New hope for rare lung cancer: experimental drug combo enters human trials
NCT ID NCT07476287
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new medicine called PF-08634404 given with chemotherapy for adults with transformed small cell lung cancer (T-SCLC), a rare and aggressive cancer that develops from another lung cancer type. About 40 participants will receive the drug combo through IV infusions, then continue the study drug alone. The main goal is to see if tumors shrink and to check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PF-08634404 (also called SSGJ-707) given with chemotherapy
What this could lead to
If it works, this could offer a new treatment option for people with transformed small cell lung cancer, a rare and aggressive cancer that currently has few options.
What could go wrong
This is an early Phase 2 trial with only 40 participants, so results may not apply to everyone. The drug may not shrink tumors or could cause side effects like those from chemotherapy.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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City of Hope Lennar Foundation Cancer Center
RECRUITINGIrvine, California, 92618, United States
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City of Hope National Medical Center
RECRUITINGDuarte, California, 91010, United States
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Hope and Healing Clinical Research
RECRUITINGHinsdale, Illinois, 60521, United States
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Hope and Healing Clinical Research
RECRUITINGNew Lenox, Illinois, 60451, United States
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Japanese Foundation for Cancer Research
RECRUITINGKotoku, Tokyo, 135-8550, Japan
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National Cheng Kung University Hospital
NOT_YET_RECRUITINGTainan, 704302, Taiwan
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National Taiwan University Hospital
NOT_YET_RECRUITINGTaipei, 100, Taiwan
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Peking Union Medical College Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100730, China
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Shaare Zedek Medical Center
RECRUITINGJerusalem, Jerusalem, 9103102, Israel
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Shanghai Chest Hospital
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200030, China
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Sheba Medical Center
RECRUITINGRamat Gan, HA Merkaz, 5265601, Israel
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
NOT_YET_RECRUITINGWuhan, Hubei, 430048, China