Urinary bladder disorder

This early study is testing a new approach for people whose bladders have become small and scarred, causing frequent urination and discomfort. Doctors will take a small sample of the patient's own bladder cells, grow them in a lab on a special scaffold to create a 'neo-bladder' p…

This phase 2 trial tests whether giving focused radiation (SBRT) along with immunotherapy drugs (cemiplimab, with or without fianlimab) before bladder removal can safely shrink muscle-invasive bladder tumors. The study enrolls 44 patients who cannot or choose not to take standard…

This early-phase trial tests a combination of three drugs—enfortumab vedotin, pembrolizumab, and quemliclustat—in people with advanced bladder or urinary tract cancer that has spread or cannot be removed by surgery. The goal is to see if the combination is safe and effective. The…

This phase II trial compares a new targeted drug, sacituzumab tirumotecan (Sac-TMT), to other antibody-drug conjugates (ADCs) in people with advanced urothelial carcinoma (bladder cancer) that has worsened after prior treatment. The main goal is to see if Sac-TMT causes less seve…

This phase 2 trial tests whether a combination of two drugs—enfortumab vedotin (Padcev) and pembrolizumab (Keytruda)—can help people with muscle-invasive bladder cancer avoid bladder removal. About 56 participants will receive the drugs first, and those who respond well may get r…

This early-phase trial tests whether a combination of stem cell exosomes and sodium hyaluronate, instilled directly into the bladder, can safely treat radiation cystitis—a painful condition causing bleeding and urinary problems after pelvic radiotherapy. 48 women aged 18-80 will …

This study looks at whether using ureteral stents (small tubes) after bladder cancer surgery leads to more or fewer problems than not using them. About 190 adults having their bladder removed will be randomly assigned to get stents or not. The main goal is to see who ends up back…

This early-phase trial tests whether adding radiation therapy or bladder removal surgery can safely eliminate remaining cancer in patients with advanced bladder cancer who have already responded to a drug combination. The study enrolls 12 adults with muscle-invasive bladder cance…

This early-phase trial tests a new treatment called LB-DTK-BKV for people who develop painful bladder bleeding (hemorrhagic cystitis) from BK virus after a stem cell transplant. The treatment uses immune cells from a donor that are trained to attack the virus. About 42 children a…

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study tests whether combining two drugs (trastuzumab rezetecan and camrelizumab) before surgery can improve outcomes for people with a certain type of muscle-invasive bladder cancer (HER2-positive). About 44 adults will receive the treatment to see if it helps eliminate canc…

This phase 2 trial tests a combination of two drugs, enfortumab vedotin and pembrolizumab, given before surgery to people with muscle-invasive bladder cancer or upper tract urothelial carcinoma. The goal is to see if the drugs can shrink or eliminate the cancer enough that some b…

This study is testing a new device called ARTUS® that acts like an artificial muscle to control urine leakage in women with severe stress urinary incontinence. Six women who have not gotten better with other treatments will get the device implanted and be followed for two years. …

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

This early-stage trial tests a new drug called ATO-101 for a type of bladder cancer that hasn't responded to standard treatments. The drug delivers a short-range radioactive particle directly into the bladder to kill cancer cells while sparing healthy tissue. About 24 patients wi…

This study looks at people with a very high-risk type of bladder cancer that cannot be fully removed with standard surgery. After initial treatment with immunotherapy and surgery, some patients become tumor-free. The trial then randomly assigns them to either continue immunothera…

This Phase 3 trial is testing whether a combination of an experimental drug (SHR-1501) plus the standard immunotherapy BCG works better than chemotherapy for people with a type of bladder cancer (papillary-only NMIBC) that no longer responds to BCG alone. The study plans to enrol…

This study tests whether giving two drugs (trastuzumab rezetecan and adebrelimab) before surgery can eliminate or shrink tumors in people with a specific type of muscle-invasive bladder cancer (HER2-positive). About 58 adults will receive the combination, then have their bladder …

This study tests whether a combination of disitamab vedotin (a targeted drug) and toripalimab (an immunotherapy) works better than standard chemotherapy plus immunotherapy for people with HER2-positive muscle-invasive bladder cancer. About 240 participants will receive treatment …

This study tests a treatment called HIVEC, which delivers heated chemotherapy directly into the bladder. It is for people with a type of bladder cancer that has not responded to standard therapy and who cannot have their bladder removed. The goal is to see if this approach is saf…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This early-stage trial tests a procedure called calcium electroporation for bladder tumors. Doctors inject calcium into the tumor and then apply short electric pulses to destroy cancer cells. The study will include 20 patients who cannot have standard surgery or other treatments.…

This study compares two treatments for stress urinary incontinence (leaking urine when you cough, sneeze, or exercise). One group gets a shot of platelet-rich plasma (PRP) made from their own blood, while the other gets a standard surgical sling. The trial will enroll 42 women an…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This study tests whether adding a probiotic (Clostridium butyricum) to a combination of targeted therapy (Disitamab Vedotin) and immunotherapy (Toripalimab) can help preserve the bladder in people with muscle-invasive bladder cancer who cannot take the chemotherapy drug cisplatin…

This early-stage trial tests a new drug called JL19001, given alone or with standard BCG therapy, in 18 people with high-risk non-muscle invasive bladder cancer. The main goals are to check safety, find the right dose, and see how the body handles the drug. It's a first step to s…

This Phase 3 trial tests NDV-01, a sustained-release combination of two chemotherapy drugs (gemcitabine and docetaxel), given directly into the bladder. It aims to prevent cancer from coming back in people with non-muscle invasive bladder cancer, including those who have not resp…

This study tests a new treatment called HS-10566, a gel that delivers the chemotherapy drug gemcitabine directly into the bladder. It is for people with high-risk non-muscle-invasive bladder cancer who cannot or choose not to have their bladder removed. The trial will check if th…

This early-phase trial tests a new biologic drug called SPGL008, given alone or with the standard therapy BCG, in 120 people with high-risk non-muscle-invasive bladder cancer who are not candidates for bladder removal. The main goals are to find a safe dose and see if the drug ca…

This study tests whether adding immunotherapy (toripalimab) to standard chemotherapy before surgery can improve outcomes for people with muscle-invasive bladder cancer. About 30 participants will receive the combination therapy, and researchers will monitor how the tumor and immu…

This study looks at whether veterans with early-stage high-grade bladder cancer can have fewer follow-up exams (cystoscopies) without harming their health. About 2,500 participants will be randomly assigned to either a low-intensity or high-intensity surveillance schedule. The go…

This study compares two treatments for muscle-invasive bladder cancer: radiation combined with chemotherapy versus surgery to remove the bladder. About 336 adults with this cancer will be randomly assigned to one of the two groups. The goal is to see if the non-surgical approach …

This study tests whether mirabegron, a drug used for overactive bladder, can help people with dry age-related macular degeneration (AMD). Researchers will give 312 patients aged 50-80 either mirabegron or a standard bladder drug for 12 months and check for changes in the retina. …

This phase 2 trial tests a virus-based drug given directly into the bladder for people with high-risk non-muscle invasive bladder cancer. The virus is designed to attack cancer cells and trigger the immune system. About 18 participants will receive increasing doses to find the sa…

This trial tests a new way to remove kidney stones using a special laser and a flexible suction sheath. 140 adults with stones between 6mm and 20mm will be randomly assigned to get the new suction sheath or a standard sheath. The goal is to see if the new method clears more stone…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This phase 2 trial tests a combination of two drugs (toripalimab and RC48-ADC) plus radiation in 45 people with HER2-positive muscle-invasive bladder cancer. The goal is to see if this approach can eliminate the cancer and allow patients to keep their bladder after initial chemot…

This early study tests a new treatment called Plasma-Activated Saline Solution (PASS) for bladder cancer. Five patients will receive a one-week course of PASS infused directly into the bladder before their scheduled surgery. Researchers will check if the treatment shrinks tumors …

This phase 3 trial compares radiotherapy with a radiosensitiser to the standard BCG immunotherapy for high-risk non-muscle invasive bladder cancer. About 328 patients will be randomly assigned to one of the two treatments after tumor removal. The goal is to see which approach bet…

This study tests a new combination of the drug entinostat plus standard chemotherapy for people with advanced bladder cancer that has spread or cannot be removed by surgery and has not responded to first-line treatment. About 29 participants will receive the combination to see if…

This study follows 16 people who already received EG110A, a gene therapy that uses a modified herpes virus to deliver a botulinum toxin-like protein to relax bladder muscles. Researchers will track side effects and how well the treatment works over five years. The goal is to see …

This phase 2 trial tests whether a drug called N-803, combined with either BCG or gemcitabine, can treat intermediate-risk bladder cancer without needing surgery. About 20 adults with low-grade papillary tumors will receive the drugs directly into the bladder. The main goal is to…

This study tests whether adding the drug disitamab vedotin to standard BCG therapy can help keep high-risk, early-stage bladder cancer from returning. It includes 182 adults whose cancer has been surgically removed but is at high risk of coming back. Participants will receive eit…

This early study will test a new type of immune cell therapy in 20 people with advanced bladder cancer that hasn't responded to standard treatments. The therapy uses the patient's own γδ-T cells, which are grown in a lab and then infused back to attack the cancer. The main goal i…

This study tests whether injecting the chemotherapy drug gemcitabine directly into the bladder wall can prevent cancer from coming back in people with intermediate- or high-risk non-muscle-invasive bladder cancer. About 320 participants will receive either the new injection or th…

This study tests whether two drugs, Vedisertib and Toripalimab, can shrink muscle-invasive bladder cancer so patients can keep their bladder. About 59 adults with early-stage cancer will receive the drugs in cycles, with regular checks to see if the cancer disappears. If it does,…

This study tests whether a treated umbilical vein graft can effectively treat stress urinary incontinence in women, comparing it to the standard sling made from the patient's own tissue. About 96 women will receive one of the two surgical treatments and be followed for a year. Th…

This study tests whether adding chemotherapy drugs (gemcitabine and mitomycin C) directly into the bladder alongside an immune-boosting drug (toripalimab) works better than toripalimab alone for people with a high-risk bladder cancer that did not respond to standard BCG therapy. …

This phase 2 trial tests a dose-dense (faster) schedule of two chemotherapy drugs, gemcitabine and cisplatin, given before surgery for muscle-invasive bladder cancer. The goal is to see if this approach can completely eliminate the tumor in the bladder and lymph nodes. Thirty eli…

This phase 2 trial tests two drugs—disitamab vedotin and toripalimab—as a way to treat HER2-positive muscle-invasive bladder cancer without removing the bladder. About 60 adults with locally advanced cancer will receive different cycles of the combination. The main goal is to see…

This early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. …

This study will test an artificial intelligence system that screens for breast, liver, kidney, and bladder cancers using standard CT scans taken for other reasons. Researchers plan to enroll 100,000 participants to see if the AI can catch tumors earlier and help doctors reduce mi…

This study aims to develop a new urine test for schistosomiasis, a parasitic infection. Researchers will test a nanobody-based strip on 2500 participants, comparing it to the standard microscope method. If accurate, it could offer a quick, non-invasive diagnostic tool.

This study explores whether analyzing tumor DNA in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to see if the test can detect cancer mutations and track change…

This study compares two imaging tests—PIC cystography and VCUG—for diagnosing vesicoureteral reflux (VUR) in children. VUR is a condition where urine flows backward from the bladder to the kidneys, which can lead to infections. The trial will enroll 60 children undergoing endosco…

This study tests a urine test (Xpert Bladder Cancer Detect) to see if it can accurately identify people with hidden blood in their urine who are at higher risk for bladder cancer. About 1,475 adults over 40 will provide a urine sample and answer symptom questionnaires, then under…

This study tests whether a special PET scan (FAPI PET) and simple urine tests can better determine the stage of bladder cancer compared to standard methods. About 262 adults with bladder cancer will receive the scan and provide urine samples before treatment. The goal is to see i…

This study tests whether a daily probiotic supplement called Colipral® can prevent repeat bladder infections (cystitis) in menopausal women aged 55–70. Participants take either the probiotic or a placebo for 12 weeks and are monitored for 24 weeks to see if they have fewer infect…

This study looks at whether giving women a single dose of antibiotics right before a clinic-based urethral bulking procedure (for stress incontinence) can lower their chance of getting a urinary tract infection afterward. About 150 women will be split into two groups: one gets th…

This study looks at whether the position a woman gives birth in (lying on her back, upright, or on her side) can help prevent stress urinary incontinence (leaking urine when coughing or sneezing) after childbirth. Researchers will follow 669 first-time mothers, ages 20-35, who pl…

This study tests whether adding core muscle exercises to standard pelvic floor training can better reduce urinary incontinence. Fifty adults with stress or mixed incontinence will do 12 weeks of exercises, either standard or with core co-activation. Researchers will measure sympt…

This study tests a new at-home device called the Floora Pelvic Rehabilitation Vaginal Dilator in 10 women with interstitial cystitis (painful bladder syndrome) and high-tone pelvic floor dysfunction. Participants use the device three times a week for 12 weeks, combining heat and …

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study will test two different pelvic floor exercise techniques in 40 women aged 30-40 with stress urinary incontinence (leaking urine during activities like coughing or exercise). One group will do exercises in gradually harder positions, while the other will use gradually h…

This study investigates whether adding low-intensity shockwave therapy to standard Kegel exercises can better reduce urine leakage in women with stress urinary incontinence. Participants will either do Kegels alone or Kegels plus weekly shockwave sessions for eight weeks. The goa…

This study tests whether giving patients a standing prescription for antibiotics to use at the first sign of a UTI after Botox for overactive bladder reduces unplanned healthcare visits. 260 women scheduled for Botox will either get the self-start prescription or follow standard …

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This study tests whether stimulating a nerve near the ankle, called percutaneous tibial nerve stimulation (PTNS), can safely treat overactive bladder in children aged 5 to 21. The treatment uses a device called Urgent PC that sends weak electrical signals through a thin needle to…

This study tests whether electroacupuncture (thin needles with mild electrical pulses) can help women with overactive bladder who haven't improved with standard treatments. Thirty-two women will receive either electroacupuncture, a nerve stimulation therapy, or a sham (fake) acup…

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study will test whether a wearable device that stimulates a nerve in the leg can help women with overactive bladder and frequent nighttime urination. Participants will either use the device plus behavioral therapy or behavioral therapy alone. The goal is to see if the device…

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

This study tests whether watching a virtual reality (VR) video before kidney stone surgery can lower anxiety, boost knowledge, and improve self-care. About 90 adults scheduled for surgery will be split into three groups: standard education, standard VR, or a special VR with built…

This study tests whether combining traditional Chinese five-element music therapy with herbal acupoint patches can reduce pain and anxiety in people undergoing kidney stone surgery under local anesthesia. Sixty adults with small kidney stones will be randomly assigned to receive …

This early-stage study will give 20 bladder cancer patients cannabigerol (CBG) gummies before and after surgery to see if they are safe and tolerable. The goal is to improve quality of life and reduce symptoms during recovery. Researchers will monitor side effects and how well pa…

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This study tests a device called Tensi+ that uses mild electrical pulses to a nerve in the ankle to treat overactive bladder symptoms like sudden urges and frequent bathroom trips. About 60 adults with these symptoms will use the device at home for 12 weeks. The goal is to see if…

This study tests a new method to deliver botulinum toxin (NT 201) directly into the bladder using the Vibe System for women with overactive bladder. The goal is to reduce daily urine leakage episodes. About 210 women aged 18-80 will participate, and the treatment is compared to a…

This study tests whether a small, portable nerve stimulation device worn at home can reduce urgent bathroom trips in people with overactive bladder. Sixty adults aged 18 to 65 will either use the device during daily life when they feel urgency or receive standard clinic-based ses…

This study compares two non-invasive treatments—magnetic field therapy and tibial nerve stimulation—for women with urge urinary incontinence (sudden, strong urges to urinate leading to leaks). Forty women will be randomly assigned to one of the two treatments over six weeks. Rese…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests whether high-intensity focused ultrasound (HIFU) can safely and effectively treat urinary symptoms caused by an enlarged prostate. Seventeen men aged 45 to 80 with moderate to severe symptoms will receive a single HIFU treatment using a probe placed in the rectum…

This study tests two treatments—mirabegron (a drug) and exercise-based behavioral therapy—for overactive bladder in people with Parkinson's disease. Researchers want to see if combining treatments helps those who don't respond to one alone. The trial will involve 146 participants…

This study tests whether adding pulsed electromagnetic field (PEMF) therapy to standard bladder instillations of heparin and bupivacaine can better reduce chronic pelvic pain in women with interstitial cystitis/bladder pain syndrome. Twenty female adults who already receive bladd…

This study tests a device called VTone that uses gentle electrical pulses inside the vagina to strengthen muscles and reduce stress urinary incontinence (leaking when coughing, sneezing, or exercising). Fifteen women will receive 8 weekly treatments and be followed for 3 months. …

This study tests whether using virtual reality (VR) during pelvic floor exercises helps women who leak urine after childbirth. Fifty women, ages 22-35, who had a vaginal delivery 3-6 months ago will be randomly assigned to standard training or VR-enhanced training. The goal is to…

This study looks at whether a new device (Neuspera SNM System) works better than older devices for people with sudden, strong urges to urinate. About 100 adults who already have a traditional bladder control device will get the new one and answer questions about their symptoms. T…

This study tests whether adding gabapentin to the standard drug solifenacin works better than solifenacin alone for women with overactive bladder. Sixty women will be randomly assigned to one of the two treatments and followed for 3 months. The goal is to see if the combination i…

This study tests a new treatment called TRG-200 KIT for people with overactive bladder (OAB) who haven't found relief from standard therapies. The treatment is given once a month through a catheter into the bladder and slowly releases medication to reduce urgent bathroom trips an…

This study tests whether a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will receive either the gas plus standard numbing medicine or a sham mask plus standard care. Participa…

This study looks at whether giving standard bladder cancer drugs in the morning or afternoon changes how well they work and how many side effects they cause. About 224 adults with advanced bladder cancer will be randomly assigned to receive their treatment either before 11:30 a.m…

This study tests whether adding blood flow restriction (using a cuff to partially reduce blood flow to the thighs) to standard pelvic floor muscle training can better reduce stress urinary incontinence in postmenopausal women. Sixty women with mild to moderate leakage will be spl…

This study tests a newer, more precise radiation method (adaptive radiotherapy) for people with muscle-invasive bladder cancer who cannot have surgery or choose not to. The goal is to see if this technique reduces bowel side effects like diarrhea compared to standard radiation. A…

This study tests if a gentle heat treatment (45-50°C) delivered through the vagina can calm overactive bladder symptoms. The heat targets nerve endings in the bladder muscle to reduce urgency and leakage. About 48 adults with moderate to severe symptoms will receive this office-b…

This study tests whether adding a non-invasive electromagnetic chair treatment (HIFEM) to standard pelvic floor training can better reduce urine leakage in women aged 65-85 with daily stress incontinence. One hundred participants will be randomly assigned to either pelvic floor t…

This study tests a behavioral program to help women who have had pelvic radiation use vaginal dilators more regularly. Dilators can prevent or treat vaginal narrowing that makes exams or sex painful. 88 women will be randomly assigned to either the program (with coping strategies…

This study tests whether small changes—like playing calming music, showing a relaxing video, or giving numbing gel at the right time—can reduce pain and anxiety during a bladder cancer exam or treatment. About 378 adults with bladder cancer will be randomly assigned to receive on…

This study tests whether a video call with a family member while waiting in the operating room can lower stress, anxiety, and fear in patients having bladder tumor surgery. About 124 adults will be randomly assigned to either have a video call or receive standard care. Researcher…

This study looks at whether adding pelvic floor muscle training to vaginal estrogen therapy helps postmenopausal women with stress urinary incontinence more than estrogen alone. About 115 women will be randomly assigned to either the combined treatment or estrogen-only group. The…

This study compares four surgical techniques for removing bladder stones in patients who have a continent catheterizable urinary reservoir, a surgically created pouch that stores urine. The techniques include using a mini-percussion device through the stoma, a flexible scope thro…

This study will test four different water-drinking plans in 20 healthy women to see which one gives the best bladder filling for a pelvic ultrasound. Participants will drink different amounts of water on different days, and researchers will measure bladder volume and comfort. The…

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This study will use millimeter-wave radar to measure how the pelvic floor muscles move in 2,000 women, both healthy and those with stress urinary incontinence. The goal is to create a large database of normal movement patterns and build a standard assessment system. This is an ob…

This study will test a mobile app version of a bladder diary in 40 Portuguese adults with overactive bladder or urinary incontinence. Participants will use the app for one month and then answer questions about how easy it was to use and whether they prefer it over paper diaries. …

This study aims to learn what it's truly like to live with overactive bladder (OAB) by asking 2000 adults in eight European countries about their daily activities, emotional health, social life, and work. Participants complete surveys about their symptoms and quality of life. The…

This study looks at whether a special CT measurement, called the URSL Predictive Angle, can help doctors know ahead of time if a kidney stone surgery might need to switch to a different method during the procedure. Researchers will review records from 2,200 patients who had this …

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study will test a special AI program called UroMed AI Doctor, designed to help with urology care. Researchers will compare AI-assisted care to traditional care from a specialist for patients with kidney stones, enlarged prostate, or bladder cancer. The goal is to see if the …

This study looks at whether reading a short educational flyer helps women learn more about stress urinary incontinence (SUI). About 90 adult women visiting a urogynecology clinic will fill out a quiz before and after reading the pamphlet. The goal is to see if the pamphlet improv…

This study examines two microscopic details in bladder cancer tumors—how deep early cancer cells have invaded and whether small clusters of cells are present at the tumor's edge. Researchers will look at tissue samples from 100 patients to see if these features can predict if the…

This study looks for biological markers that can predict bladder injury caused by radiation therapy. Researchers will collect samples from 220 adults who receive high-dose abdominal radiation. The goal is to create a model that helps doctors identify patients at risk before serio…

This study examines stored tumor samples from 100 bladder cancer patients who had their bladder removed. Researchers will measure the amount of supportive tissue, immune cells, and immune clusters near the tumor. The goal is to see if these features are linked to how long patient…

This study looks at whether three proteins in urine—RhoA, NGF, and BDNF—can help doctors diagnose and monitor overactive bladder in children aged 4 to 18 who also have low vitamin D. Researchers will measure these proteins before and after standard behavioral therapy (urotherapy)…

This study will follow 300 people with non-spreading bladder cancer who receive high-dose radiation therapy (with or without a chemotherapy booster). Researchers want to see how long patients live, how often the cancer returns in the bladder or elsewhere, and what side effects oc…

This study will translate and test a questionnaire called USIQ, which measures how severe urinary urgency is and how it affects daily life, for Turkish-speaking women with overactive bladder. Researchers will enroll 130 women and compare their answers on the USIQ with other stand…

This study aims to find out what factors help predict a successful outcome after a type of prostate surgery called HoLEP, which treats an enlarged prostate. Researchers will follow 604 men aged 40 and older who are scheduled for HoLEP. They will measure success based on symptom r…

This study will follow 600 people with early-stage solid cancers (like lung, head and neck, melanoma, or bladder cancer) who are receiving immunotherapy before surgery. Researchers will collect blood and tumor samples at several time points to see how the immune system responds. …

This study looks at whether a protein called CTGF in urine can indicate bladder scarring and predict how well men recover after surgery for an enlarged prostate. Researchers will measure CTGF levels before surgery in 50 men and compare them to their outcomes. The goal is to find …

This study will test a new classification system (BICEP) to grade bladder injuries that happen during a common surgery for bladder cancer called TURBT. Researchers will observe 1,000 patients to see how often injuries occur, how severe they are, and how doctors manage them. The g…

This study looks at whether people with overactive bladder can be monitored at home after receiving botulinum toxin injections, instead of going to the hospital. About 112 participants will be randomly assigned to either home or hospital follow-up. The goal is to see if home moni…

This study looks at how age and sex influence pain before and after a first-time flexible cystoscopy (a thin tube inserted into the bladder). Researchers will ask 150 adults to rate their expected and actual pain using a simple 0-10 scale. The goal is to better understand who mig…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will compare gut bacteria and blood markers between 270 kidney stone patients and healthy people in Shanghai. Researchers want to see if hot, humid weather changes gut microbes and tryptophan metabolism in ways that promote stone formation. No treatment is given; the g…

This study will compare two different EMG methods (surface and intravaginal) and digital palpation to measure pelvic floor muscle strength in 24 women with stress urinary incontinence. The goal is to see if the methods give different results. This is an observational study, not a…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…

This observational study will follow 150 adults with early-stage bladder cancer to see if factors like muscle loss, fat distribution, and nutrition affect the chance of cancer coming back or getting worse. Participants will have standard treatments and extra assessments including…

This study will look at 1,100 older women in Hong Kong, including 1,000 with urinary incontinence and 100 without, to better understand the condition. Researchers will explore how common different types of incontinence are, what traditional Chinese medicine patterns appear, and w…

This study reviews medical records of 87 adults with muscle-invasive bladder cancer who received platinum-based chemotherapy before surgery. Researchers want to see what factors influence how well the chemo works and whether it helps patients live longer without cancer. The goal …

This study will follow 200 women who are either taking GLP-1 weight loss drugs or undergoing bariatric surgery. Researchers want to see how these treatments change pelvic floor symptoms like incontinence and prolapse. Participants do not need to have any pelvic floor symptoms to …