Pressurized oxygen may heal radiation damage in cancer survivors

NCT ID NCT07422168

Completed Disease control Sponsor: Institute of Oncology Ljubljana Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. The goal was to see if the treatment could reduce tissue damage and be well tolerated.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber)
What this could lead to: If it works, this could offer a way to heal severe tissue damage caused by past radiation therapy, improving quality of life for cancer survivors.
What could go wrong: This is a small, completed study with no control group, so results may not be definitive. HBOT also has risks like ear pain or, rarely, lung injury.

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Conditions

The condition(s) this trial relates to.

osteoradionecrosis radiation cystitis radiation injury radiation proctitis radiation-induced disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RADIATION INJURY RADIATION NECROSIS RADIATION-INDUCED COMPLICATIONS

Contacts and locations

Locations

Institute of Oncology Ljubljana

Ljubljana, 1000, Slovenia

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