Testosterone therapy may change how other drugs work in the body

This completed study looked at how gender-affirming testosterone therapy changes the way the body processes other medications. Fourteen transgender adults who were about to start testosterone therapy took small doses of three common drugs (midazolam, digoxin, and acetaminophen) before and after starting testosterone. Researchers measured drug levels in the blood to see if testosterone altered how these drugs were absorbed and broken down. The goal is to help ensure safe and effective dosing for transgender individuals on hormone therapy.