Radiation-induced disorder

This study tests whether taking pentoxifylline and vitamin E during chemoradiation can prevent lung injury (pneumonitis) in stage III non-small cell lung cancer patients. 150 participants will receive either the drug combo or a placebo for 6 months. The goal is to see if this red…

This study tests if the drug pirfenidone can help people with lung damage caused by radiation therapy (with or without immunotherapy). About 298 adults with certain cancers who received chest radiation will take pirfenidone or a placebo for 24 weeks. The goal is to see if the dru…

This study tests whether taking inhaled budesonide (a steroid) twice daily during radiation therapy can reduce the severity of radiation pneumonitis—a common and serious lung inflammation—in people with non-small cell lung cancer. About 72 patients will be randomly assigned to re…

This study tests whether using a SPECT scan to map healthy, working lung tissue can help doctors aim radiation away from those areas during treatment for advanced lung cancer. The goal is to reduce lung damage and side effects like breathing problems. About 90 people with lung ca…

This study tests whether a steroid (dexamethasone) given as an enema can help heal intestinal damage caused by radiation therapy in cancer patients. The trial will enroll 60 adults with moderate to severe acute radiation-induced rectosigmoid injury. Participants will receive eith…

Radiation for head and neck cancer can sometimes cause a serious side effect: dead bone in the jaw (osteoradionecrosis). This pilot study tests whether adding a drug cocktail called PENTOCLO to standard hyperbaric oxygen therapy helps more than oxygen alone. Twenty-four adults wi…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

This study is testing whether a special type of MRI (called DCE-MRI) can predict jaw bone damage (osteoradionecrosis) in head and neck cancer patients who have had radiation therapy. Researchers will scan up to 1,400 participants before, during, and after radiation to see if chan…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This study tests whether a chlorhexidine spray can prevent severe skin reactions caused by radiation therapy in people with nasopharyngeal cancer. About 148 participants will use the spray or a placebo during their treatment. The goal is to see if the spray reduces the chance of …

This study tests a cream called Pinoxin to see if it can prevent skin injuries caused by radiation therapy in cancer patients. About 202 adults receiving high-dose radiation will be randomly assigned to use either Pinoxin or a placebo cream. The main goal is to see if Pinoxin low…

This study tests a new cream made from amino acids to prevent skin damage caused by radiation therapy in people with head and neck cancer. About 40 participants will use the cream during their radiation treatment. The goal is to see if it reduces skin redness, pain, and treatment…

This study tests whether a gel containing diclofenac, a common anti-inflammatory drug, can prevent severe skin irritation caused by radiation therapy. About 156 adults with head/neck or breast cancer will apply the gel or a placebo to the treated skin three times daily during the…

This study tests a liquid made from cockroach extract (Meilian Fuxin) to prevent severe skin damage in head and neck cancer patients receiving radiation therapy. About 60 participants will apply the solution to their skin during treatment. The goal is to see if it reduces the ris…

This study tests a hydrogel made from bacterial cellulose and coconut oil monolaurin to prevent severe skin reactions in Filipino women with breast cancer undergoing radiation therapy. About 54 participants will apply either the hydrogel or a placebo cream daily. The goal is to s…

This study tests whether taking alpha lipoic acid, a common antioxidant supplement, can prevent or reduce skin irritation caused by radiation therapy in breast cancer patients. Researchers will enroll 40 women with early-stage breast cancer who are scheduled for radiation. The go…

This study tests whether a special light therapy can reduce skin damage caused by radiation treatment in women with breast cancer. 60 women who have had breast-conserving surgery and are scheduled for radiation will either receive standard skin care alone or standard care plus po…

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This study tests a new cream made from Prussian blue nanoparticles, combined with a special light therapy, to heal severe (grade III) radiation skin burns in head and neck cancer patients. The cream works by mopping up harmful molecules and, when activated by light, produces gent…

This study tests whether a special dressing (Mepilex Lite) placed inside the anal canal, combined with a pain-relieving suppository (indomethacin), can better treat acute radiation dermatitis—painful, red, or ulcerated skin—caused by radiotherapy for rectal cancer. About 274 adul…

This study tests whether a special light therapy called photobiomodulation (PBM) can reduce swelling and tissue hardening caused by radiation treatment in head and neck cancer survivors. Sixty participants who completed radiation at least 3 months ago will be randomly assigned to…

This study tests whether taking taurine granules before daily radiation can reduce painful mouth sores and skin burns in 160 head and neck cancer patients. Half get taurine, half get a placebo, and researchers track side effect severity. If effective, it could offer a simple, low…

This study tests whether N-acetyl cysteine (NAC) and a short course of steroids can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either NAC or placebo, plus either steroids…

This study tests whether a special imaging method (4DCT) can help doctors avoid giving too much radiation to healthy, working parts of the lung during radiotherapy for lung cancer. About 100 adults with lung cancer will receive standard radiation, but their treatment plan will be…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study uses repeated MRI scans after radiation therapy to see if they can predict normal tissue damage, like bone death (osteoradionecrosis), in patients with oral cavity or skull base tumors. Researchers will track changes in imaging over time and link them to radiation dose…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study will follow 150 people with radiation rectal injury to see if different subtypes of the condition lead to different outcomes. Researchers will collect medical records, endoscopy images, and test results but will not change any treatments. The goal is to fill gaps in kn…

This study looks at lung inflammation caused by radiation therapy for cancer, called radiation pneumonitis. Researchers will take cell samples from the lungs of 5 patients during a routine bronchoscopy and use a technique called single-cell sequencing to see which cells are activ…