Pelvic organ prolapse
MONDO:0000082Abnormal descent of a pelvic organ resulting in the protrusion of the organ beyond its normal anatomical confines. Symptoms often include vaginal discomfort, dyspareunia; urinary stress incontinence; and fecal incontinence.
105 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Cross-Shaped device aims to ease pelvic organ prolapse
Disease control CompletedThis study tested a new, cross-shaped silicone pessary for women with pelvic organ prolapse. 51 women who already used a traditional pessary tried the new device for 6 months. Researchers measured symptom distress and how many women kept using it. The goal was to see if the new s…
Phase: NA • Sponsor: Dnipro State Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Which prolapse repair works best? new study compares One-Sided vs. Two-Sided surgery
Disease control CompletedThis study looked at 160 women with pelvic organ prolapse who had a hysterectomy and then one of two surgical repairs. The goal was to see if repairing one side or both sides of the supporting ligaments works better and is safer. Results may help doctors choose the best approach …
Phase: NA • Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Surgery showdown: which cystocele repair holds up best?
Disease control CompletedThis study compared two surgical techniques—laparoscopic sacropexy and vaginal mesh surgery—for repairing a cystocele (a type of pelvic organ prolapse). Researchers followed 220 women for four years to see which approach provided better symptom relief and fewer complications. The…
Phase: NA • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Mesh vs. laparoscopy: which surgery fixes bladder prolapse better?
Disease control CompletedThis study compared two surgical techniques for repairing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. The two methods were laparoscopic sacropexy (keyhole surgery using a mesh) and vaginal mesh surgery. The trial enrolled 262 women and l…
Phase: NA • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Robot-Assisted surgery for pelvic organ prolapse shows promise in small study
Disease control CompletedThis study tested the safety and effectiveness of a new robotic system (Dexter) for repairing pelvic organ prolapse in 35 women. The surgery aimed to restore support to the pelvic organs using a robot-assisted approach. The main goals were to see if the procedure could be complet…
Sponsor: Distalmotion SA • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Simpler surgery for pelvic organ prolapse may be just as effective
Disease control CompletedThis study tested whether a simpler version of laparoscopic surgery for pelvic organ prolapse works as well as the standard, more complex technique. 190 women with stage II-IV prolapse were randomly assigned to one of the two procedures. The goal was to see if the simpler method …
Phase: NA • Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Which mesh works best for prolapse? new study compares two options
Disease control CompletedThis study compared two different surgical meshes used to repair vaginal vault prolapse, a condition where the top of the vagina drops down. About 100 women having laparoscopic or robotic surgery received either Restorelle® Y mesh or Vertessa® Lite Y mesh. The goal was to see if …
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Which prolapse surgery is better? new study compares two fixation methods
Disease control CompletedThis study compared two surgical techniques to fix uterine or vaginal prolapse: sacrospinous ligament fixation (SSLF) and ischial spine fascia fixation (ISFF). Researchers wanted to see which method works better and improves quality of life more. The study included 76 women aged …
Phase: NA • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New 'Rug-Weaving' technique shows promise for bladder prolapse repair
Disease control CompletedThis study tested a new surgical method called the 'rug-weaving plication technique' for treating cystocele (bladder prolapse) in 60 women. It compared this approach to the standard repair surgery, looking at how well the bladder stayed in place and how satisfied patients were af…
Sponsor: Ankara City Hospital Bilkent • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Glue instead of stitches: new fix for prolapse surgery?
Disease control CompletedThis study tested a synthetic glue called IFABOND to attach surgical mesh during laparoscopic sacrocolpopexy, a surgery for pelvic organ prolapse. The goal was to see if using glue instead of staples or stitches reduces complications like vaginal erosion. 70 women with advanced p…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New graft shows promise for vaginal wall repair
Disease control CompletedThis study tested whether using a gamma-irradiated amniotic membrane as a graft during surgical repair of the back vaginal wall helps women with rectocele (a type of pelvic organ prolapse). Twenty-five women aged 30-60 underwent the surgery. The approach aimed to improve prolapse…
Phase: PHASE3 • Sponsor: Ain Shams Maternity Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Robot vs. surgeon: which surgery is safer for pelvic organ prolapse?
Disease control CompletedThis study compared two types of minimally invasive surgery for pelvic organ prolapse in 365 women. One group had robot-assisted surgery, while the other had standard laparoscopic surgery without a robot. The main goal was to see which approach had fewer complications within 30 d…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Which surgery works best for pelvic organ prolapse? new study compares two techniques
Disease control CompletedThis study compared two surgical methods—sacrospinous fixation and v-notes lateral suspension—for treating pelvic organ prolapse in 70 women aged 35-75. Researchers measured how well each surgery restored anatomy and improved quality of life. The goal is to find which approach of…
Phase: NA • Sponsor: Gaziosmanpasa Research and Education Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Mesh vs. no mesh: which bladder prolapse surgery holds up better over time?
Disease control CompletedThis study looked at 75 women who had surgery for bladder prolapse (a condition where the bladder bulges into the vagina). It compared two techniques: one using a mesh support and one without. The goal was to see which method works better over 5 to 8 years, focusing on whether th…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Mesh study aims to fix pelvic organ prolapse
Disease control CompletedThis study tested a special mesh (Uphold LITE) to treat uterine prolapse, a condition where the uterus drops into the vagina. 121 women received the mesh and were followed for 12 months. The goal was to see if the mesh could restore normal anatomy and relieve symptoms without nee…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Uterus-Saving surgery showdown: which fix works best for pelvic organ prolapse?
Disease control CompletedThis study compares two surgical techniques for pelvic organ prolapse that keep the uterus in place: vaginal sacrospinous ligament fixation and laparoscopic uterosacral ligament suspension. Researchers followed 111 women for up to two years after surgery, checking both symptoms a…
Sponsor: Hillel Yaffe Medical Center • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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New chair therapy vs. traditional exercises for pelvic support
Symptom relief CompletedThis study tested two non-surgical treatments for pelvic organ prolapse (POP) in 28 women: a special electromagnetic chair (HIFEM) and pelvic floor exercises with biofeedback. Both were compared to usual care (lifestyle advice). The goal was to see which approach better eases sym…
Phase: NA • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Could a simple girdle ease pelvic organ prolapse discomfort?
Symptom relief CompletedThis study tested a pelvic support girdle called FemmeJock in 100 women with pelvic organ prolapse. Participants wore the girdle during daytime physical activity for 3 months. The goal was to see if it improved symptoms like pelvic pressure and bulging, and whether women were sat…
Phase: NA • Sponsor: University of Oklahoma • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Could a simple laxative before surgery make recovery less painful?
Symptom relief CompletedThis study looked at whether taking a laxative (polyethylene glycol 3350) both before and after surgery helps reduce discomfort during bowel movements after pelvic prolapse repair. 74 women having minimally invasive surgery were randomly assigned to take the laxative before and a…
Phase: PHASE4 • Sponsor: University Hospitals Cleveland Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Packing or no packing? study questions routine practice after pelvic surgery
Symptom relief CompletedThis study looked at whether placing a vaginal pack after laparoscopic sacrocolpopexy (a surgery to fix pelvic organ prolapse) affects women's pain and satisfaction. About 250 women were randomly assigned to receive packing or not. The goal was to see if packing reduces complicat…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Own-Tissue surgery for prolapse shows promise in small study
Symptom relief CompletedThis study looked at whether a surgery called anterior sacrospinofixation, which uses a woman's own tissue instead of synthetic mesh, can improve symptoms of pelvic organ prolapse. 66 women with moderate to severe prolapse were followed for 2 months after surgery. The main goal w…
Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Less pressure, less pain? new study tests simple change during robotic surgery
Symptom relief CompletedThis study looked at 70 women having robotic surgery for pelvic organ prolapse. It compared standard gas pressure (15 mmHg) to a slightly lower pressure (12 mmHg) during the operation. The main goal was to see if the lower pressure led to less pain right after surgery, without ma…
Phase: NA • Sponsor: University of Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Toilet posture hack eases bathroom struggles for rectocele patients
Symptom relief CompletedThis study looked at whether using a special footstool to change your sitting posture on the toilet can make bowel movements easier for people with a rectocele (a type of pelvic organ prolapse). Sixty participants tried the device and rated their straining on a 0-10 scale. The go…
Phase: NA • Sponsor: TriHealth Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Nerve block may cut opioid use after pelvic surgery
Symptom relief CompletedThis study tested whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. 70 women were randomly assigned to receive either the QL block or standard enhanced recovery care. Researchers meas…
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Prolapse surgery without overnight stay? new study tests feasibility
Symptom relief CompletedThis study looked at whether laparoscopic promontofixation, a common surgery for pelvic organ prolapse, can be safely performed as an outpatient procedure. Sixty women who needed the surgery were discharged 8 hours after the operation. The main goal was to see how many needed to …
Phase: NA • Sponsor: University Hospital, Strasbourg, France • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Simple exercises after surgery boost pelvic health, study finds
Symptom relief CompletedThis study looked at whether pelvic floor muscle training can help women aged 40-60 who had gynecologic surgery for prolapse, fibroids, or hysterectomy. The goal was to reduce pelvic floor problems like incontinence and improve quality of life. 48 women took part, and the researc…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Pelvic organ prolapse surgery boosts sexual health and Well-Being
Symptom relief CompletedThis study looked at 31 women who had the Manchester operation for pelvic organ prolapse. The goal was to see how the surgery changed their sexual function and quality of life. Results showed improvements in both areas, suggesting this uterus-saving surgery is a good option for y…
Sponsor: Bagcilar Training and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Tiny bacteria, big impact: could vaginal microbes determine surgical success?
Knowledge-focused CompletedThis study looks at whether the types of bacteria living in the vagina influence how well women recover after surgery for pelvic organ prolapse using a vaginal mesh. Researchers will analyze stored samples from 41 women who had this surgery, comparing those who had complications …
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Study tests if women can take charge of their own pessary care
Knowledge-focused CompletedThis study looked at 176 women with pelvic organ prolapse to see if they were willing and able to manage their own vaginal pessary at home. Researchers asked about attitudes and tracked how many successfully learned to insert and remove the device. The goal is to understand what …
Phase: NA • Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Bladder leakage after prolapse repair: how common is it?
Knowledge-focused CompletedThis study looked at 609 women who had vaginal surgery for pelvic organ prolapse to find out how often they developed urinary incontinence afterward. Researchers measured stress and urgency leakage using questionnaires and also checked patient satisfaction. The goal was to better…
Sponsor: Hospital Universitari Vall d'Hebron Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New sexuality questionnaires tested for women with bladder or pelvic issues
Knowledge-focused CompletedThis study tested two French questionnaires about sexuality in 298 women who had surgery for urinary incontinence, pelvic organ prolapse, or fecal incontinence. The goal was to see if these questionnaires accurately measure sexual function compared to an existing tool. No treatme…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Prolapse surgery goes Same-Day: small study tests feasibility
Knowledge-focused CompletedThis study looked at whether surgery for vaginal prolapse can be safely done as a day procedure, allowing women to go home the same day. Thirty-eight women with advanced prolapse were treated at three hospitals in Lyon, France. The goal was to see how many could actually be manag…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:14 UTC