New drug could replace opioids for Post-Surgery pain

NCT ID NCT07600697

Not yet recruiting Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see if suzetrigine reduces opioid use and side effects while still managing pain effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Suzetrigine
What this could lead to: If it works, this could offer a safer, non-addictive painkiller option for women recovering from pelvic surgery.
What could go wrong: This is a small, early-phase trial (120 people) testing non-inferiority, so it may not prove suzetrigine is as good as opioids. Side effects or lack of pain control are possible.

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Conditions

The condition(s) this trial relates to.

female stress incontinence Pain, Postoperative pelvic organ prolapse Urinary Incontinence, Stress

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PELVIC ORGAN PROLAPSE (POP) POSTOPERATIVE PAIN STRESS URINARY INCONTINENCE (SUI)

Contacts and locations

Locations

University of California, Los Angeles (UCLA)

Los Angeles, California, 90095, United States

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