TYPE 1 DIABETES

This study is testing whether giving the BCG vaccine (normally used for tuberculosis) twice, four weeks apart, can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were recently diagnosed with type 1 diabetes. The trial involves 100 participants a…

This phase 2 trial tests whether the drug DFMO can protect the body's remaining insulin-producing cells in people recently diagnosed with type 1 diabetes. About 81 participants will take either DFMO or a placebo twice daily for six months. Researchers will measure insulin product…

This study is testing whether a combination of two drugs, sotagliflozin and volagidemab, can improve blood sugar control in adults with type 1 diabetes. The 24 participants will receive both drugs or a placebo in a crossover design. The goal is to see if this approach can help ma…

This study tests a new program where schools, families, and doctors work together to help children manage type 1 diabetes. About 30 kids will take part to see if the program is practical and well-liked. The goal is to improve daily diabetes care at school.

This early-phase trial tests whether adding immune cells—either the patient's own regulatory T cells or donor bone marrow cells—to a standard islet transplant can improve blood sugar control in people with brittle type 1 diabetes. About 24 adults aged 18 to 70 will receive one of…

This early-phase trial tests VX-264, a therapy made from stem cells that produce insulin, in 7 people with long-standing type 1 diabetes. The goal is to see if it is safe and can help control blood sugar. If successful, it may reduce or replace the need for insulin injections.

This study tests a smartphone-based system called AIDANET that works with an insulin pump and continuous glucose monitor to automatically adjust insulin for children aged 6-13 with type 1 diabetes. The goal is to see if the system is safe and works as well as usual care in keepin…

This study tests whether adding two extra medications (semaglutide and dapagliflozin) to insulin helps adults with type 1 diabetes control their blood sugar better than insulin alone or with just one extra drug. The 78 participants, aged 18-70 with a BMI of 25 or higher, will be …

This phase 3 trial tests tirzepatide, a once-weekly injection, in 905 adults with type 1 diabetes who are also overweight or obese. Participants will receive either tirzepatide or a placebo for about 49 weeks. The study measures changes in blood sugar control (HbA1c) and body wei…

This study looks at whether remotely monitoring continuous glucose monitor (CGM) data can improve diabetes management in children within the first year after diagnosis. About 100 kids and teens newly diagnosed with type 1 diabetes will have their CGM data shared with their care t…

This study tests whether a transition coordinator can help 324 youth aged 17–18 with type 1 diabetes successfully move from pediatric to adult diabetes care. Participants get extra support before, during, and after the switch. Researchers will compare them to a group that didn't …

This study looks at whether doing light aerobic exercise five days a week can improve heart rate variability—a sign of heart health—in adults with type 1 diabetes. Over one year, 35 participants were split into two groups: one exercised regularly, the other less often. Researcher…

This study is testing whether a smartphone app called Glucosano, combined with help from a community health worker, can make it easier for Black children and young adults with type 1 diabetes to use advanced diabetes technologies like automated insulin delivery systems. The goal …

This phase 2 trial tests whether a probiotic called Lactiplantibacillus plantarum (Lp299v) can reduce inflammation and help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. The study includes 60 participants aged 3 to 45 who were diagnos…

This study compares a new diabetes-specific nutritional formula to an existing one in 103 adults with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. The goal is to see if the new formula is as good as the current one at improving nutrition, mea…

This pilot study is testing whether giving children (ages 6-17) newly diagnosed with stage 3 type 1 diabetes free weekly healthy foods and intensive nutrition counseling can help preserve their remaining insulin production. The study will enroll 20 children and measure how feasib…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 465 adults with type 1 diabetes who are also overweight or obese. Participants receive either tirzepatide or a placebo for about 20 months. The study measures changes in blood sugar control (HbA1c) and body weight …

This pilot study looks at whether adding a community health worker to the diabetes care team helps children recently diagnosed with type 1 diabetes. The health worker will visit the child's home, help set health goals, and address social needs like food or housing. The study will…

This phase 2 trial tests whether a daily low dose of colchicine, an anti-inflammatory drug used for gout, can reduce inflammation and heart disease risk in adults with type 1 diabetes. 102 participants aged 35–80 will take either colchicine or a placebo for 26 weeks, with an opti…

This study is testing a new continuous glucose monitor (CGM) called the iCan o3 in 70 adults with type 1 or type 2 diabetes. Participants will wear the device for 60 days to see if it improves their blood sugar control, especially the time spent in a healthy range. The goal is to…

This early-phase study tests a treatment called extracorporeal photopheresis (ECP) for people with type 1 diabetes. ECP filters and treats a patient's blood with light and a drug, then returns it to the body. The goal is to see if this approach can reduce the need for insulin inj…

This study tests a 10-lesson family cooking and diabetes education program called DICE for 32 youth aged 8-14 with type 1 diabetes who struggle with blood sugar control. The program aims to improve blood sugar management and reduce health disparities by teaching families practica…

This study tests whether metformin, a drug used for type 2 diabetes, can slow the buildup of calcium in leg arteries of people with type 1 diabetes. 230 adults will take either metformin or a placebo for two years. The goal is to see if metformin reduces artery hardening, which c…

This study looks at whether hybrid closed-loop systems (automated insulin pumps) can improve heart and blood vessel health in adults with type 1 diabetes. Researchers will compare these systems to standard insulin injections or added SGLT2 inhibitor drugs. They will measure arter…

This study is checking how safe and effective an updated insulin pump system (Control-IQ 1.5) is for children ages 2 to 6 with type 1 diabetes. About 144 kids will use the pump for a year while researchers track dangerous low blood sugar events and diabetic ketoacidosis. The goal…

This study tests a program called FAMS-T1D that helps young adults (ages 18-24) with type 1 diabetes set goals and get support from a friend or family member. The goal is to see if this approach improves blood sugar control, reduces diabetes distress, and helps the support person…

This study tests a program called FAMS that helps young adults aged 18-24 with type 1 diabetes use their continuous glucose monitor (CGM) more often. Participants include 140 CGM users who also have high blood sugar or diabetes distress. The goal is to see if the program reduces …

This study tests whether taking a probiotic supplement can reduce inflammation in children and teens (ages 5-17) recently diagnosed with type 1 diabetes. The goal is to see if changing gut bacteria can slow the disease's progression. Participants receive either a probiotic or a p…

This study tests whether a Bluetooth-enabled smart insulin pen, called InPen, can help teenagers with type 1 diabetes better control their blood sugar. The device helps calculate insulin doses and tracks injections, which may reduce errors. The trial involves 34 teens aged 13-21 …

This study aimed to transplant insulin-producing cells into the front chamber of the eye for people with type 1 diabetes and poor vision. The goal was to see if the procedure was safe for the eye. However, the trial was withdrawn before enrolling any participants, so no results a…

This study looks for tiny particles in the blood, called exosomes, that might signal the start of type 1 diabetes. Researchers will compare children recently diagnosed with type 1 diabetes to healthy children, all aged 12 to 18. The goal is to find a better way to catch the disea…

This study tests a home collection kit for people with diabetes to measure their HbA1c, a key blood sugar marker. 63 adults with Type 1 or Type 2 diabetes will use the kit and mail a dried blood spot to the lab. The goal is to see if the kit is accurate and easy to use, which cou…

This study tests whether a blood test for NT-proBNP can spot undiagnosed heart failure in 706 people with diabetes who are at high risk. Those with elevated levels get a heart ultrasound and exam. The goal is to see if this screening strategy leads to more early diagnoses and pro…

This study tests a mobile health program called R2D2 designed to reduce diabetes distress in children aged 8-12 with type 1 diabetes and their parents. The program uses cognitive behavioral therapy, mindfulness, and behavioral strategies to help families cope. Researchers will me…

This study tests whether cognitive behavioral therapy (a type of talking therapy) delivered online, along with a continuous glucose monitor, can reduce diabetes-related distress in adults with type 1 diabetes. About 93 adults aged 18-64 will be randomly assigned to receive either…

This study tests a remote education program called REST, designed to help adults aged 65 and older with insulin-treated diabetes start and keep using continuous glucose monitors (CGMs). The goal is to reduce dangerous low blood sugar episodes and improve overall glucose control. …

This study aimed to see if a corn-starch based drink taken before exercise could lower the risk of delayed low blood sugar in teens with type 1 diabetes. It also looked at whether it could improve biking performance. The study was withdrawn before enrolling any participants, so n…

This study looks at whether Swedish massage or yoga can help lower blood sugar levels in children with type 1 diabetes. About 50 children aged 6 to 12 from Cairo will take part. The goal is to see if these relaxing techniques can be a helpful addition to standard diabetes care.

This study looks at whether having a diabetes coach for 6 months can improve quality of life for families of children (16 or younger) recently diagnosed with type 1 diabetes. About 60 families will either get a coach or standard care. Researchers will check stress levels at 6, 12…

This study looks at whether a phone app called Happy Bob can help young people with Type 1 Diabetes feel more supported and manage their condition better. About 80 teens will use the app for 6 months and fill out surveys about their mood, quality of life, and how well they follow…

This study tests whether a self-help app called MyDiaMate can reduce diabetes distress in adults with type 1 diabetes. Researchers are enrolling 660 participants across the Netherlands, UK, Spain, and Germany. The app aims to support mental health alongside usual care.

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study looks at how often people with type 1 diabetes have fatty liver disease and serious liver scarring. Researchers used a special ultrasound and blood tests to check 533 adults. The goal is to find high-risk patients who need a liver specialist.

This study looks at why up to 40% of people with type 1 diabetes develop kidney disease, even with better blood sugar control. Researchers will use kidney biopsies and advanced imaging in 100 adults to find hidden risk factors like insulin resistance and inflammation. The goal is…

This study is screening 115 underserved children and adults who are at risk for type 1 diabetes or celiac disease. Researchers will use blood tests to find early signs of these conditions, aiming to improve how we detect them. The goal is to catch these diseases sooner, especiall…

This study looks at how well blood sugar is controlled and how diet relates to heart health in people with type 1 diabetes. Researchers will study 90 patients who use the MiniMed 780G insulin pump. They will measure blood sugar patterns, diet quality, and markers of heart and blo…

This study tests a program called SHIFT2 that helps teens and young adults with type 1 diabetes prepare for the switch from pediatric to adult medical care. Participants work with a transition coach and receive messages to encourage self-management. The goal is to see if this sup…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs from tiny particles in the blood. No treatment is given; …

This study looks at whether doctors can easily screen for sleep problems in teens with type 1 diabetes during regular clinic visits. About 50 teens who use a continuous glucose monitor will take part. The goal is to see how often doctors can complete the sleep discussion and foll…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study looks at whether continuous glucose monitors (CGMs) are practical for youth aged 2 to 26 with high blood sugar during hospital stays. Researchers will compare CGM readings with standard finger-stick tests and ask patients, families, and nurses about their experience us…

This study looks at differences in body composition, fitness, and temperature control during exercise between young soccer players with type 1 diabetes and healthy ones. Forty boys who have trained for at least 5 years will be monitored with thermal cameras and continuous glucose…

This study was designed to test whether group nutrition education on carbohydrate counting could improve blood sugar control in adults with type 1 diabetes or parents of children with the condition. Participants would have learned to count carbs with a team of experts. However, t…

This study tests a toolkit of short videos and online resources designed to help young adults (ages 18-30) with type 1 diabetes handle health insurance and financial stress. Researchers will track changes in financial stress, health insurance knowledge, diabetes quality of life, …

This study uses advanced MRI scans to measure the size and texture of the pancreas in people recently diagnosed with type 1 diabetes. Researchers hope to develop standard methods for assessing the pancreas, which could improve understanding of the disease. About 250 participants …

This study was designed to find out what parents of children aged 8-12 with type 1 diabetes need to better use insulin pumps and continuous glucose monitors. Researchers planned to use this information to create an app to support parents and improve diabetes management. However, …

This study tests whether wearable devices like continuous glucose monitors, Oura rings, and smart wristbands can predict how well the pancreas is working in people with type 1 diabetes. About 28 adults will use these tools at home for a short time. The goal is to develop remote m…

This observational study at the University of Texas at Austin will enroll 72 men and women with type 1 diabetes and healthy controls. Researchers will measure blood flow during exercise and monitor nerve activity to see how diabetes alters vascular and autonomic function. The goa…