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Braces without the spots: antiseptic solution may protect teeth during orthodontics

NCT ID NCT06616207

Prevention Sponsor: University of Washington Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests whether a topical 10% povidone-iodine solution can prevent white spot lesions on the front teeth of teens undergoing fixed orthodontic treatment. Healthy participants aged 10 to 17 will receive either the iodine solution or a placebo applied to all tooth surfaces at the start of treatment and again at 3, 6, and 9 months. Researchers will compare the development of white spots and gum health between the two groups over one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a topical 10% povidone-iodine solution applied to tooth surfaces
What this could lead to
If it works, this could offer a simple, low-cost way to prevent white spots on teeth for teens undergoing orthodontic treatment.
What could go wrong
This is a small, early-phase trial, so results may not apply broadly. The solution may cause staining or allergic reactions in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy children and teens (10-17 years old) * Transitional or permanent dentition of at least 4 permanent anterior teeth in each arch * Full fixed appliance orthodontic treatment is expected to last at least one year Exclusion Criteria: * Allergies to iodine * Chronic prophylactic use of antibiotics * Diagnosis of thyroid disease * Conditions that could impair routine oral hygiene procedures. * Pregnant at enrollment

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Conditions

The condition(s) this trial relates to.

gingivitis Hemorrhage enamel caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival inflammation and bleeding White spot lesions

Contacts and locations

Locations

  • University of Washington, School of Dentistry Department of Orthodontics, 1959 NE Pacific St. Health Sciences Center

    Seattle, Washington, 98195, United States

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