University Of Washington

This study is testing a combination of several chemotherapy drugs, with or without an antibody drug, plus a targeted pill called ponatinib. It aims to see if this approach is safe and effective for adults newly diagnosed with a specific, aggressive form of leukemia or lymphoma. T…

This study is testing a redesigned training program to help elementary school teachers better support autistic students with behavioral skills. Researchers will compare a new version of the program against the original to see if it's easier for teachers to use and if it helps imp…

This study is testing an 8-week exercise and education program designed to help people living with HIV improve their heart health. The program combines supervised gym sessions with home workouts and coaching to help participants become more physically active. Researchers want to …

This study is testing a combination treatment for very premature babies to see if it can safely reduce their need for blood transfusions and improve their iron levels and brain development. It will compare two forms of intravenous (IV) iron given with a drug called darbepoetin ag…

This study tests a mental health support program for adults hospitalized after serious injuries who show signs of PTSD. The program provides personalized care management, therapy, and medication options. Researchers want to see if this approach reduces PTSD symptoms and decreases…

This study is testing whether a surgically implanted brain device can help people regain arm and hand movement after a stroke. The device delivers mild electrical stimulation to the brain while participants do physical therapy, aiming to 'rewire' neural connections. It is a small…

This early-stage study is testing the safety of adding one or two new targeted drugs to a standard chemotherapy regimen for people with untreated, fast-growing B-cell lymphomas. The goal is to see if this combination is tolerable for patients and to gather initial data on its eff…

This study is testing if adding a drug called pacritinib to standard chemotherapy helps more patients with advanced blood cancers become eligible for a stem cell transplant. The goal is to better control the aggressive cancer so patients can safely receive the transplant. Researc…

This study is testing if giving very high doses of testosterone, along with chemotherapy or a targeted radiation drug, can help control advanced prostate cancer that has spread and stopped responding to standard hormone-lowering treatments. The idea is to shock cancer cells that …

This study is testing whether combining two drugs, pirtobrutinib and mosunetuzumab, works better for people with follicular lymphoma that has returned or not responded to previous treatments. The goal is to see if this combination can kill more cancer cells and potentially reduce…

This study is testing whether adding an experimental vaccine called WOKVAC to standard pre-surgery treatment can help the immune system better fight HER2-positive breast cancer. The trial will enroll 25 adults with early-stage breast cancer to receive the vaccine along with their…

This study is testing whether adding a new immunotherapy drug called epcoritamab to a standard chemotherapy regimen (EPOCH-R) is safe and more effective for treating aggressive B-cell lymphomas. The trial will enroll about 18 adults who have not yet received treatment for their s…

This study is testing a new treatment for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The treatment uses a radioactive drug that seeks out and attaches to prostate cancer cells to deliver radiation directly to tumor…

This study is testing whether smartphone apps can help people in Ghana manage schizophrenia. Researchers are comparing two different app-based support programs against standard care alone. The goal is to see if these digital tools can reduce symptoms like depression, anxiety, and…

This study is testing if a targeted drug called sacituzumab govitecan can help shrink tumors before surgery for patients with a rare and aggressive type of bladder cancer. The drug acts like a 'smart bomb,' attaching to cancer cells to deliver chemotherapy directly to them. The g…

This study aims to find the best way to prevent dangerous bleeding during and after childbirth for women with von Willebrand disease (VWD), a common bleeding disorder. It will test if giving a clotting factor replacement drug (Wilate) to keep blood clotting levels very high durin…

This study is testing whether adding three new immunotherapy drugs (tafasitamab, retifanlimab, and rituximab) to standard chemotherapy is safe and effective for people newly diagnosed with aggressive B-cell lymphomas. The trial will enroll about 35 adults to see if this combinati…

This study is testing whether two natural proteins from milk, lactoferrin and lysozyme, can help children who are recovering from severe diarrhea and malnutrition. The goal is to see if these daily supplements, mixed into food, can prevent future diarrhea episodes and help the ch…

This study is testing if adding a short course of the steroid dexamethasone to standard supportive care helps resolve painful bowel blockages caused by scar tissue from past surgeries. It will enroll 550 adults to see if the steroid treatment increases the chance the blockage cle…

This study is testing a drug called odronextamab to see if it can help control aggressive lymphoma long enough for patients to receive CAR-T cell therapy, a potentially curative treatment. The drug is given before the process to collect immune cells for CAR-T begins, with the goa…

This study is testing whether giving blood transfusions at a lower hemoglobin level (7 gm/dL) works as well as giving them at a higher level (9 gm/dL) for leukemia patients after chemotherapy or stem cell transplant. Researchers want to see if the lower level maintains patients' …

This study is testing a systems improvement strategy to better integrate HIV services into family planning clinics in Kenya. It aims to increase HIV counseling, testing, linkage to care, and access to prevention medication (PrEP), especially for adolescent girls and young women. …

This study is testing a new mobile health program designed to help young adults who use cannabis frequently. Participants will be randomly assigned to either use a program with personalized feedback and text messages for five weeks, or to receive standard online information about…

This study is testing if two advanced types of PET scans can help doctors see exactly where prostate cancer has spread after initial treatment. For men whose cancer has returned and spread to only a few spots, the scans will guide targeted treatment like radiation or surgery to t…

This study is testing a new, non-surgical method to help people pass kidney stones. Researchers are using focused ultrasound to try to break up stones and move them into a better position to pass naturally. The goal is to see if this can be done without the need for anesthesia or…

This small pilot study is testing whether giving copper supplements to people with advanced liver scarring (cirrhosis) is safe and can improve their health. It will involve 30 adult patients who have cirrhosis and low copper levels. Researchers want to see if raising copper level…

This study is testing whether a lower dose of the drug mosunetuzumab can effectively treat slow-growing B-cell lymphomas while potentially reducing side effects. The trial will enroll 20 adults with early-stage, low-tumor-burden lymphoma who haven't had prior treatment. Researche…

This study is testing a specialized radiation technique for patients with breast or lung cancer that has spread to the fluid around the brain and spine. The goal is to see if precisely targeting the entire brain and spinal cord with radiation, while avoiding a key memory area, ca…

This study is testing whether a blood test can safely reduce chemotherapy for people with advanced Hodgkin lymphoma. After two initial chemo cycles, patients with no detectable cancer DNA in their blood will receive less total treatment. The goal is to control the cancer while mi…

This study is testing a combination of chemotherapy drugs and a newer enzyme-blocking drug (JZP458) to treat adults newly diagnosed with a fast-growing blood cancer called acute lymphoblastic leukemia (ALL). The goal is to see if this combination can eliminate cancer cells more e…

This study is testing a new combination of cancer drugs for adults with aggressive forms of acute myeloid leukemia (AML) and related blood cancers that are newly diagnosed as high-risk or have come back after previous treatment. The goal is to find the safest and most effective d…

This study is testing whether a new vaccine called STEMVAC, when given alongside standard chemotherapy, can help control advanced triple-negative breast cancer. The vaccine is designed to teach the body's immune system to recognize and attack cancer cells. Researchers will enroll…

This study is testing whether a drug called loncastuximab tesirine can shrink tumors in adults with specific types of B-cell lymphoma that have come back or stopped responding to other treatments. The drug is designed to target cancer cells directly. Researchers will give the dru…

This study aims to understand why some men with advanced prostate cancer that has spread to bones respond better to the drug radium-223 than others. Researchers will test blood samples from 48 patients to look for specific DNA repair defects that might make the cancer more sensit…

This study is testing a new system designed to help people with opioid addiction continue their treatment after they are released from jail. It focuses on improving the handoff between jail-based care and community clinics to prevent relapse. The goal is to see if this coordinate…

This study is testing whether a vaccine called STEMVAC can help control advanced breast cancer that has spread. The vaccine is designed to boost the immune system to recognize and attack cancer cells. It's being given alongside standard hormone therapies or chemotherapy to 40 pat…

This study is testing if a new drug, SX-682, works better when given with an existing immunotherapy drug (pembrolizumab) for people with advanced non-small cell lung cancer that has spread or come back. The goal is to see if this combination can help the body's immune system figh…

This study is testing whether doctors can safely modify standard stent grafts on-site to treat dangerous aortic aneurysms in patients who have few other options. The research involves 500 patients with life-threatening bulges in their main artery near the kidneys. The goal is to …

This study is testing if adding a targeted drug called tafasitamab to a standard chemotherapy regimen works better for treating adults with a specific type of acute lymphoblastic leukemia (B-ALL). The trial aims to see if this combination can more effectively kill cancer cells an…

This early-stage study is testing whether adding a drug called abemaciclib to standard radiation therapy before surgery is safe and can help shrink tumors in patients with high-risk abdominal sarcomas. The trial will enroll 18 adults with this rare cancer to find the best dose an…

This trial is testing whether a combination of chemotherapy and targeted drugs can better prepare patients with advanced blood cancers for a stem cell transplant. The goal is to control the aggressive cancer enough so patients can safely receive donor stem cells, which may offer …

This study compares two approaches for treating recurrent high-grade bladder cancer that hasn't spread into the muscle wall. Researchers want to understand whether keeping the bladder with medication treatments or removing it surgically leads to better financial outcomes, quality…

This study aims to redesign a proven therapy for childhood trauma so it's easier for school counselors and social workers to use. Researchers will work with school providers and students to simplify the therapy's structure and make it fit better in a school setting. The goal is t…

This study is testing a special support program to help teenagers and young adults with HIV in Kenya successfully move from pediatric to adult healthcare. Researchers will compare two ways of introducing this program across 32 clinics to see which helps more young people stay in …

This trial is testing whether a targeted drug called gemtuzumab ozogamicin can eliminate hidden cancer cells in adults with acute myeloid leukemia (AML) who are in remission but still have measurable residual disease. The drug works like a guided missile—it attaches to specific m…

This study is testing a new type of PET scan to see if it can better show how well a patient's breast cancer is responding to certain targeted drug treatments. The scan uses a special tracer that lights up a specific protein in cancer cells. Researchers want to see if this new sc…

This study aims to find better ways to detect prostate cancer early in people who have a genetic risk for aggressive disease. Researchers will collect blood, urine, and tissue samples from 450 participants over three years to analyze and improve current screening tests. The goal …

This study is testing whether a 10-week parenting program delivered through video calls (telehealth) works as well as the traditional in-home version for families involved with child welfare services. Researchers will enroll 357 parents of infants (6-12 months old) to compare thr…

This study is testing a 12-week digital group program called IMAGINE, designed to prevent depression in people who are pregnant or recently had a baby and are at higher risk. It compares the program to standard care to see if it lowers depression scores and is easy and acceptable…

This study is testing two different mental health programs in Mozambican high schools to see which works better at preventing suicidal thoughts and behaviors in teenagers. It will involve about 2100 students who are experiencing suicidal thoughts. One program is a brief safety pl…

This study aims to find the best way to prevent common sexually transmitted infections (STIs) like gonorrhea and chlamydia among men who have sex with men in Kenya, where testing is often unavailable. It will compare two antibiotic approaches—taking medicine every three months ve…

This study tests if a text messaging service can help prevent newborn deaths in Kenya. It connects new mothers with community health workers through daily automated texts, allowing moms to ask questions and report danger signs between monthly home visits. The goal is to see if th…

This study is testing if a simple text-message system can help prevent malnutrition in young children exposed to HIV in Kenya. Caregivers receive weekly texts with feeding advice and are prompted to measure their child's arm to check for early signs of wasting. Researchers will c…

This study is testing a one-month online self-management program designed to help people who have recently received a shock from their implanted heart defibrillator (ICD). The program teaches heart rate monitoring and coping skills through web-based modules, with the goal of redu…

This study aims to find out if a common procedure for chronic low back pain, called lumbar radiofrequency ablation, actually works better than a fake procedure. Researchers will compare two different techniques for the nerve-zapping treatment against a simulated version in 300 pe…

This study is testing whether a personalized home exercise program delivered through a smartphone app can help people with early-stage bladder cancer become more physically active. Researchers will compare the app, which provides exercise videos and step goals, to a group that on…

This pilot study is testing whether a flexible, stepped care program is a practical and acceptable way to help people who have both chronic pain and PTSD. Researchers will compare this new approach to usual care in two primary care clinics. The main goal is to see if the program …

This study aims to figure out which specific parts of a proven talk therapy are most effective at reducing severe fatigue in people with multiple sclerosis (MS). Researchers will test three different therapy components—relaxation training, activity scheduling, and changing unhelp…

This study is testing whether a virtual exercise and wellness program can help reduce fatigue and improve symptoms for breast cancer patients undergoing radiation treatment. Participants will use activity trackers and try online classes like yoga, tai chi, and cardio. The goal is…

This study is testing if a personalized home exercise program, delivered through a smartphone app, can help people with bladder cancer get stronger before their surgery. About 128 patients will be randomly assigned to either use the exercise app or receive standard educational ma…

This study is testing a smartphone app designed to help teens and young adults (ages 13-21) who are having suicidal thoughts. The app helps them and their healthcare provider create a safety plan and provides videos with coping skills and support for both the youth and their pare…

This study is testing a new type of nerve block to reduce pain after skin graft surgery. It aims to numb the area on the thigh where skin is taken for the graft, but without causing leg weakness like older methods can. Researchers will carefully map the area that goes numb in 10 …

This study is testing if a simple, non-invasive therapy called ear acupressure can help improve appetite and prevent weight loss in people with certain advanced cancers. Researchers will recruit 66 patients with stomach, esophageal, or pancreatic cancer to see if applying small a…

This study aims to understand how stress in early childhood affects long-term health at a cellular level. Researchers will test whether a 10-week parenting support program, delivered at home and in a clinic, can reduce a mother's stress and improve her caregiving, potentially pro…

This study aims to understand why some people with social anxiety or body dysmorphic disorder don't fully benefit from cognitive behavioral therapy (CBT). Researchers will use brain scans, interviews, and questionnaires to track 160 participants during 12 weeks of therapy. The go…

This study is testing a web-based app called PST-Aid, which is designed to help therapists learn and consistently use a specific talk therapy for depression called Problem-Solving Treatment (PST). The researchers want to see if using this app helps therapists adopt the treatment …

This study is designing and testing a new smartphone app to help young adults (ages 16-30) who are experiencing suicidal thoughts. Researchers are working directly with patients and doctors to create the app, which asks users to check in about their mood and activities. The main …

This study follows men who have chosen 'active surveillance' for their low-risk prostate cancer, meaning they are closely monitored instead of immediately treated. Researchers will track 3000 participants over time with regular blood tests and biopsies. The main goal is to discov…

This study is testing whether a special type of PET scan can predict if a breast cancer drug called abemaciclib will work for patients with advanced hormone-positive, HER2-negative breast cancer. Researchers will give 60 participants this special scan before and after a brief hor…

This study aims to learn more about hemophilia A by following mother-child pairs from pregnancy through the child's early years. Researchers want to understand why some mothers with severe hemophilia have dangerous bleeding after childbirth and why some children develop antibodie…

This study aims to better understand the genetic causes of retinoblastoma, a rare eye cancer. Researchers will analyze DNA from 100 patients who have this cancer to learn how specific inherited mutations lead to the disease. The goal is to gather knowledge that could help future …

This study aims to understand why some people who have been treated for cancers like ovarian cancer later develop blood cancers or disorders. Researchers will observe 2,000 patients who have had certain cancer treatments to look for genetic and other risk factors. They will colle…

This study aims to understand if a specific gene mutation (HSD3B1) makes the breast cancer drug letrozole less effective. Postmenopausal women with early-stage, hormone-sensitive breast cancer will take letrozole for a few weeks before their standard surgery. Researchers will com…

This study aims to understand why some people develop gum inflammation quickly while others don't when plaque builds up. Healthy volunteers will stop cleaning certain teeth for 21 days so researchers can track how their gums respond. The goal is to identify the biological reasons…

This study collects blood and tissue samples from people with prostate or bladder cancer to learn why treatments sometimes stop working. Researchers will analyze these samples in a lab to look for genetic patterns and markers related to the cancer. The goal is to discover new tar…

This study aims to learn how advanced lung cancer responds to a combination of chemotherapy, immunotherapy, and radiation by closely watching changes on PET/CT scans. It will enroll 80 patients with stage IV non-small cell lung cancer who are starting this standard treatment. The…