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New imaging technique may reduce lung damage from cancer radiation

NCT ID NCT07312682

Knowledge-focused Sponsor: The Second Affiliated Hospital of Chongqing Medical University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether special 4DCT scans can help doctors avoid damaging healthy lung tissue during radiation therapy for lung cancer. Researchers will compare standard radiation plans with ones that use lung function maps to spare well-working lung areas. The study uses existing data from 202 patients and does not involve any new treatments or procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

202 people

The number who actually took part.

Started

Dec 2024

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Single-center retrospective cohort of consecutive adults (≥18 years) with primary lung cancer treated with thoracic radiotherapy planned with IMRT, with adequate 4DCT scans for ventilation mapping (2022-01-01 to 2025-09-09).

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically confirmed primary lung cancer (adenocarcinoma, squamous cell carcinoma, or small-cell carcinoma) treated with thoracic radiotherapy. * High-quality 4DCT scans performed before radiotherapy, enabling generation of ventilation or perfusion maps. * Radiotherapy plans designed using IMRT. * Availability of both functional lung avoidance plans and conventional anatomical radiotherapy plans for paired analysis. * Complete treatment and follow-up records, including radiation-induced lung injury (e.g., radiation pneumonitis) and pulmonary function tests. Exclusion Criteria: * Incomplete or poor-quality imaging data preventing accurate ventilation/perfusion map generation. * Radiotherapy interrupted or incomplete for any reason. * Severe underlying lung diseases (e.g., extensive emphysema, pulmonary fibrosis, active tuberculosis) that may confound treatment outcomes or toxicity assessment. * Presence of other untreated primary malignancies during the study period. * Prior lung surgery or local therapies (e.g., ablation) that may affect evaluation of radiation-induced lung injury. * Missing follow-up data, making assessment of radiation-induced lung injury or long-term lung function changes impossible.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm radiation pneumonitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung neoplasms Radiation pneumonitis

Contacts and locations

Locations

  • Cancer Center, Second Affiliated Hospital of Chongqing Medical University

    Chongqing, 400000, China

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