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Nature's tooth repair? peptide vs resin for Post-Braces white spots

NCT ID NCT07773714

Disease control Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial tests whether a self-assembling peptide (Curodont) can improve the color of white spot lesions that often appear after braces, compared to a resin infiltration treatment (ICON). The study involves 42 people aged 16-25 who have completed orthodontic treatment and have at least one white spot lesion. Participants will receive one of the two treatments, and the color change of the lesions will be measured to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Self-assembling peptide (Curodont Repair) applied topically to teeth
What this could lead to
If effective, this could offer a less invasive, natural way to reverse early white spot lesions after braces, potentially avoiding drilling or resin.
What could go wrong
This is an early-phase, small trial (42 participants). The peptide may not match resin infiltration in color correction, and results may not generalize to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

42 people

The number who actually took part.

Started

Apr 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * No systemic diseases or medication affecting salivary flow. * 16-25 years old. * Completed fixed orthodontic treatment. * Have one or more white spot lesions. * Good oral hygiene. * Co-operative patients approving the trial. Exclusion criteria: * Patients with Poor oral hygiene. * Xerostomia in which participants have evidence of reduced salivary flow. * Lack of compliance. * Participant in another trial. * Non carious lesion (enamel hypoplasia and dental fluorosis). * Presence of tetracycline pigmentation. * Filling on the labial surface.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

White spot lesions

Contacts and locations

Locations

  • Suez Canal University

    Ismailia, Ismailia Governorate, Egypt

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