TYPE 1 DIABETES

This study tests whether colchicine, a common anti-inflammatory drug, can improve how well the body responds to insulin in people with type 1 diabetes who have ongoing low-level inflammation. Researchers will measure insulin sensitivity using a special test in 26 adults. The goal…

This study is testing whether a 12-week high-fiber diet can help protect the beta-cells (the cells that make insulin) in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. The goal is to see if this dietary change can slow the loss of insulin production. Part…

This study tests whether the Medtronic 780G automated insulin delivery system can safely improve blood sugar control in 34 adults with type 1 diabetes who also have gastroparesis (stomach paralysis). Participants will use the system for a period, and researchers will measure time…

This study is testing whether a procedure called washed microbiota transplantation (WMT) can help people with type 1 diabetes better control their blood sugar and possibly reduce their daily insulin needs. Researchers will give 50 adults a transplant of processed healthy donor st…

This study tests whether taking a prebiotic fiber supplement for 6 months can help people with type 1 diabetes better control their blood sugar and reduce dangerous lows. The researchers will also look at how the supplement affects gut bacteria and gut health. The study involves …

This study follows 1,000 people with early-stage (Stage 2) Type 1 Diabetes who received teplizumab during regular doctor visits. Researchers want to see how long the treatment delays the onset of full-blown (Stage 3) diabetes and how it affects quality of life. The goal is to und…

This study is testing how well the Omnipod 5, an automated insulin delivery system, works in real-world conditions for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, qualit…

This study tests whether verapamil, a common blood pressure medicine, can help children aged 4 to 10 with recent type 1 diabetes keep making their own insulin. About 36 children will take verapamil or a placebo for 12 months, and researchers will measure insulin production and bl…

This study looks at whether changing how and when people with type 1 diabetes eat carbohydrates can improve blood sugar control. Researchers will track 80 adults over time using continuous glucose monitors. The goal is to find a simple dietary approach to reduce dangerous blood s…

This study tests whether the drug DFMO can help people with newly diagnosed type 1 diabetes keep making some of their own insulin. About 81 participants will take DFMO or a placebo twice daily for 6 months. Researchers will measure insulin production and check for side effects ov…

This study tests whether a two-step treatment can help young people with newly diagnosed type 1 diabetes keep making their own insulin. First, participants receive a low dose of anti-thymocyte globulin (ATG) to calm the immune system, followed by verapamil to reduce stress on ins…

This study tests a smartphone AI tool called Tia Bete that helps people with type 1 diabetes count carbohydrates and adjust their insulin doses in real time. Researchers will enroll 40 children and adults to use the tool for six months, measuring changes in blood sugar control an…

This early-stage study tests a new treatment called CELZ-201 for people recently diagnosed with type 1 diabetes. The goal is to see if it is safe and can help preserve the body's ability to make some insulin. The study involves 18 adults aged 18 to 35 who have had diabetes for le…

This study tests a new automated insulin delivery system called AIDANET in adults with type 1 diabetes. It compares three modes: fully automatic, hybrid (with some user input), and a mix. The goal is to see which mode keeps blood sugar in a healthy range more often. Participants …

This study tests a program for youth aged 10 to 13 with type 1 diabetes and their parents. The program helps families identify and build on the child's diabetes strengths to improve blood sugar control, daily management, and quality of life. About 250 participants will take part …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study tests a program called T1CARE that connects young adults with type 1 diabetes to a community health navigator who helps them resolve social needs like food, housing, or transportation. About 100 participants will be randomly assigned to get the navigator right away or …

This study tests a new drug called SAB-142 in people recently diagnosed with type 1 diabetes. The goal is to see if it can help the body keep making its own insulin longer, which may slow the disease. About 159 people aged 5 to 40 will take either the drug or a placebo, and resea…

This study compares a continuous glucose monitor (Dexcom G7) to standard finger-stick blood sugar tests in 100 hospitalized adults with poorly controlled type 1 diabetes. The goal is to see which method keeps blood sugar in a safe range (70-180 mg/dl) and prevents dangerously low…

This study tests a new system called AIDANET that uses a smartphone app to control an insulin pump and continuous glucose monitor for children aged 6-13 with type 1 diabetes. The goal is to see if the system is safe and works as well as their usual diabetes care. About 36 childre…

This study looks at how well the Omnipod 5 automated insulin delivery system works in daily life for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar in a healthy range and…

This study tests a 3-month program called Discovery Diabetes for teens and young adults (ages 13-21) with type 1 diabetes. The program uses personalized text messages and clinician support to help improve blood sugar control and reduce diabetes-related stress. Researchers will co…

This study tests a new smartphone-based system that automatically adjusts insulin delivery for people with type 1 diabetes. Six adults who already use insulin pumps will try the system for a short time under close supervision. The goal is to see if the technology works reliably a…

This study tests a new care model for 80 young adults with type 1 diabetes as they move from pediatric to adult healthcare. The model includes a nurse educator, psychologist, and transition navigator working together to address emotional and practical challenges. The goal is to i…

This study tests whether giving repeated BCG vaccines (a TB vaccine) can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were diagnosed with type 1 diabetes within the past year. Researchers will measure changes in HbA1c, C-peptide, and insulin u…

This study follows 120 children and teens with type 1 diabetes who are using the Medtronic 780G system, a closed-loop insulin pump that automatically adjusts insulin. Researchers want to see if the system improves blood sugar control and quality of life over two years. Participan…

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One method is strict (keeping blood sugar between 70-110 mg/dL) and the other is more relaxed (70-140 mg/dL). The goal is to see if the relaxed approach is just as safe for t…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can help preserve the cells that make insulin in adults newly diagnosed with type 1 diabetes. About 90 participants will take either the drug or a placebo twice daily for 24 weeks. Researchers…

This study tests a new medicine called CNP-103 in people aged 12 to 35 who were diagnosed with type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help preserve the body's ability to produce some insulin, reducing the need for lifelong insulin…

This study tests whether a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to 21 who were recently diagnosed with type 1 diabetes. The goal is to slow the loss of insulin-pr…

This study looks at whether adding a GLP-1Ra drug (like semaglutide) to teplizumab treatment helps people with early-stage type 1 diabetes manage their blood sugar and protect their heart health. About 24 participants aged 12-50 will have meal tests with and without the drug to m…

This study tests whether offering financial rewards helps teenagers with type 1 diabetes improve their blood sugar management. About 96 teens who use continuous glucose monitors will either get usual care or earn money for meeting self-care and glucose goals. Researchers will com…

This study tests a comprehensive management program for people with type 1 diabetes. The program includes a care team, technology, education, and peer support. Researchers will see if it helps improve blood sugar control and emotional well-being over one year. About 400 participa…

This study follows 200 people with stage 2 type 1 diabetes who are taking TZIELD, a drug that delays the disease from getting worse. The goal is to monitor long-term side effects like infections or allergic reactions. Participants are treated as part of their normal care, and res…

This study tests whether a closed-loop artificial pancreas system can improve blood sugar control and reduce heart disease risk in 40 adults with type 1 diabetes. Participants will use a continuous glucose monitor and insulin pump that work together automatically. Researchers wil…

This phase 3 study tests VX-880, a cell therapy, in 10 adults with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop taking insulin while staying on lifelong anti-rejection drugs. The study will measure insulin indepen…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This study checks if a combined test on a simple blotting paper (like a dried blood spot) can accurately detect type 1 diabetes in children. Researchers will compare results from the blotting paper test with standard blood tests in 106 children newly diagnosed with diabetes. If s…

This study tests whether a fingerstick glucose test done at home can accurately screen for type 1 diabetes, compared to the standard clinic-based oral glucose tolerance test. Researchers will enroll 60 people at risk for or recently diagnosed with type 1 diabetes. If accurate, th…

This study tests whether a special camera with artificial intelligence can help more young people with diabetes get screened for diabetic retinopathy, an eye disease that can lead to blindness. The study will include 500 underserved youth with type 1, type 2, or cystic fibrosis-r…

This study tests whether intensive diet and physical activity advice given to families from infancy to age 2 can protect the pancreas in children with a genetic risk for type 1 diabetes. About 1,244 infants will be randomly assigned to receive the counseling or standard care, and…

This study tests whether a specially designed digital game can help children aged 8-13 with type 1 diabetes improve their blood sugar control, confidence in managing their condition, and overall quality of life. About 58 children will play the game as part of their care. The goal…

This study tests an online training and support platform designed to help adults with type 1 diabetes better manage their condition. About 322 participants will use the platform for 12 months, either through their usual clinic care or on their own. Researchers will measure change…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have an eating disorder. About 235 people aged 16-50 will be assigned to ACT, supportive diabetes counseling, or a waitlist. The goal is to…

This study tests whether a telehealth program called REAL-Fam can help families in rural areas manage their child's type 1 diabetes. About 16 families will either receive 12 video sessions with an occupational therapist or just 3 check-in meetings. The goal is to see if the progr…

This study is testing whether a special type of talk therapy, delivered over video, can help young adults with type 1 diabetes who also struggle with anxiety or depression. The therapy includes reviewing blood sugar data from a continuous glucose monitor. Researchers will measure…

This study tests whether cognitive behavioral therapy (CBT) delivered online, along with a continuous glucose monitor, can reduce diabetes-related distress in adults with type 1 diabetes. About 93 participants will be randomly assigned to receive either CBT plus the monitor or th…

This study tests whether a daily tablet called sotagliflozin can improve quality of life for people with both type 1 diabetes and heart failure. About 320 adults in the UK will take either the drug or a placebo for 4 months, and researchers will measure changes in symptoms like b…

This study is testing a serious video game designed to improve emotional well-being in adolescents aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to adapt activities and feedback to each t…

This study tests a sleep-improvement program for 150 teens (ages 11-17) with type 1 diabetes who don't sleep enough and have high blood sugar. The program uses healthy sleep habits to help them sleep longer and more regularly. Researchers will check if better sleep improves blood…

This study tests a program called R2D2 that helps families of children with type 1 diabetes cope with the emotional stress of managing the condition. The program screens for diabetes distress and offers treatment to reduce that stress, with the goal of improving children's blood …

This study looks at how newer insulin delivery systems, like automated insulin pumps, affect eating behaviors in people with type 1 diabetes. Researchers want to see if these technologies reduce the burden of carbohydrate counting and lower the risk of disordered eating. About 10…

This study looks at how the time of day (circadian rhythm) affects blood sugar control during different types of exercise in teenagers with type 1 diabetes. Researchers will compare blood sugar levels during morning and afternoon workouts, including both steady and intense interv…

This study follows 550 people with stage 2 type 1 diabetes in the U.S. to see how teplizumab treatment affects their quality of life, anxiety, and diabetes burden. Some participants received teplizumab, others did not. Researchers will compare the two groups to understand real-wo…

This early-stage study looks at how a protein called C-peptide might help the liver release sugar during low blood sugar (hypoglycemia) in people with type 1 diabetes. About 38 adults with type 1 diabetes will take part to see if C-peptide can boost glucagon, a hormone that raise…

This study is testing whether it's practical to screen thousands of children for early signs of type 1 diabetes and celiac disease during their regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 and follow them for about 5 years. The goal is …

This study is exploring whether analyzing the chemicals in a child's breath can help detect or monitor diseases like asthma, brain disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to look for patterns linked to these cond…

This study looks at how being overweight affects insulin sensitivity and heart and muscle fitness in people with type 1 diabetes. Researchers will compare people with and without diabetes, before and after a high-intensity interval training program. The goal is to understand why …

This study looks at how certain genes affect the immune system and the risk of developing type 1 diabetes. Researchers will follow 2,800 people and track who develops the disease. No treatment is given; the goal is to better understand the disease process.

This early-stage study is testing a new concentrated insulin (U-500) given into the belly cavity in 25 adults with Type 1 Diabetes. The goal is to see if it is safe and how fast the body absorbs and uses it. Participants will have their blood sugar kept steady for 12 hours after …

This study screens children and teenagers (ages 1.5 to 18) who have a parent or sibling with type 1 diabetes. The goal is to find early signs of the disease, like specific antibodies in the blood, before any symptoms appear. Participants will have two visits over 13 months to che…

This study collects information from medical records of 60 people with stage 2 type 1 diabetes who received the drug teplizumab through special access programs. The goal is to describe their characteristics, such as age and family history, and track how their diabetes progresses …

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and compares them to healthy children. Researchers want to understand why the immune system attacks the pancreas by studying specific immune cells called CD4 T cells. The goal i…

This study aims to understand why people with type 1 diabetes have a higher risk of heart attacks and strokes. Researchers will compare how the body processes certain fats and proteins in 30 adults with and without type 1 diabetes. Participants receive a safe, labeled amino acid …

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way cells in the pancreas work in people with type 1 or type 2 diabetes. Researchers want to understand a natural hormone called GLP-1 that helps manage blood sugar. About 60 adults o…

This study is for post-menopausal women with type 1 diabetes. It will compare how aerobic exercise (like walking) and resistance exercise (like lifting weights) affect blood sugar levels compared to rest. The goal is to learn more about how different types of exercise impact gluc…

This study looks at how food, gut bacteria, and genetics affect blood sugar spikes in people with type 1 diabetes. About 200 participants will track their meals, provide stool and blood samples, and wear a continuous glucose monitor. The goal is to find patterns that could lead t…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the function of 'good' cholesterol (HDL) to normal levels. Researchers will compare 80 patients with poorly controlled diabetes who receive standard intensive therapy to 63 health…

This study looks at how reducing cholesterol changes blood cell activity and blood vessel function in 125 people with type 1 diabetes. Participants will have their cholesterol lowered and be monitored for one to two months. The goal is to learn more about heart disease risks in d…