Could a diabetes drug protect kidneys in type 1 diabetes?

NCT ID NCT05822609

Recruiting now Disease control Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in urine protein levels and kidney function to see if the drug helps protect the kidneys.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide
What this could lead to: If it works, this could point toward a new treatment to slow kidney damage in people with type 1 diabetes.
What could go wrong: This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. Semaglutide can cause side effects like nausea and vomiting, and its safety in type 1 diabetes is not fully known.

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Conditions

The condition(s) this trial relates to.

diabetic kidney disease type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC KIDNEY DISEASE TYPE 1 DIABETES

Contacts and locations

Locations

Providence Sacred Heart Medical Center
RECRUITING

Spokane, Washington, 99204, United States
Toronto General Hospital, University Health Network
RECRUITING

Toronto, Ontario, M5G2N2, Canada
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Washington
RECRUITING

Seattle, Washington, 98104, United States

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