LUNG NEOPLASMS

This study is testing a new medicine called PF-08634404 for adults with early-stage or locally advanced non-small cell lung cancer. Researchers want to see if the drug works better when given alone or with chemotherapy, either before surgery or after other treatments. The trial w…

This study is testing whether a new medicine called PF-08634404 works better when given with standard chemotherapy for a rare, aggressive form of lung cancer called transformed small cell lung cancer. The trial will enroll 40 adults who haven't received treatment for this specifi…

This study is testing whether inhaling a gene therapy drug called Gendicine can safely shrink or control multiple early-stage lung nodules. It will enroll about 38 adults with these nodules, which are often precancerous or early cancer. All participants will receive the inhaled t…

This study is testing a new computer tool that creates a 3D model of a patient's lungs before lung cancer surgery. Doctors will use this model to perform a 'virtual surgery' to predict how well the patient's lungs will work after the real operation. The goal is to give surgeons a…

This large study aims to find out if a newer anesthesia method, where patients breathe on their own with a mask and nerve blocks, is as safe as the traditional method using a breathing tube and ventilator during a specific type of lung surgery. It will enroll about 1,600 patients…

This study aims to learn if analyzing immune cells from a patient's lung fluid, along with a standard tumor marker (PD-L1), can better predict how well someone with advanced lung cancer will respond to treatment. Researchers will collect lung fluid and tumor tissue from 60 patien…