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Could a fluoride coating during braces prevent ugly white spots?

NCT ID NCT07691879

Prevention Sponsor: Sigmund Freud PrivatUniversitat Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests whether a fluoride-releasing adhesive used to attach braces can prevent white spot lesions—early signs of decay—on teeth. About 40 adolescents getting braces will have standard adhesive on one side of their upper jaw and the fluoride sealant on the other. After 3 months, researchers compare how many white spots develop on each side to see if the fluoride version offers better protection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fluoride-releasing bonding agent
What this could lead to
If effective, this fluoride sealant could become a simple, routine way to prevent white spot lesions during orthodontic treatment.
What could go wrong
This is a small, early-stage study with only 40 participants over 3 months. Results may not apply to all patients or longer treatment periods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy adolscents who are in need of orthodontic treatment.

Ages

10 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age between 10 and 17 years * Initiation of fixed orthodontic treatment in the upper jaw * Presence of all teeth 15-25 * Written consent from patients and legal guardians Exclusion Criteria * Pre-existing white spot lesions * Active carious lesions * Structural enamel defects * Systemic diseases affecting oral health * Vestibular restorations in the anterior region * Little Index \> 9

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Conditions

The condition(s) this trial relates to.

enamel caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

White spot lesions

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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