University Of Washington

This phase II trial tests whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy drug carboplatin can prevent ovarian, fallopian tube, or primary peritoneal cancer from progressing after a blood test shows it may have returned. The study includes …

This phase 2 trial tested nivolumab, an immunotherapy drug, in 20 people with blood cancers like lymphoma, leukemia, or myeloma that came back or didn't respond after CAR T-cell therapy. The goal was to see if nivolumab could help the immune system attack the cancer again. The st…

This Phase 3 trial tested whether giving erythropoietin (Epo) soon after birth could reduce death or severe disability in extremely premature infants (born at 24-27 weeks). Over 900 babies were enrolled and followed until age 2. Unfortunately, Epo did not significantly lower the …

This study tested a combination of three targeted drugs (mosunetuzumab, polatuzumab vedotin, and obinutuzumab) in 42 people with untreated slow-growing B-cell non-Hodgkin lymphoma. The goal was to see how many patients achieved a complete response (no cancer detected). The drugs …

This pilot study tested whether giving a mix of glucose, insulin, and potassium (GIK) during abdominal surgery can reduce serious complications in patients who do not have diabetes. About 106 adults took part to see if the treatment is practical and safe. The goal is to plan a la…

This massive study tested whether giving deworming medicine (albendazole) to everyone in a community, not just children, can break the cycle of soil-transmitted worm infections. Over 350,000 people in India, Malawi, and Benin took part. The goal was to see if treating entire vill…

This completed study tested whether reducing loneliness through group therapy could lower opioid misuse in 102 adults on long-term opioids for chronic pain. Participants received either cognitive behavior therapy or social navigation in weekly sessions. Researchers measured chang…

This study tested whether a culturally tailored diabetes education program, called Compañeros en Salud, combined with a continuous glucose monitor (CGM) helps Latinx adults with type 2 diabetes control their blood sugar better than education alone. 120 adults aged 18-60 with an A…

This completed trial tested whether a clinical pharmacist team could reduce medication-related problems when adults move from a hospital to a skilled nursing facility. Over 1,000 patients took part. The pharmacist performed medication reviews, used a checklist for hand-offs, and …

This study tested a new combination of drugs for people with Hodgkin lymphoma that either returned after treatment or didn't respond. The goal was to find the safest dose of a targeted drug (brentuximab vedotin) when added to standard chemotherapy. 45 adults took part, and the st…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This phase 2 trial tested a combination of testosterone and olaparib in 36 men with castration-resistant prostate cancer. The idea is that testosterone can cause DNA damage in cancer cells that have adapted to low testosterone, while olaparib blocks the cells' ability to repair t…

This pilot study tested whether giving pembrolizumab (an immunotherapy) along with standard chemotherapy before surgery could help people with rare types of muscle-invasive bladder cancer. 17 participants received the combination, and researchers measured how many had no cancer l…

This study looked at how safe and effective a daily HIV prevention pill (TAF-FTC) is in 54 Kenyan cisgender women. Participants took different numbers of doses each week to mimic real-world use. The goal was to measure drug levels in the blood and tissues, helping doctors better …

This study looks at how often cisgender women in Kenya need to take the HIV prevention pill Truvada (TDF-FTC) to keep protective drug levels in their blood. Participants are randomly assigned to take 2, 4, or 7 doses per week for up to 16 weeks, and their drug levels are measured…

This study tested whether a Mediterranean-style diet could help prevent episodes of diverticulitis, a painful digestive condition. 71 adults who had recently recovered from a diverticulitis attack were randomly assigned to follow either a Mediterranean diet or standard high-fiber…

This study looked at different ways to help young women in South Africa, ages 18-25, take their daily HIV prevention pill (PrEP) consistently. The goal was to find the best support strategies to keep them protected from HIV. 360 women took part in the study, which tested a step-b…

This pilot study tested whether taking doxycycline once a week can prevent bacterial sexually transmitted infections (STIs) in cisgender women who are already taking HIV PrEP. Sixty women in Kisumu, Kenya, received the antibiotic weekly under direct observation for six months. Th…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study looked at whether offering HIV prevention services, including PrEP medication, in family planning clinics helps more young women get tested for HIV and start PrEP. Over 25,000 sexually active, HIV-negative young women in Kenya took part. The goal was to see if integrat…

This study tested a text-message chatbot called Cecebot that combines sleep therapy and activity tips to help breast cancer survivors with insomnia. 60 women with stage I-III breast cancer and poor sleep used the chatbot for 6 weeks. The goal was to see if it was easy to stick wi…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This study tested a web-based program for college women who experienced sexual assault and drink heavily. The program teaches skills to reduce alcohol use and manage emotions. 200 women participated, and researchers measured changes in their weekly drinking.

This study tested a new insulin dosing calculator for adults with type 2 diabetes when they are admitted to the hospital. The goal was to see if the calculator helps control blood sugar without causing dangerously low levels. Thirty-eight participants received their initial insul…

This study tested whether acupuncture can reduce pain and improve daily life for people with long COVID. 93 adults with persistent pain after COVID-19 were randomly assigned to receive 8 acupuncture sessions or continue their usual care. Researchers measured pain intensity and it…

This study looked at whether walking in nature reduces depressive symptoms more than walking in a city. 138 college students with mild to moderate depression were randomly assigned to take 30-minute walks twice a week for three weeks in either a natural or urban setting. Some nat…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study tested a mobile app designed to help people with chronic pain better manage their symptoms and reduce how much pain interferes with daily life. The app uses proven therapy techniques like Acceptance and Commitment Therapy and Cognitive Behavioral Therapy, plus tools to…

This study tested whether a smartphone app called FOCUS, along with coaching from trained clinicians, could help people with serious mental illnesses like schizophrenia and bipolar disorder. 191 participants used the app and received coaching over 12 weeks. Researchers measured c…

This study tested whether buffered lidocaine (lidocaine mixed with baking soda) reduces pain during prostate biopsy. 350 men undergoing a prostate biopsy received either buffered or standard lidocaine. Researchers measured pain from the numbing injection and from the biopsy itsel…

This study tested a program where pregnant people could text with a trained peer mentor for support. 127 participants in Washington state were split into two groups: one could text a mentor, the other got automated messages. The mentor group had lower anxiety six weeks after givi…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This study tested a web app called Rose that provides hypnosis audio recordings for people with chronic pain. 100 adults with chronic low back pain or other chronic pain used the app for 8 weeks. The researchers measured how often people used it, their satisfaction, and changes i…

This study tested whether using virtual reality (VR) can lower the pain people feel from short, hot but tolerable pokes on the skin. 24 healthy adults rated their pain with and without VR, and also when getting one poke versus two at the same time. The goal was to see if VR can b…

This study tested a single-session website called SPARK Coping in 50 college students at risk for psychosis. The goal was to see if it reduces distress, stigma, and improves attitudes toward treatment. Participants completed surveys at the start and two weeks later, with some get…

This study tested a program called PRISM to help adults with congenital heart disease build resilience and manage stress. 78 adults with moderate or complex heart conditions took part. Researchers checked if the program was feasible and if it improved resilience scores compared t…

This study tested a new type of prosthetic socket called the NU-FlexSIS for people who have a leg amputation above the knee and have limited mobility. The goal was to see if this socket is more comfortable and allows more wear time than the standard socket. 84 participants used b…

This study looked at whether three types of cognitive behavioral therapy (CBT) delivered online could help reduce fatigue in people with multiple sclerosis. 21 adults with MS and chronic fatigue tried relaxation training, behavioral activation, or cognitive therapy. The goal was …

This study tested two mobile health (mHealth) strategies to help people with schizophrenia manage their symptoms. 299 participants used smartphone tools to track and improve issues like depression, anxiety, and insomnia. The goal was to see if these digital tools could make a rea…

This study tested whether psilocybin, a substance from certain mushrooms, given with therapy could safely reduce anxiety and depression in 55 people with metastatic cancer. Participants received counseling and a pharmaceutical-grade psilocybin dose. The trial focused on safety an…

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. Th…

This phase 1 trial tested whether a second psilocybin-assisted group therapy retreat is safe and helpful for anxiety in 15 patients with metastatic cancer who had only a partial response to their first retreat. Psilocybin, the active ingredient in magic mushrooms, is given in a g…

This study looked at ways to help people who had a stroke use a CPAP machine for sleep apnea during their rehab stay. Sleep apnea is common after stroke and can slow recovery. The researchers tested different approaches to improve how often patients used the CPAP machine over thr…

This study tested whether Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) can reduce PTSD and depression symptoms in children aged 8 to 19 when delivered in schools. It also tested a strategy to help school clinicians adopt and stick with the therapy. The trial involved 292 …

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This completed study surveyed over 2,500 appendicitis patients to understand their satisfaction and regret after choosing either surgery or antibiotics. Researchers aim to use this information to design decision-support tools that help future patients make choices aligned with th…

This study looked at whether a rapid, point-of-care hepatitis C RNA test can help people who use syringe services get their test results and start treatment more quickly. Researchers offered the test to 200 clients at a syringe services program and tracked how many received resul…

This study tested whether oxytocin nasal spray helps people with social anxiety disorder learn safety from watching others. About 120 adults received either oxytocin or a placebo and underwent brain scans. The goal was to see if oxytocin improves the brain's ability to tell threa…

This study tested whether an AI scribe that listens to doctor-patient conversations can reduce doctor burnout and improve patient satisfaction. 139 doctors and advanced practice providers from primary care, oncology, and urology were randomly assigned to use the AI scribe or cont…

This study tested a parenting program for formerly incarcerated parents with children ages 2 to 12. The program combined behavioral parenting skills with mindfulness practices to support well-being and effective parenting. Researchers worked with re-entry navigators who had lived…

This study looked at how two hormones that rise during pregnancy—estradiol and cortisol—affect the way the body breaks down THC, the main active ingredient in cannabis. Fourteen healthy women of childbearing age took part. Researchers measured THC levels in the blood after taking…

This study looked at how young children with Down syndrome, cerebral palsy, and other motor delays move and explore when using a powered mobility device called the Explorer Mini and a bodyweight support system. Sixteen children who could sit upright but not walk 10 feet on their …

This completed study looked at how gender-affirming testosterone therapy changes the way the body processes other medications. Fourteen transgender adults who were about to start testosterone therapy took small doses of three common drugs (midazolam, digoxin, and acetaminophen) b…

This study tested whether a special ultrasound with a contrast agent (DEFINITY®) can measure blood flow in the spinal cord during surgery for acute spinal cord injury. 27 patients received the contrast agent while surgeons performed routine decompression. The goal was to see if t…

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study tested a 12-week home-visiting program called Promoting First Relationships® for birth parents who have been reunified with their young children (ages 1-5) after foster care. The program focuses on improving parenting skills and the parent-child bond. Researchers follo…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This study aimed to understand the challenges Spanish-speaking patients face when leaving the hospital for a nursing facility. Researchers interviewed 17 patients and caregivers to identify communication barriers and what helps or hinders a smooth transition. The goal is to use t…

This study looked at how stress influences the choice to drink alcohol in 160 regular drinkers. Participants were randomly assigned to stress or no-stress conditions and then completed a decision-making task choosing between alcoholic and non-alcoholic drinks. The goal was to und…

This study measured how much energy children with cerebral palsy use while walking, with and without harness support. 34 children aged 8-17 walked on a treadmill while researchers tracked their oxygen use and movement. The goal was to understand what makes walking so tiring for t…

This study tested whether online health messages and texts can help young adults (ages 18-24) who choose to drink have safer, more positive experiences. 35 participants in Washington State were randomly assigned to receive the messages or just fill out surveys. The main goal was …

This study looked at how gender-affirming estrogen therapy changes the way the body processes other medications. Twenty-two transgender adults who were not yet on estrogen took part. Researchers measured how two common drugs (midazolam and digoxin) were handled before and after s…

This study looked at how the brain naturally reduces pain when a person feels two painful sensations at the same time. Researchers tested 24 healthy University of Washington students by giving brief painful stimuli to the foot and wrist. The goal was to understand whether attenti…

This study looked at how alcohol changes attention in 92 young adults aged 21-25 who drink regularly. Participants completed simple phone-based tasks before and after drinking a standard amount of alcohol in the lab, and also answered surveys on their phones over eight weekends. …

This study tested a mobile app designed to help caregivers of young adults (ages 15-35) with early psychosis. The app provided interactive lessons to improve caregivers' knowledge and coping skills, aiming to reduce how long psychosis goes untreated. Sixty caregivers in the U.S. …

This study tested whether giving comic books and videos about COVID-19 safety to students and parents could reduce school absences due to illness. Over 1,000 people from rural Latino communities in Washington state took part. The goal was to see if simple educational materials co…

This study tested whether immersive virtual reality can distract people and affect their memory. Twenty healthy adults tried to remember words while in VR or while watching a plain video. Researchers also measured pain ratings during mild heat stimulation. The goal was to see if …

This study tested a mentoring program for women working in sheet metal construction. 96 female apprentices were paired with trained mentors to discuss workplace challenges and coping strategies. The goal was to see if mentoring reduces stress, harassment, and injury while improvi…

This study looked at how immersive virtual reality affects memory and distraction. 16 healthy adults tried to remember word lists while using VR or not. Researchers measured how many words they recalled and how distracted they felt. The goal was to learn more about how VR changes…

This study used MRI brain scans in twins to investigate whether brain inflammation (gliosis) plays a role in obesity and weight regain. Researchers compared people undergoing behavioral weight loss, bariatric surgery, and healthy-weight controls. The goal was to understand why we…