New immunotherapy cocktail aims to beat melanoma relapse
NCT ID NCT02656706
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests a combination of two immunotherapy drugs, nivolumab and low-dose ipilimumab, given after surgery to patients with stage III or resected stage IV melanoma. The goal is to see if this regimen is safer and more effective than standard high-dose interferon, which is highly toxic. The study enrolled 22 participants and will track side effects and survival outcomes over six months of treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nivolumab and ipilimumab (immunotherapy drugs)
What this could lead to
If successful, this combination could offer a more effective and less toxic adjuvant treatment for high-risk melanoma, potentially increasing the chance of long-term remission.
What could go wrong
This is a small phase II trial with only 22 participants, so results may not apply broadly. The drugs can cause serious immune-related side effects, and it is unclear if the combination will be better than existing options.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Rhode Island Hospital and The Miriam Hospital
Providence, Rhode Island, 02903/02906, United States