Testosterone therapy may change how other drugs work in the body
NCT ID NCT05116293
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study looked at how gender-affirming testosterone therapy changes the way the body processes other medications. Fourteen transgender adults who were about to start testosterone therapy took small doses of three common drugs (midazolam, digoxin, and acetaminophen) before and after starting testosterone. Researchers measured drug levels in the blood to see if testosterone altered how these drugs were absorbed and broken down. The goal is to help ensure safe and effective dosing for transgender individuals on hormone therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
testosterone therapy
What this could lead to
If successful, this could help doctors adjust medication doses for transgender individuals on testosterone therapy, improving treatment safety and effectiveness.
What could go wrong
This is a very small, early-stage study with only 14 participants, so results may not apply to everyone. It only looks at how the body processes drugs, not whether testosterone therapy itself is safe or effective.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Washington
Seattle, Washington, 98195, United States