Could a Six-Month exercise and diet plan shield muscle during melanoma treatment?

This trial tests whether a six-month program of supervised resistance exercise and personalized nutritional support can help adults with stage II to IV melanoma preserve muscle mass and quality while starting immunotherapy. Participants are randomly assigned to either the exercise and nutrition program alongside standard cancer care, or standard care alone. The study tracks changes in thigh muscle volume, fat infiltration, body composition, fatigue, and treatment tolerance over six months. The goal is to see if this supportive approach can reduce muscle loss and improve outcomes during immunotherapy.