Could a simple injection replace surgery for pelvic organ prolapse?
NCT ID NCT07544667
First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times
Summary
This study tests whether injecting poly-L-lactic acid (PLLA), a substance already used in cosmetic treatments, into the vaginal wall can safely and effectively treat cystocele (a type of pelvic organ prolapse). Twenty women with stage 2 cystocele will receive either PLLA or a placebo injection. The goal is to see if this non-surgical approach can strengthen vaginal tissue, reduce bulge symptoms, and improve sexual function, potentially offering an alternative to surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Poly-L-Lactic acid (PLLA, Sculptra) injection
- What this could lead to
- If it works, this could offer a non-surgical option to strengthen vaginal tissue and relieve bulge symptoms from cystocele, potentially improving sexual function and quality of life.
- What could go wrong
- This is a very small, early-stage trial with only 20 participants, so results may not apply to everyone. The treatment is not yet proven for this use, and there is a risk of side effects or no benefit compared to placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Duke Urogynecology, Patterson Place
Durham, North Carolina, 27710, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can simple exercises strengthen the pelvic floor? a study investigates
- Can a mesh implant fix a bladder bulge for good? a five-year checkup puts it to the test.
- Can a new mesh implant fix pelvic organ prolapse better?
- Can a virtual garden help women regain bladder control?
- New study tests which surgery works best for rectal prolapse in women
- Robot vs. vaginal surgery for prolapse: which is better? trial stopped early.