University Of Washington

This study tests a collaborative care model where pharmacists, doctors, and patient navigators work together to provide hepatitis C treatment to people who use drugs and live in supportive housing. 444 participants will be randomly assigned to either this model or usual care. The…

This phase 2 trial tests whether combining two drugs, SX-682 and pembrolizumab, can shrink tumors in people with advanced non-small cell lung cancer that has spread or come back. The study will enroll 30 adults whose tumors have a certain protein (PD-L1) and who have not had prio…

This study tests whether a simple text-message system can help caregivers in Kenya spot and prevent malnutrition in children exposed to HIV. About 776 caregiver-child pairs will be split into two groups: one gets weekly SMS reminders to measure the child's arm and receive feeding…

This phase 2 trial is testing a type of radiation called craniospinal irradiation that avoids the hippocampus, a brain area key for memory. It is for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if …

This early-phase trial is testing whether the drug abemaciclib, when given with radiation therapy before surgery, can safely shrink high-risk retroperitoneal liposarcomas. About 18 adults with this rare cancer will receive the combination to find the best dose and check for side …

This phase 2 trial is testing whether combining two drugs, pirtobrutinib and mosunetuzumab, can better treat follicular lymphoma that has relapsed or is refractory. Pirtobrutinib blocks a protein that helps cancer cells grow, while mosunetuzumab helps the body's immune T cells at…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study looks at whether giving very preterm infants extra sodium (based on blood and urine tests) helps them gain muscle and fat better than standard milk fortification. About 150 babies born between 24 and 31 weeks will be enrolled from three hospitals. Researchers will trac…

This study tests whether giving preterm babies (born before 32 weeks) a drug called darbepoetin plus a slow-release intravenous iron can reduce the need for blood transfusions, keep their iron levels healthy, and improve their brain development. About 120 infants will be enrolled…

This study tests whether adding a vaccine called WOKVAC to standard chemotherapy and targeted therapy before surgery can help the immune system better attack HER2+ breast cancer. About 25 adults with early-stage breast cancer will receive the vaccine alongside their regular treat…

This study tests a health system strategy called SAIA to improve care for people with opioid use disorder as they leave jail and connect to community clinics. Researchers will work with jail and clinic staff to identify bottlenecks and improve treatment continuity. The study invo…

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This study tests a combination of chemotherapy drugs (DA-EPOCH) plus an enzyme called asparaginase (Rylaze) in adults newly diagnosed with a fast-growing blood cancer (Philadelphia chromosome-negative ALL). The goal is to see if this mix can kill more cancer cells and achieve dee…

This study tests whether personalized text messages can help HIV-positive women in Africa who sell sex take their antiretroviral therapy (ART) regularly. 350 women will either get standard care or standard care plus text reminders and tips for six months. The goal is to see if mo…

This study is testing whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). Researchers will give 60 adults either valsartan or a placebo for 24 weeks to see if it improves how far they can walk in six minutes …

This study tests whether a non-invasive spinal cord stimulation device, used while exercising on an arm bike, can improve blood pressure and heart function in people with chronic spinal cord injury. Sixteen adults with paralysis at or above the T6 level will receive either real o…

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests whether giving the drug odronextamab before CAR-T cell therapy can help control aggressive large B-cell lymphomas that have returned or not responded to prior treatment. About 27 adults will receive odronextamab to slow disease progression and increase the chance…

This study tests whether disulfiram, a drug already approved for alcohol dependence, can improve vision in people with inherited retinal degeneration. The drug aims to block a harmful signaling pathway in the retina that worsens vision loss. Thirty adults with the condition will …

This phase 2 trial tests whether adding epcoritamab, a bispecific antibody that helps the immune system attack cancer cells, to standard chemotherapy (EPOCH-R) is safe and effective for aggressive B-cell non-Hodgkin lymphoma. About 18 patients with hard-to-treat forms of the dise…

This study tests adding venetoclax to a standard chemotherapy regimen (CLAG-M) for people with acute myeloid leukemia (AML) or related high-grade blood cancers. The goal is to find the safest dose and see if the combination improves cancer control. About 62 participants will take…

This phase II trial tests a combination of chemotherapy (DA-EPOCH) plus a targeted drug (ponatinib) in adults newly diagnosed with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL). The study will enroll 33 people to see if this approach leads to a complete …

This study tests whether short behavioral therapy sessions can improve sleep and reduce alcohol and cannabis use in young adults aged 18-29 who struggle with insomnia and heavy drinking or marijuana use. Researchers will enroll 800 participants in Washington State and compare tho…

This study tests a vaccine called STEMVAC, given with chemotherapy, for people with a type of advanced breast cancer (triple-negative) that has spread. The vaccine is designed to teach the body's immune system to find and destroy cancer stem cells. About 20 adults with PD-L1 nega…

This study tests a vaccine called STEMVAC in people with hormone receptor-positive, HER2-negative breast cancer that has spread. The vaccine is designed to help the immune system attack cancer cells. Participants will receive STEMVAC along with their usual hormone therapy, a targ…

This study tests a drug called 177Lu-PSMA-617, which delivers radiation directly to prostate cancer cells to damage their DNA. It is for people with prostate cancer that has spread and is no longer responding to hormone therapy. The goal is to see if this treatment can slow cance…

This study tests whether giving a chemotherapy drug (decitabine) plus a targeted therapy (ruxolitinib, fedratinib, or pacritinib) before a stem cell transplant helps people with advanced myeloproliferative neoplasms (MPN) get to transplant and have better outcomes. About 25 adult…

This phase II trial is testing whether a low dose of the drug mosunetuzumab can safely and effectively treat people with slow-growing B-cell lymphomas, like follicular and marginal zone lymphoma. The study will enroll 20 adults who have not had prior lymphoma therapy and have low…

This study tests whether copper supplements can improve liver function and safety in people with cirrhosis who have low copper levels. Researchers will give 30 participants either copper or a placebo and measure changes in blood copper levels and other health markers. The goal is…

This phase 2 trial is testing whether adding the drug pacritinib to standard treatments (azacitidine or decitabine) can help more people with advanced myeloproliferative neoplasms (MPN) get a stem cell transplant. The study will enroll 27 adults whose MPN has progressed to a more…

This phase 2 trial is testing whether a blood test that measures tumor DNA (ctDNA) can help doctors safely reduce the amount of chemotherapy for people with advanced Hodgkin lymphoma. After two cycles of standard chemo, patients with undetectable ctDNA may receive fewer total cyc…

This early-phase trial is testing whether adding the targeted drug polatuzumab vedotin (with or without another drug called glofitamab) to standard chemotherapy is safe for people with untreated, aggressive B-cell lymphoma. About 56 participants will receive the combination to se…

This study tests whether a targeted drug called gemtuzumab ozogamicin can clear tiny amounts of leukemia that remain after initial treatment in adults with acute myeloid leukemia (AML). The drug works like a smart bomb, attaching to a protein on cancer cells and delivering a chem…

This phase 2 trial tests whether giving high levels of testosterone alongside chemotherapy (carboplatin or etoposide) or a targeted radioactive drug (LuPSMA) can shrink tumors in men with advanced prostate cancer that has stopped responding to hormone therapy. The study will enro…

This study tests whether specially modified endovascular grafts can safely treat juxtarenal aortic aneurysms—a type of bulge in the main belly artery near the kidney arteries. The grafts are either modified by the doctor or made by a company, and are used in patients who have few…

This study looks at whether giving a medicine called Wilate to pregnant women with von Willebrand disease can prevent severe bleeding during and after childbirth. About 110 women will receive Wilate to keep their clotting factor levels high enough during delivery. The goal is to …

This study is for men with prostate cancer that has returned after surgery and radiation, but only shows up in a few places on a special PET scan. The goal is to treat those specific spots with targeted therapy, which may help control the cancer and delay the need for long-term h…

This study tests a new ultrasound device that can break kidney stones into tiny pieces and reposition them, all without anesthesia. Researchers will enroll 140 people with small kidney stones to see if the procedure is safe and helps stones pass naturally. The goal is to offer a …

This trial tests two strategies to control sexually transmitted infections (STIs) among 2,900 cisgender men who have sex with men in Kenya. One group gets a single dose of antibiotics every few months (WHO-recommended periodic presumptive treatment), another takes doxycycline wit…

This study tests a youth-led approach to help young people living with HIV in Kenya successfully move from pediatric to adult clinics. About 1,920 youth and their healthcare providers will take part across 32 clinics. The goal is to see if this strategy improves how many youth st…

This study tests whether daily supplements of lactoferrin and lysozyme, proteins found in milk, can prevent severe diarrhea and improve nutrition in children aged 6-24 months who were hospitalized with diarrhea and malnutrition. Six hundred children in Kenya will receive one of t…

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study tests a program called Our Value, which uses community health workers in small grocery stores to encourage fruit and vegetable intake among rural Latino adults. About 400 participants who shop at these stores will be compared to those at other stores to see if they eat…

This study tests whether safety planning and a type of talk therapy can reduce suicidal thoughts and actions in 2,100 secondary school students in Mozambique. Participants will be randomly assigned to receive one or both approaches, and researchers will track their progress over …

This study tests whether a mobile app called ExerciseRx can help people with axial spondyloarthritis (a type of arthritis affecting the spine and joints) exercise more and improve their symptoms. Forty adults who are not very active will either use the app for guided exercises an…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This study is testing an app called Jaspr that helps teens and young adults with suicidal thoughts create a safety plan and learn coping skills. The app includes videos and tools for teens, parents, and healthcare providers. Researchers want to see if using the app improves how w…

This study tests whether adding a short course of the steroid dexamethasone to standard supportive care helps more people recover from an adhesive small bowel obstruction without needing surgery. About 550 adults with this condition will be randomly assigned to receive either dex…

This study tests a new prosthetic socket that automatically adjusts to daily changes in limb size for people with below-knee amputations. The goal is to improve comfort, prevent skin problems, and reduce the need for manual adjustments. About 100 adults who have used a prosthesis…

This study tests whether a 12-week home walking program can improve daily activity and quality of life in people who have an implantable cardioverter defibrillator (ICD). Researchers will enroll 210 adults who can walk without help and have had an ICD placed to prevent sudden car…

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests a surgically implanted device called the CorTec Brain Interchange (BIC) System in 4 people who had an ischemic stroke at least 6 months ago and have lasting arm weakness. The device delivers electrical stimulation designed to encourage the brain to rewire itself …

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests an 8-week hybrid exercise program for people with HIV who are at risk for heart failure. Participants attend one supervised session at a center and do two unsupervised home workouts each week, plus receive education and coaching. The goal is to see if this approa…

This study tests whether relaxation training, activity planning, and cognitive therapy can reduce fatigue and improve daily functioning in adults with multiple sclerosis. About 112 participants will try these techniques via telehealth sessions. The goal is to find which component…

This study compares a home-based physical activity program delivered through the ExerciseRx app to health education alone in 100 adults with non-muscle invasive bladder cancer. Participants will use a Fitbit to track steps, and the app will set personalized goals and provide enco…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study aims to redesign Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) so it works better in schools. Researchers will work with school counselors and students aged 7-19 to make the therapy easier to use and more engaging. The goal is to help more young people get effec…

This study tests a stepped care approach that uses complementary health treatments (like acupuncture or yoga) for people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researchers want…

The ASTRAL study is testing whether radiofrequency ablation, a procedure that uses heat to quiet certain nerves, can reduce pain and improve function in people with chronic low back pain. Researchers will compare two types of ablation to a fake (sham) procedure in 300 adults. The…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This study tests a new type of nerve block called LAM for pain after skin graft surgery. The block aims to numb the thigh where skin is taken, without weakening the leg muscles. Ten adults having skin graft surgery will receive the block, and researchers will map how much sensati…

This study tests a 1-month self-management program for people who have recently received a shock from their implantable defibrillator (ICD). The program includes heart rate monitoring and online modules with phone coaching, aiming to reduce anxiety and prevent PTSD. 60 participan…

This study tests a coaching program called FIND-F, where home visitors film fathers playing with their young children (ages 12-36 months) and then review the videos to highlight positive interactions. The goal is to see if this approach improves fathers' supportive parenting and …

This study looks at two common treatments for a type of bladder cancer that keeps coming back: treatments that keep the bladder (like medicine placed directly into the bladder) versus surgery to remove the bladder. The goal is to see which option is better for patients' wallets, …

This study looks at how children with cerebral palsy (CP) adapt their walking when given feedback from a treadmill, sensors, and a wearable exoskeleton. Researchers want to understand how kids learn new movement patterns and whether training or surgery can improve their walking. …

This study looks at how mindfulness meditation and self-hypnosis work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to mindfulness, hypnosis, or story listening, and will undergo brain scans and E…

This study tests a short suicide prevention program for teens (ages 10-18) who have low to moderate suicide risk. The program is delivered in pediatric primary care clinics to make it easier for teens to get help. Researchers will check if doctors and families find the program us…

This study looks at how sleep helps clean the brain. Researchers will use special MRI scans to see the brain's waste-clearing system in 16 healthy young adults. They will also test a headband that tracks brain waves and uses mild electrical pulses to improve sleep and brain funct…

This study is testing a new radioactive tracer called [18F]FTT to see if it can help doctors see how well standard treatments are working in people with metastatic breast cancer. The tracer attaches to a protein in cancer cells and shows up on a PET scan. About 22 participants wi…

This study looks for better ways to find aggressive prostate cancer early in people who have a genetic risk. Researchers will collect blood, urine, and tissue samples from 450 participants to learn more about the genetics of this disease. The goal is to improve future screening a…

This study aims to improve how sexual and gender minority (LGBTQ+) individuals use digital mental health services. Researchers will test different messages and prompts on the Mental Health America website to see what encourages users to explore resources. About 2,300 participants…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study looks at whether stopping vaginal washing can lower inflammation in the cervix, which might help explain why this practice is linked to a higher risk of HIV. Researchers will measure immune cells and protective bacteria in 122 women who currently wash inside the vagina…

This study is testing a new center in Seattle where people who have had an opioid overdose can stay for up to 24 hours. The center offers monitoring, medication for opioid use disorder, and connections to ongoing care. Researchers will compare outcomes like repeat overdoses and t…

This study tests an online program called eBASIS designed to help school mental health providers feel more confident and motivated to use evidence-based practices. Researchers will compare providers who use eBASIS to those who don't, measuring changes in their attitudes and skill…

This study follows 2,000 people who have had ovarian or other solid cancers to learn why some later develop blood cancers like leukemia. Researchers will look at genetic changes in blood cells and treatment history to identify risk factors. No new treatments are being tested—the …

This study tests whether a special type of PET scan (FFNP-PET/CT) can predict how well a drug combination (abemaciclib plus hormone therapy) works in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 60 participants with metastatic or locally adva…

This study looks at the genes of 100 people with retinoblastoma, a rare eye cancer, to learn how changes in the RB1 gene cause the disease and related cancers. Participants give a blood or saliva sample for genetic testing. The goal is to better understand the link between a pers…

This study tests whether a 10-week parenting program called Promoting First Relationships works as well when delivered over Zoom as it does in person. About 357 parents of babies aged 6-12 months who are involved with child welfare will be randomly assigned to in-home sessions, t…

This study aims to understand why some people with social anxiety or body dysmorphic disorder respond fully to cognitive behavioral therapy while others do not. Researchers will use brain scans, thinking tests, and questionnaires to look for early signs of non-response. The study…

This study follows 500 mother-child pairs where the mother has a severe hemophilia A gene. It aims to understand bleeding risks during pregnancy and childbirth for mothers, and how children develop antibodies to factor VIII treatment. By observing families over time, researchers …

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer cells make the drug radium-223 work better or worse. The goal is to help doctors choose the best treatment for each patient in …

This study looks at whether giving blood transfusions only when hemoglobin drops below 7 gm/dL (instead of 9 gm/dL) is safe and maintains quality of life in leukemia patients after chemotherapy or stem cell transplant. About 50 adults with certain blood cancers will be randomly a…

This study tests whether a 10-week parenting support program (PFR-PC) can reduce stress in mothers and slow cellular aging in their infants. Researchers will measure telomere length and epigenetic age from blood samples of 250 mother-infant pairs from under-resourced families. Th…

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that may explain why some cancers stop responding to treatment. The goal is …

This study follows 3,000 men with early-stage prostate cancer who have chosen active surveillance (close monitoring instead of immediate treatment). The goal is to discover biological markers that can tell apart aggressive cancers from slow-growing ones. Researchers hope this wil…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation for stage IV non-small cell lung cancer. Researchers want to see if these scans can help predict how well the cancer responds to treatment. About 80 participants will undergo standard treatment al…

This study tests a two-way SMS system that lets pregnant women in Kenya text community health volunteers about their newborn's health. The goal is to see if this quick communication can reduce deaths in the first month of life. About 3000 women will take part, and the results cou…

This study is testing a smartphone app designed to help young adults aged 16 to 30 who are having suicidal thoughts. The app asks users to answer quick questions about their feelings and risks throughout the day. The goal is to see if the app is easy to use and helpful for both p…

This study looks at why people's gums respond differently to the buildup of dental plaque. Researchers will monitor 80 healthy adults aged 18-35 as they stop brushing for a period to allow plaque to grow naturally. The goal is to identify the biological reasons behind varying lev…

This study is testing a redesigned approach to help elementary school teachers use behavioral skills interventions for autistic children. Researchers will work with 160 participants to see if the new strategy is usable and effective. The goal is to improve access to evidence-base…

This study tests a web-based app called PST-Aid that helps clinicians guide patients through problem-solving therapy for depression. About 410 clinicians and their patients from community health centers will take part. The goal is to see if the app makes it easier for clinicians …