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Toothpaste that rebuilds enamel? a lab test pits bioactive glass against resin

NCT ID NCT07770724

Disease control Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This laboratory study compares two approaches for repairing white spot lesions—early signs of tooth decay—on extracted premolars. One method uses a bioactive glass toothpaste, while the other uses a resin infiltration treatment called ICON. Researchers will measure how well each method reduces lesion depth and restores enamel hardness, using scanning electron microscopy and microhardness testing. The goal is to see if a simple toothpaste could match or beat a dental procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bioactive glass toothpaste (Biomin F T/P) and resin infiltration (ICON)
What this could lead to
If effective, this could point toward a simpler, non-invasive way to repair early tooth decay and white spots, potentially reducing the need for drilling or fillings.
What could go wrong
This is a laboratory study on extracted teeth, not a clinical trial in people. Results may not translate to real-world use, and the effectiveness depends on how well these agents work in the mouth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Upper and lower premolars will be collected from patients undergoing extractions. * The teeth should be healthy with no carious lesions. * The crown and root morphology of teeth should be normal. * The extracted premolar teeth of patients should have no history of previous dental treatment. Exclusion Criteria: * • Fractured premolars due to any cause. * Loss of enamel due to parafunctional habits. * Presence of enamel anomalies (amelogenesis imperfecta, hypoplasia etc.). * Presence of stains, demineralization, decay, fluorosis and restorations

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

White spot lesions

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Islamic International Dental Hospital

    Islamabad, Capital, 44000, Pakistan

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