Can a Heat-and-Freeze treatment plus a vaccine outsmart pancreatic cancer?

This phase 2 trial is testing a novel combination for people with metastatic pancreatic cancer that has progressed after standard first-line chemotherapy. The approach combines a device that alternately freezes and heats the tumor (multimodal thermal therapy) with a personalized mRNA vaccine targeting the KRAS G12V mutation, the chemotherapy drug S-1, and the immunotherapy sintilimab. The study aims to see if this combination is safe, tolerable, and potentially effective in slowing the disease, while also exploring how it affects the immune system.