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Could giving TB meds at home boost prevention?

NCT ID NCT06214910

Completed Prevention Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HIV or close contact with TB patients. The goal was to see if community delivery leads to higher completion rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
isoniazid plus rifapentine (3HP)
What this could lead to
If successful, this approach could make it easier for people to complete TB preventive therapy, reducing tuberculosis cases in high-risk communities.
What could go wrong
This is a small, completed study focused on feasibility and completion rates, not on long-term TB prevention. Results may not apply to other settings or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease tuberculosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV I INFECTION TUBERCULOSIS

Contacts and locations

Locations

  • Human Sciences Research Council

    Sweetwaters, KwaZulu-Natal, South Africa

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