stay on track. About 1,300 adults who own a smartphone and are in recovery or treatment will use the app or receive usual care. Researchers will …

This study planned to test a device called NovoTTF-200A (which uses electric fields to disrupt cancer cells) together with the drug pembrolizumab in people with melanoma that had spread to the brain. The goal was to see if the combination was safe and effective. However, the stud…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests whether creating a personal music playlist can help people process grief after losing a spouse or life partner. Thirty participants from a grief support group will work with a researcher to build a playlist and reflect on their experience. The goal is to see if m…

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

This study in Sierra Leone tests whether using mobile phones to supervise teachers can improve how they deliver a mental health program called the Youth Readiness Intervention (YRI) to students. About 1,454 youth and their teachers from secondary schools will take part. The YRI i…

This study looks at whether a special support program, called CLASP, can help prevent suicide and related behaviors in veterans who are at high risk after leaving the hospital. About 850 veterans will be randomly assigned to either usual care or usual care plus the CLASP program,…

This study tests whether machine learning can predict which HIV patients are likely to miss clinic visits or have treatment failure. Researchers will give clinic workers risk alerts to help them reach out to high-risk patients. The goal is to improve retention in care and viral s…