University Of Washington

This early-phase trial tests whether adding radiation therapy or bladder removal surgery can safely eliminate remaining cancer in patients with advanced bladder cancer who have already responded to a drug combination. The study enrolls 12 adults with muscle-invasive bladder cance…

This early-stage trial tests a drug called samuraciclib in 15 people with localized pancreatic cancer that can be surgically removed. Participants will take the drug for about two weeks before their planned surgery. Researchers will check safety and look for changes in tumor cell…

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This phase 2 trial tests whether combining SX-682 (a drug that blocks certain immune-suppressing proteins) with atezolizumab (an immunotherapy) can shrink tumors in people with advanced non-small cell lung cancer that has worsened after chemotherapy and immunotherapy. About 32 ad…

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

This phase II trial tests whether an IGFBP-2 vaccine, given after one dose of carboplatin, can stop ovarian cancer from growing in patients whose recurrence is detected only through a blood test. The vaccine helps the immune system target cancer cells, while carboplatin primes th…

This study tests a new approach to help young adults reduce harmful drinking. Participants can customize which peer groups they compare their drinking to, making the feedback more personal. The trial will enroll 250 University of Washington students who drink regularly and will m…

This study tests whether a family-based weight management program can slow the start of puberty in girls aged 6.5 to 8 years who have overweight or obesity. Half of the 240 girls will join a 20-session program focused on healthy eating and activity, while the other half receive u…

This trial investigates whether a special PET imaging tracer called [18F]FTT can help predict how well people with newly diagnosed bile duct cancer (cholangiocarcinoma) will respond to standard chemotherapy. The tracer binds to a protein called PARP1, which some tumor cells produ…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study will test whether offering HIV prevention medication, routine STI testing, and a preventive antibiotic at retail pharmacies helps young women avoid infections. About 720 women aged 15 to 24 who visit pharmacies for birth control will take part. Researchers will check h…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This study tests whether an internet-based program called My MS Toolkit can help reduce depression in people with multiple sclerosis. The toolkit teaches skills based on cognitive behavioral therapy to manage common MS symptoms like fatigue, pain, and low mood. Researchers will c…

This study tests a home-based exercise program called CAREFit-BMT for people with high-risk acute myeloid leukemia who are about to have a stem cell transplant. The program includes aerobic and strength training to improve heart function before the procedure. Researchers will enr…

This study tests whether the sleep aids doxepin and ramelteon can improve sleep quality during the first 6 weeks after total knee replacement. About 129 adults will be randomly assigned to take doxepin alone, doxepin plus ramelteon, or a placebo pill each night. The goal is to se…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study is developing and testing a brief online program for young adult couples (ages 18-29) who use both alcohol and cannabis. The program aims to reduce risky substance use and improve relationship skills. Sixty couples in Washington State will be randomly assigned to eithe…

This study tests whether adding estrogen to standard prostate cancer treatment can improve quality of life for 60 men with metastatic hormone-sensitive prostate cancer. Standard therapy often causes hot flashes and other side effects by lowering estrogen. The study compares estro…

This study will enroll 80 adults with multiple sclerosis and chronic pain to take part in an 8-week online Mindfulness-Based Cognitive Therapy (MBCT) program. Researchers want to understand what emotional, physical, and environmental factors make it easier or harder to practice m…

This study tests whether a package of coaching, feedback, and mentorship can help hospital teams in Kenya better review and respond to maternal and newborn deaths. Twenty facilities will take part, with half receiving the extra support. Researchers will measure if the approach im…

This study tests a new, non-invasive device that attaches to the outside of a prosthetic leg socket to measure how well it fits. Poor socket fit can cause pain, skin problems, and reduced mobility. The device tracks movement and accuracy as users perform a simple task, aiming to …

This study looks at the best ways to screen young children (16-24 months old) who were exposed to HIV for possible delays in brain development. Researchers will compare two screening methods used by healthcare workers during regular clinic visits in Botswana and Kenya. They want …

This study will enroll 1,260 pregnant women in Botswana, Kenya, and Zimbabwe to test a package of support that includes problem-solving sessions, infant feeding advice, and play groups. The goal is to see if these interventions improve child development and growth by age 2. Resea…

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easi…

This study tests whether a lead exposure prevention program originally designed for the US can work in Nairobi, Kenya. About 500 caregivers of children aged 1-6 will either get lead risk information only at a clinic or also receive a home visit with tailored advice. Researchers w…

This study looks at how feeling stressed and being with a friend influence people's decisions to drink alcohol. Researchers will have 160 regular drinkers choose between alcoholic and non-alcoholic drinks in different situations. The goal is to understand what drives drinking cho…

This study looks at whether adding a brief online personalized feedback program to standard screening and counseling can reduce impaired driving in young adults aged 18-30. Researchers will enroll 600 participants in Washington State who have already received standard screening. …

This study tests a mobile app called ALRITE that helps health workers in Uganda diagnose and manage breathing illnesses in young children. The app guides them through patient information and gives treatment recommendations. Researchers will see if using the app improves how often…

This study is developing and testing a program called Cannabis Conversation Skills for Families (CCSF) that teaches family members communication skills to encourage their young adult loved one with first episode psychosis to reduce cannabis use. The program includes education abo…