Can MRI predict radiation side effects before they happen?

NCT ID NCT04265430

Recruiting now Knowledge-focused Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses repeated MRI scans after radiation therapy to see if they can predict normal tissue damage, like bone death (osteoradionecrosis), in patients with oral cavity or skull base tumors. Researchers will track changes in imaging over time and link them to radiation dose. The goal is to find early warning signs of injury, which could help doctors adjust treatment or intervene sooner.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors predict and prevent radiation-induced bone damage in cancer patients, improving long-term quality of life.
What could go wrong: This is an observational imaging study, not a treatment trial. It may not lead to direct patient benefits, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Mouth Neoplasms oral cavity cancer oropharynx cancer osteonecrosis of the jaw osteoradionecrosis skull base neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT ORAL CAVITY NEOPLASM MALIGNANT SKULL BASE NEOPLASM OSTEORADIONECROSIS

Contacts and locations

Locations

M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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