Cream test reveals how Alzheimer's risk gene alters Brain's response to fat
NCT ID NCT04692441
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This study investigates how a single high-fat meal (heavy cream) changes blood flow in the brain, and whether this effect differs based on a person's APOE gene variant — a known risk factor for Alzheimer's disease. Researchers will measure brain blood flow using MRI before and two hours after participants drink the cream. The goal is to understand why people with the APOE E4 gene, who are at higher risk for Alzheimer's, show a different brain response to dietary fat compared to non-carriers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Heavy cream (high-fat dairy)
- What this could lead to
- If it works, this could help explain why some people are more vulnerable to Alzheimer's after high-fat meals and point toward personalized dietary advice.
- What could go wrong
- This is a small, early-stage observational study, not a treatment trial. It only measures short-term changes in brain blood flow, not long-term disease outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
University of Washington Medical Center
Seattle, Washington, 98195, United States
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