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Could a common muscle drug and vitamin e heal jaw bone death?

NCT ID NCT03040778

Ongoing Disease control Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether a combination of pentoxifylline (a muscle pain drug) and vitamin E can help heal jaw bone damage caused by osteoporosis or cancer treatments. About 100 people with medication-related jaw bone death will receive either the drug combo plus standard care, or standard care alone. The main goal is to see if the exposed bone area shrinks after one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Pentoxifylline and Vitamin E (tocopherol)
What this could lead to
If it works, this drug combination could become a non-surgical treatment to heal jaw bone damage caused by osteoporosis or cancer medications.
What could go wrong
This is a mid-stage trial with only 100 participants, so results may not apply to everyone. The drugs may not shrink the bone exposure better than standard care alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

avascular necrosis Bisphosphonate-Associated Osteonecrosis of the Jaw osteonecrosis osteonecrosis of the jaw

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AVASCULAR NECROSIS BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW MEDICATION RELATED OSTEONECROSIS OF THE JAW

Contacts and locations

Locations

  • New York Center for Orthognathic and Maxillofacial Surgery

    Lake Success, New York, 11042, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35242, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109-0018, United States

  • University of Washington

    Seattle, Washington, 98195, United States

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