Could a common muscle drug and vitamin e heal jaw bone death?
NCT ID NCT03040778
First seen May 07, 2026 · Last updated Jun 22, 2026 · Updated 8 times
Summary
This phase 3 trial tests whether a combination of pentoxifylline (a muscle pain drug) and vitamin E can help heal jaw bone damage caused by osteoporosis or cancer treatments. About 100 people with medication-related jaw bone death will receive either the drug combo plus standard care, or standard care alone. The main goal is to see if the exposed bone area shrinks after one year.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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New York Center for Orthognathic and Maxillofacial Surgery
Lake Success, New York, 11042, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35242, United States
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University of Michigan
Ann Arbor, Michigan, 48109-0018, United States
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University of Washington
Seattle, Washington, 98195, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pentoxifylline and Vitamin E (tocopherol)
What this could lead to
If it works, this drug combination could become a non-surgical treatment to heal jaw bone damage caused by osteoporosis or cancer medications.
What could go wrong
This is a mid-stage trial with only 100 participants, so results may not apply to everyone. The drugs may not shrink the bone exposure better than standard care alone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.