Pelvic organ prolapse

This study tests whether injecting poly-L-lactic acid (PLLA), a substance already used in cosmetic treatments, into the vaginal wall can safely and effectively treat cystocele (a type of pelvic organ prolapse). Twenty women with stage 2 cystocele will receive either PLLA or a pla…

This study will test a new mesh implant called ProGYNious for repairing pelvic organ prolapse in 100 women. The goal is to see how well it works and if it is safe. Participants will be followed for complications and quality of life after surgery.

This study tests whether adding a simple stitch to support the top of the vagina during a scarless hysterectomy (vNOTES) can help prevent pelvic organ prolapse later on. Fifty women having a vNOTES hysterectomy for non-cancer reasons will be enrolled. The surgeons will measure va…

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

This trial tests if leaving out vaginal gauze packing after prolapse surgery helps women recover faster. 360 women having surgery for pelvic organ prolapse will be randomly assigned to either receive standard packing for two hours or no packing at all. The goal is to see if skipp…

This study will follow over 1,000 women in Spain who are having vaginal surgery for pelvic organ prolapse. The goal is to see how often bladder control problems (like stress or urge incontinence) develop or improve after surgery. Researchers hope to find risk factors that can hel…

This study will use safe, non-invasive 2D and 3D ultrasound to measure pelvic floor changes in 185 women who have given birth. Participants will fill out a short questionnaire and have a pelvic exam. The goal is to compare findings between women who delivered vaginally and those …

This study looks at why women from ethnic minority backgrounds may not seek medical help for urinary incontinence or pelvic organ prolapse. Researchers will use questionnaires and interviews with 160 women to understand barriers like knowledge, embarrassment, or access. The goal …

This study will follow 200 women who are either taking GLP-1 weight loss drugs or undergoing bariatric surgery. Researchers want to see how these treatments change pelvic floor symptoms like incontinence and prolapse. Participants do not need to have any pelvic floor symptoms to …