LUNG NEOPLASMS

This program offers taletrectinib to adults with advanced or spreading ROS1-positive non-small cell lung cancer who cannot use approved treatments or join ongoing studies. Participants must have a ROS1 gene fusion and adequate organ function. The goal is to provide potential bene…

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutated non-small cell lung cancer. About 532 adults with stage IIIB, IIIC, or IV lung cancer that cannot be surgically removed are being observ…

This study tests a new way to give proton radiation for stage II-III non-small cell lung cancer. Instead of daily treatments over many weeks, patients receive higher doses over a shorter time (hypofractionation) along with standard chemotherapy. The goal is to find the safest hig…

This early-phase study tests a new treatment called KSQ-001EX for people with advanced solid tumors (melanoma, lung, or head/neck cancers) that have not responded to standard therapy. The treatment involves taking a patient's own tumor-fighting immune cells, modifying them in a l…

This study compares a new approach using cone-beam CT and robotic-assisted bronchoscopy against standard methods for taking lung tissue samples. The goal is to see if the new technique improves the chance of getting a clear diagnosis for lung cancer or other lung diseases. About …

This study tests a new technology that automatically adjusts the radiation beam to follow a lung tumor as it moves with breathing. Twenty adults with early-stage lung cancer or limited lung metastases will receive standard radiotherapy with this tracking system. The main goal is …

This study looks at circulating tumor cells (CTCs) in the blood of people with advanced lung cancer. The goal is to learn about DNA repair problems in these cells and test new drugs in the lab. About 80 participants will give blood samples to help researchers understand how to pe…

This study looks at whether educating doctors in smaller city and county hospitals can improve how they test and treat patients with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more patients get the right molecular tests and targeted therap…

This study looks at whether special CT scans (4DCT) can help doctors avoid giving too much radiation to healthy parts of the lungs during lung cancer treatment. Researchers will compare two types of radiation plans using data from 202 patients who already had treatment. The goal …