Can stem cell exosomes heal Radiation-Damaged bladders?
NCT ID NCT07665619
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether a combination of stem cell exosomes and sodium hyaluronate, instilled directly into the bladder, can safely treat radiation cystitis—a painful condition causing bleeding and urinary problems after pelvic radiotherapy. 48 women aged 18-80 will be randomly assigned to one of four groups: the combination, exosomes alone, sodium hyaluronate alone, or a saline placebo. Treatment is given once a week for 4 weeks, with follow-up at 1, 3, and 6 months to check bladder healing, symptoms, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
human umbilical cord mesenchymal stem cell-derived exosomes combined with sodium hyaluronate
What this could lead to
If it works, this could offer a new treatment to repair bladder damage and reduce bleeding in people with radiation cystitis.
What could go wrong
This is a very early (Phase 1) trial with only 48 participants, so results may not apply to everyone. The treatment involves bladder catheterization, which carries infection and discomfort risks.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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