E-Cigs vs. nicotine patches: which helps obese smokers kick the habit?

NCT ID NCT06948058

Recruiting now Disease control Sponsor: Brown University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbon monoxide levels, and any weight changes. The goal is to find a safer way to stop smoking without causing major weight gain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electronic cigarettes and nicotine replacement therapy (patches and lozenges)
What this could lead to: If successful, this could point toward a practical way for obese smokers to quit cigarettes without gaining excessive weight.
What could go wrong: This is a small, early-stage study with only 60 participants, so results may not apply to everyone. E-cigarettes have their own health risks and are not FDA-approved for smoking cessation.

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Conditions

The condition(s) this trial relates to.

Harm Reduction nicotine dependence Obesity obesity disorder Smoking Cessation Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY AND OBESITY-RELATED MEDICAL CONDITIONS SMOKING CESSATION

Contacts and locations

Locations

Brown University
RECRUITING

Providence, Rhode Island, 02912, United States

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