Pelvic organ prolapse

This trial tests a new surgical method to treat pelvic organ prolapse in women having a hysterectomy. The surgeon uses special ligaments to support the vaginal vault. Ten women will take part, and the study will measure how much the prolapse improves.

This study compares a new barbed suture (SYMMCORA) with a standard one (V-Loc) for closing the vaginal cuff after laparoscopic hysterectomy. The goal is to see if the new suture reduces stitching time without increasing complications. About 132 women having elective laparoscopic …

This study compares two surgical approaches for women with urogenital prolapse but without significant posterior vaginal wall prolapse. One group receives a single mesh in the front, while the other gets an additional mesh in the back as a preventive measure. The goal is to see i…

This study compares two laparoscopic surgeries for apical prolapse, a common condition in aging women. The standard surgery, sacrocolpopexy, is effective but technically challenging. The newer pectopexy may be safer and faster to learn. Thirty women with advanced prolapse will be…

This study compares two common surgeries for uterine prolapse (when the womb drops down). About 426 women will be randomly assigned to have either a Manchester procedure or a vaginal hysterectomy. Researchers will track success rates, symptom relief, and quality of life for up to…

This study compares a new surgical technique called transobturator cystocele repair (TOCR) to the standard anterior repair for fixing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. About 592 women aged 50 and older with at least stage 2 pro…

This study compares two surgical methods using mesh to treat pelvic organ prolapse in women. One approach uses vaginal mesh, the other uses robotic-assisted abdominal mesh. The goal is to see if vaginal mesh works as well as the robotic method and is just as safe. About 86 women …

This study tests whether a new biological mesh (OviTex) works better than the standard synthetic mesh for women having robotic surgery for pelvic organ prolapse. About 184 participants will be followed to compare complications and symptom relief. The goal is to find a safer and m…

This study tests whether a pelvic floor muscle training program, delivered through a mobile app, can reduce urinary incontinence and other pelvic floor disorders after childbirth. About 734 first-time pregnant women will either follow the app-based training or receive standard ca…

This study tests two surgical techniques to fix vulvovaginal gaping, a condition that can cause discomfort and sexual problems. One hundred women with genital prolapse will be randomly assigned to either a newer muscle-plication surgery or a standard repair. The goal is to see wh…

This study is testing a device called Anchorsure, used during surgery to fix pelvic organ prolapse (when organs like the uterus or bladder slip down). The device is meant to make the surgery faster, with less pain and fewer nerve injuries. Researchers will follow 120 women for 3 …

This study compares two types of mesh surgery for women with pelvic organ prolapse after a hysterectomy. One surgery uses a mesh placed through the vagina, the other uses a mesh placed through small cuts in the belly (laparoscopic). The main goal is to see which surgery works bet…

This study compares two laparoscopic surgeries—lateral suspension and sacrocolpopexy—for women with vaginal cuff prolapse after hysterectomy. Fifty women will be randomly assigned to one surgery, and researchers will track recurrence, complications, recovery, and satisfaction. Th…

This study tests whether injecting platelet-rich plasma (PRP) into the vaginal tissue during pelvic organ prolapse surgery improves healing. Thirty postmenopausal women with moderate-to-severe prolapse will receive either PRP or a placebo injection during surgery. Researchers wil…

This study looks at whether adding a human amniotic membrane graft to standard mesh surgery can lower the risk of mesh exposure, a common complication. About 330 women with pelvic organ prolapse or stress urinary incontinence will take part. The goal is to see if the membrane hel…

This study tests whether adding a specific laparoscopic stitch (McCall suture) during a routine hysterectomy can prevent the top of the vagina from dropping later on (pelvic organ prolapse). About 114 women having a laparoscopic hysterectomy for non-prolapse reasons will be rando…

This study compares two approaches to pelvic floor rehabilitation after childbirth: one group works with a specialist using physiotherapy, biofeedback, and electrical stimulation, while the other group trains at home using a mobile app. Researchers want to see if these programs c…

This study tests whether virtual group counseling sessions help patients feel more prepared and satisfied before pelvic organ prolapse surgery, compared to standard individual phone calls. About 106 adults scheduled for surgery at Cleveland Clinic will fill out surveys before and…

This study looks at whether combining two types of pelvic floor exercises—functional movement retraining and hypopressive exercises—can reduce pain, improve bladder and bowel symptoms, and boost quality of life in women with mild uterine prolapse. Thirty-two women aged 30-60 with…

This study tests a new pessary that is custom-shaped to each woman's body for treating pelvic organ prolapse (POP). About 43 women who already use a standard pessary will try the new device for 3 months. The goal is to see if the custom fit improves comfort, ease of use, and symp…

This study compares two procedures—a sling or a bulkamide injection—to treat stress urinary incontinence in women who are also having vaginal prolapse repair. About 476 participants will be randomly assigned to one of the two treatments and followed for 24 months. The goal is to …

This study tests a new pessary system designed for easier home use in women with pelvic organ prolapse. About 200 women who have never used a pessary will be randomly assigned to either the new system or standard care. The main goal is to see if the new system leads to higher sat…

This study tests whether injecting a numbing medicine (bupivacaine) into the cervix area during vNOTES surgery can reduce pain afterward. 58 women with pelvic organ prolapse will receive either the numbing drug or a placebo (salt water). The main goal is to see if pain scores are…

This trial studies 88 women undergoing vaginal surgery for pelvic organ prolapse. Half will take senna pills and half will use bisacodyl suppositories after surgery. Researchers will measure how quickly each group has their first bowel movement and how satisfied they are with the…

This study tests whether adding hypopressive exercises to standard pelvic floor muscle training helps women aged 45-65 with mild pelvic organ prolapse. About 46 married, postmenopausal women with stage I or II prolapse will be split into two groups: one doing standard exercises a…

This study compares two ways of doing a common surgery for pelvic organ prolapse and stress incontinence. Doctors want to know if placing a small mesh sling before or after lifting the vagina leads to better bladder control and happier patients. About 110 women having robotic sur…

This study compares two types of laparoscopic pectopexy surgery for women with pelvic organ prolapse after hysterectomy. One method uses a mesh to support the vagina, while the other does not. The goal is to see which approach leads to fewer relapses and better quality of life, w…

This study compares a new energy-based surgical device (LigaSure Maryland) to the standard 'knot-and-cut' method for removing fallopian tubes and ovaries during vaginal hysterectomy for pelvic organ prolapse. Researchers will measure procedure time, blood loss, pain, and recovery…

This study is testing whether a remote, video-based pelvic floor muscle therapy program is easy to use and practical for patients with pelvic floor disorders like prolapse, incontinence, or bowel issues. Twenty participants will follow an 8-week online course at home. The main go…

This study tests whether a 6-week home exercise program (focused on relaxing and stretching the pelvic floor) can improve physical functioning after vaginal prolapse surgery. About 92 women aged 60-79 will be randomly assigned to either do the exercises or receive usual care. Res…

This study looks at whether a common surgery for pelvic organ prolapse can be performed without an overnight hospital stay. About 80 women with symptomatic prolapse will receive laparoscopic surgery with or without robotic help. The goal is to see if same-day discharge is safe an…

This study tests whether taking warm water sitz baths for 10 minutes each night for a week can reduce pain after pelvic organ prolapse repair. 112 women will be randomly assigned to sitz baths or standard care. The main goal is to measure pain intensity one week after surgery usi…

This study tests whether a numbing medicine injected around the cervix during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers afterward. About 56 participants will receive either the numbing medicine or a placebo (saltwater) inje…

This study is a long-term registry that will follow 1,000 women who receive pelvic mesh products for stress urinary incontinence or pelvic organ prolapse. Researchers will track how well the mesh works and any complications over 5 to 10 years. The goal is to gather real-world dat…

This study looks at how well a specific mesh (GYNEMESH PS) works for women who had surgery to fix pelvic organ prolapse. About 100 women will be checked roughly 7 years after their surgery to see if the repair is still successful. The goal is to gather long-term information on th…

This study follows 380 women for a year after vaginal delivery to see how pelvic floor muscles and tissues recover. It also tests whether early, personalized pelvic floor exercises can improve symptoms like urine leakage and pelvic organ prolapse compared to standard care. Partic…

This study looks at why some women develop stress urinary incontinence (leaking urine when coughing or sneezing) after surgery for pelvic organ prolapse. Researchers will follow 382 women who have no incontinence before surgery, using phone calls and questionnaires at 3, 6, and 1…

This study follows 288 women recovering from pelvic organ prolapse surgery. Participants wear a wrist accelerometer and complete a daily recovery questionnaire. Some receive routine recovery instructions, while others get an exercise-focused plan. The goal is to see which approac…

This study looks at how blood clots form and break down in women after surgery for uterine prolapse or urine incontinence. Researchers will measure clot properties and thrombin generation in 60 women aged 18-70 who did not improve with medication. The goal is to better understand…

This study looks at whether using ultrasound imaging and muscle activity sensors together can help women with weak pelvic floor muscles stick with their exercises and get better results. About 70 women will try different feedback methods during training. The goal is to find the b…