University Of Washington

This phase II trial tests a DNA-based vaccine called STEMVAC in 33 people with early-stage triple negative breast cancer (stages IB-III). The vaccine is designed to train the immune system to recognize and attack cancer cells that express certain proteins. Participants also recei…

This study looks at whether giving a smaller (one-fifth) dose of the HPV vaccine, either into the skin or muscle, can still trigger a strong immune response in adults aged 27 to 45. About 92 men and women in Seattle will have their antibody levels checked over a year. The goal is…

This early-stage trial tests a DNA vaccine called STEMVAC in 42 people with advanced HER2-negative breast cancer whose disease is stable or gone after standard treatment. The vaccine is designed to help the immune system recognize and attack cancer stem cells, which are often res…

This study tests a combination of two drugs, ixazomib and rituximab, in people with slow-growing B-cell non-Hodgkin lymphoma. The goal is to see how well the drugs shrink or control the cancer. About 33 adults with different types of this lymphoma are taking part.

This early-phase trial tests whether adding the drug acalabrutinib to CAR T-cell therapy can improve treatment for certain B-cell lymphomas. Acalabrutinib blocks cancer growth pathways, while the CAR T-cells are engineered to attack lymphoma cells. The study involves 23 adults an…

This study tests whether adding three targeted antibodies (tafasitamab, retifanlimab, and rituximab) to standard chemotherapy can safely treat people with untreated diffuse large B-cell lymphoma. About 35 adults will receive the antibody combination before and during chemo. The g…

This phase 3 trial tests whether the immunotherapy drug avelumab can keep Merkel cell carcinoma from returning in patients whose cancer has spread to lymph nodes and who have already had surgery or radiation. About 100 adults will receive either avelumab or a placebo every two we…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This phase 2 trial tests whether adding the targeted antibody tafasitamab to a standard chemotherapy regimen (DA-EPOCH, with or without rituximab) can improve outcomes for adults newly diagnosed with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL). Th…

This phase 2 pilot study tests whether giving brentuximab vedotin weekly, alone or with nivolumab, can help people with CD30+ lymphoma whose cancer stopped responding to the standard every-3-week dosing. The study enrolls 28 adults with relapsed or refractory Hodgkin or non-Hodgk…

This phase 3 trial tests whether a combination of pentoxifylline (a muscle pain drug) and vitamin E can help heal jaw bone damage caused by osteoporosis or cancer treatments. About 100 people with medication-related jaw bone death will receive either the drug combo plus standard …

This phase 2 trial tests whether combining golimumab (an anti-inflammatory drug) with apalutamide (a hormone blocker) can help men with castration-resistant prostate cancer that has spread. The study enrolled 8 participants and measures PSA reduction and tumor shrinkage. The goal…

This phase II trial tests a DNA vaccine called STEMVAC in 5 people with stage IV non-small cell lung cancer. The vaccine gives the body instructions to make parts of five proteins found on lung cancer cells, with the goal of activating immune cells to attack the tumor. Participan…

This phase 2 trial tests a combination of four drugs—isatuximab, carfilzomib, pomalidomide, and dexamethasone—in 30 patients with multiple myeloma that has relapsed or become resistant to treatment. The goal is to see how many patients respond to this regimen. All participants ha…

This study tests whether giving people with HIV same-day results from a simple urine test and a viral load test can help them stick to their medication and keep the virus under control. About 539 people starting HIV treatment in South Africa will take part. The goal is to see if …

This study tests whether text messages and counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,310 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This phase 2 trial tests the drug abemaciclib (Verzenio) in 20 patients with advanced gastroenteropancreatic neuroendocrine tumors that have spread, are not responding to treatment, and cannot be surgically removed. The drug works by blocking enzymes that help cancer cells grow. …

This study tests a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 12 adults with advanced Merkel cell carcinoma that continued to grow after standard treatment. The drugs are given by IV to help the immune system fight the cancer. The main…

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

This study tests a program called ED-LINC that starts in the emergency room for people with opioid use disorder. The program offers overdose education, motivation to seek help, help choosing medication, and three months of follow-up care. Researchers want to see if this approach …

This phase 2 trial tests the drug emicizumab (Hemlibra) as a regular injection to prevent bleeding in 51 adults with acquired hemophilia A, a rare condition where the immune system attacks clotting factors. Participants receive two loading doses then weekly shots, along with stan…

This study tests whether measuring blood pressure at home, rather than only at the dialysis center, helps prevent dangerous blood pressure drops during dialysis. 200 adults with end-stage kidney disease on dialysis will be assigned to either home or clinic blood pressure targets.…

This study is testing a short (under 5 minutes) MRI technique called DWI that does not require an injection of contrast dye. The goal is to see if it can find breast cancers that mammograms miss in women with dense breasts. About 269 women with dense breasts will participate. If …

This study tests whether a special PET scan using a tracer called 68Ga-PSMA-11 can find prostate cancer more clearly than standard scans. About 141 men with prostate cancer at different stages will get the scan. The goal is to see if the scan changes how doctors plan treatment, s…

This study tests whether new software for ultrasound machines can better detect and measure kidney stones compared to standard methods. Researchers will scan 370 adults with known calcium-based kidney stones and compare the results to CT scans and surgical findings. The goal is t…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests whether nurse-navigators can help adolescent girls and young women in Kenya start and continue taking PrEP, a daily medication that prevents HIV. About 1,900 participants will get PrEP at local pharmacies after buying birth control, and half will also receive ext…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This study is testing a package of tools—training for healthcare workers, quality improvement methods, and a community of practice—to help clinics in Kenya offer HIV prevention pills (PrEP) to pregnant and postpartum women. The goal is to screen more women and start them on PrEP …

This pilot study explores whether non-invasive electrical stimulation of the spinal cord, combined with hand and arm exercises, can improve upper limb function in people with multiple sclerosis. Participants use a home device with help from a partner over 8 weeks. The study focus…

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This study tests a 9-week virtual program that helps cancer survivors build social connections and reduce loneliness. Participants work one-on-one with a facilitator to create a personalized action plan. The goal is to see if this approach improves well-being and quality of life.

This study tests whether an autism-friendly mobile app can help children and teens (ages 8-17) with autism improve their toothbrushing skills and habits. Participants use either the special app or a basic control app for 3 months while researchers track brushing quality and habit…

This study tests a new mobile health program for young adults ages 18-29 who use cannabis frequently or use high-potency products. Participants receive personalized feedback and weekly text messages to reflect on their cannabis use and personal goals. The program aims to reduce t…

This study tests a device that uses focused ultrasound to gently push kidney stones, helping them pass or relieving pain. Researchers are enrolling 172 people with kidney stones, including those waiting for treatment or recently treated. The goal is to see if the ultrasound can m…

This pilot study tests whether a home-based virtual program of cardio and yoga (IM@Home) can help breast cancer patients undergoing radiation feel less fatigued and more active. Forty participants will wear a FitBit and attend online classes. The goal is to see if the program is …

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study tests whether a nurse care management program can help rural adults with chronic pain feel better and function more in daily life. The program includes care coordination, cognitive behavioral therapy, and referrals to an exercise program. About 450 rural patients will …

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study tests whether group or one-on-one peer support helps Black patients with endometrial cancer complete their treatment and feel less isolated. About 252 participants will be randomly assigned to group support, one-on-one peer calls, or usual care. The main goal is to see…

This early-phase study tests whether MDMA-assisted therapy can help people with pathological narcissism. Twelve adults will receive three monthly MDMA sessions plus therapy, with follow-up over six months. The goal is to see if symptoms improve and if the treatment is safe.

This study compares surgery (removing part of the colon) to the best medical treatments for people whose diverticulitis symptoms seriously affect their daily life. About 255 adults with at least one confirmed episode of diverticulitis and ongoing quality-of-life issues are taking…

This study tests whether sending brief, caring text messages over a year can reduce distress and suicidal thoughts in stressed or distressed U.S. veterans and service members. 521 participants receive either these caring contacts plus information about helpful resources, or just …

This study tests a special PET scan (FES) that tracks estrogen receptors in breast cancer tumors. Researchers want to see if changes in scan results before, during, and after hormone therapy can show how well the treatment is working. The study involves adults with estrogen recep…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This pilot trial tests an online decision support tool called Chart that helps local health departments assess heat-health risks and plan for extreme heat events. Thirty health departments will either use Chart or receive standard heat-health information. The study measures how w…

This study compares two common treatments for recurrent non-muscle-invasive bladder cancer: medical therapy (drugs placed in the bladder) and surgery (bladder removal). Researchers will track quality of life and patient experiences in 570 adults to see which approach works better…

This study looks at whether a simple urine pregnancy test taken 2 weeks after a medication abortion can reliably show the abortion is complete, instead of waiting the usual 4 weeks. About 400 people with very early pregnancies (up to 42 days) will take weekly tests and answer sym…

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to standard therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drug or d…

This study looks at how the Shingrix vaccine, which protects against shingles, affects immune cells in the skin and blood. Researchers will give the vaccine to 50 healthy adults in two age groups: 30-40 years old and 70 years or older. They will measure specific antibodies and T-…

This study is testing whether a smaller, one-fifth dose of the HPV vaccine, given into the skin instead of the muscle, can still trigger a good immune response in adults aged 27 to 45. Researchers are comparing two types of HPV vaccines in 40 volunteers in Seattle. The goal is to…

This study looks at 40 people with HIV to see if a common drug, tenofovir, causes more immune system activation and helps the virus hide better in the body. Participants are already on stable HIV treatment and will provide blood and gut samples. The goal is to find ways to reduce…

This study was designed to develop and test a new therapy model for young people aged 13-30 who have suicidal thoughts but don't need emergency care. The goal was to improve the bond between patient and therapist and reduce suicide risk. However, the study was withdrawn before en…

This study looks at whether a 20-minute writing task, called the Future Possible Self Task (FPST), can help high school seniors and recent graduates think differently about drinking and reduce alcohol misuse. About 468 participants will complete the writing exercise and answer qu…

This study looks at whether matching adults with chronic pain to specific psychological treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits (such as brain activity or thinking patterns) leads to better pain relief. Researchers wil…

This study tests two simple, scalable methods to help people with inherited cancer risk follow through on recommended screenings. Researchers will provide online educational resources and personalized phone outreach to 900 participants. The goal is to see if these approaches impr…

This study looks at whether a 20-minute writing task can change how college seniors view themselves as drinkers and help them drink less after graduation. About 468 students from two universities will complete the writing exercise and answer surveys over a year. Researchers hope …

This study looks at whether doing brain-training exercises in the morning or the afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit. Forty participants will either train in the morning, in the late afternoon/evening, or receive usua…

This study looks at whether advanced breast MRI can tell the difference between harmless and dangerous breast calcifications, which are often a sign of very early-stage breast cancer called DCIS. About 122 women with suspicious calcifications or recent DCIS diagnosis will get an …

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

This study tests whether a research website helps people with cystic fibrosis (CF) feel more prepared to discuss lung transplant with their doctors. About 132 adults with CF and low lung function will use the website and attend Zoom sessions over 6 months. The goal is to increase…