Can stem cell exosomes heal Radiation-Damaged bladders?

NCT ID NCT07665619

Not yet recruiting Disease control Sponsor: Fujian Medical University Union Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 4 times

Summary

This early-phase trial tests whether a combination of stem cell exosomes and sodium hyaluronate, instilled directly into the bladder, can safely treat radiation cystitis—a painful condition causing bleeding and urinary problems after pelvic radiotherapy. 48 women aged 18-80 will be randomly assigned to one of four groups: the combination, exosomes alone, sodium hyaluronate alone, or a saline placebo. Treatment is given once a week for 4 weeks, with follow-up at 1, 3, and 6 months to check bladder healing, symptoms, and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: human umbilical cord mesenchymal stem cell-derived exosomes combined with sodium hyaluronate
What this could lead to: If it works, this could offer a new treatment to repair bladder damage and reduce bleeding in people with radiation cystitis.
What could go wrong: This is a very early (Phase 1) trial with only 48 participants, so results may not apply to everyone. The treatment involves bladder catheterization, which carries infection and discomfort risks.

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Conditions

The condition(s) this trial relates to.

radiation cystitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RADIATION CYSTITIS

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