TYPE 1 DIABETES

This study tests whether a once-weekly medicine called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. About 465 participants will receive either tirzepatide or a placebo for around 20 months. The main goals are to see if it improves blood sugar…

This study tests whether a daily probiotic supplement can reduce inflammation in children and teens newly diagnosed with type 1 diabetes. Researchers believe that changes in gut bacteria may worsen the disease. Participants take either the probiotic or a placebo for several month…

This study tests whether a transition coordinator can help 324 youth with type 1 diabetes (ages 17-18) successfully move from pediatric to adult diabetes care. Participants get extra support before, during, and after the switch. Researchers will compare them to a group that didn'…

This pilot study looks at whether adding a community health worker to the care team helps children (under 17) with newly diagnosed type 1 diabetes. The goal is to see if it improves blood sugar control, reduces hospital stays, and lowers healthcare costs. The study involves 28 ch…

This study aimed to test the safety of placing insulin-producing cells (islets) into the front part of the eye for people with type 1 diabetes. Only 6 participants were planned, all of whom needed lifelong immune-suppressing drugs. The study was withdrawn before any participants …

This study tests a new program called SPACE that brings together school nurses, parents, and diabetes doctors to help children with type 1 diabetes manage their condition at school. About 30 children will take part to see if this team approach is practical and well-liked. The goa…

This study tests a transition program for teens and young adults (ages 16-22) with type 1 diabetes as they move from pediatric to adult care. About 109 participants and their caregivers will use the program to improve blood sugar control, diabetes self-care, and clinic attendance…

This study tests a family cooking program called DICE for children aged 8-14 with type 1 diabetes who struggle with blood sugar control. The program teaches families how to cook healthy meals together, aiming to improve blood sugar levels and reduce health gaps. About 32 children…

This study tests whether a once-weekly medicine called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. About 905 participants will receive either tirzepatide or a placebo for about 49 weeks. The main goals are to see if it improves blood sugar c…

This study looks at whether hybrid closed-loop systems (smart insulin pumps) can improve heart and blood vessel health in adults with type 1 diabetes. One hundred participants with poorly controlled diabetes will be assigned to either a smart pump, an added diabetes pill, or inte…

This study watches 144 children aged 2 to 6 with type 1 diabetes who use the Control-IQ 1.5 system. Over 12 months, researchers track dangerous low blood sugar and diabetic ketoacidosis events. The goal is to make sure the technology is safe for everyday use in young kids.

This early-stage trial tests VX-264, a cell therapy designed to help people with type 1 diabetes who have had the condition for at least 5 years. The main goals are to check safety and see if the treatment can improve the body's own insulin production. About 7 participants will b…

This pilot study tests whether giving children (ages 6-17) with newly diagnosed stage 3 type 1 diabetes free healthy foods and intensive nutrition counseling, alongside standard insulin therapy, can prolong the 'honeymoon phase' and preserve beta cell function. The study enrolls …

This study looks at whether checking continuous glucose monitor (CGM) data remotely can help children and teens newly diagnosed with type 1 diabetes manage their condition better in the first year. About 100 participants will have their CGM data shared with their care team throug…

This study tests a program called FAMS-T1D for young adults aged 18-24 with type 1 diabetes. The program helps them set goals and get support from a friend or family member. Researchers want to see if it improves blood sugar control, diabetes management, and reduces diabetes-rela…

This pilot study tests a treatment called extracorporeal photopheresis (ECP) in 10 adults with type 1 diabetes. ECP filters and treats a patient's blood with light and a drug, then returns it, aiming to calm the immune attack on the pancreas. The goal is to see if ECP is safe and…

This study looked at whether doing light aerobic exercise five days a week for a year can improve heart rate variability—a sign of heart health—in adults with type 1 diabetes. Thirty-five participants were split into two groups: one exercised regularly, the other less often. Rese…

This study tests whether colchicine, a medicine used for gout, can lower inflammation and reduce the risk of heart disease in people with type 1 diabetes. About 100 adults with type 1 diabetes will take either colchicine or a placebo daily for 26 weeks, with an optional extension…

This study tests whether a Bluetooth-enabled smart insulin pen (InPen) helps teenagers with type 1 diabetes improve their blood sugar control. The device simplifies insulin dose calculations and tracks doses to prevent errors. Researchers will measure changes in HbA1c levels over…

This study tests whether metformin, a common diabetes drug, can slow or prevent calcium buildup in the leg arteries of people with type 1 diabetes. About 230 adults with type 1 diabetes and no serious kidney disease will take either metformin or a placebo for two years. Researche…

This study tests a program called FAMS that helps young adults (ages 18-24) with type 1 diabetes use their continuous glucose monitor (CGM) more regularly. Participants include 140 CGM users who also have high blood sugar or diabetes distress. The program involves support from fa…

This study looks at whether Swedish massage or yoga can help lower blood sugar levels in children aged 6 to 12 with type 1 diabetes. Both techniques are relaxing and may reduce stress, which can help control blood sugar. The study involves 50 children from Cairo who do not have o…

This study looks at whether a new computer program for doctors, a smartphone app for patients and parents, and a community health worker can help Black children and young adults with type 1 diabetes use advanced diabetes tools like continuous glucose monitors and automated insuli…

This study tests whether a probiotic called Lactiplantibacillus plantarum 299v can reduce inflammation and help preserve the body's ability to produce insulin in people recently diagnosed with type 1 diabetes. About 60 participants aged 3 to 45 will take the probiotic or a placeb…

This study aimed to see if eating a slow-digesting cornstarch snack before exercise could help teenagers with type 1 diabetes. The goal was to reduce the risk of dangerous low blood sugar after working out and to help them perform better during exercise. Teenagers would have trie…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study aims to find new biomarkers in the blood that could help diagnose type 1 diabetes earlier and track its progression. Researchers will measure tiny particles from insulin-producing cells in teens recently diagnosed with T1D and compare them to healthy teens. The goal is…

This study looks at whether having a personal diabetes coach for 6 months can improve quality of life for families of children (16 or younger) recently diagnosed with type 1 diabetes. About 60 families will either get the coach or usual care. Researchers will check stress levels …

This study looks at whether a phone app called Happy Bob can help young people with Type 1 Diabetes. About 80 teens will use the app for 6 months and fill out surveys about their mood, social support, and how well they manage their diabetes. The goal is to see if the app is easy …

This study tests whether a self-help app called MyDiaMate can reduce diabetes-related distress in adults with type 1 diabetes. About 660 participants from four European countries will use the app or receive usual care. The goal is to see if the app improves emotional well-being a…

This study tests an online toolkit designed to help young adults (ages 18-30) with type 1 diabetes manage health insurance and financial stress. About 195 participants across the U.S. will use the toolkit and complete surveys over one year. The goal is to see if the toolkit impro…

This study looks at whether doctors can easily screen teens with type 1 diabetes for sleep problems during regular clinic visits. About 50 teens who use a continuous glucose monitor will take part. The goal is to see how often the sleep discussion can be completed, not to test a …

This study looks for early signs of type 1 diabetes and celiac disease in children and adults who are at higher risk but may not have easy access to healthcare. Researchers will test blood samples for specific antibodies that signal the start of these conditions. The goal is to f…

This study tests a new digital tool for caregivers of children with type 1 diabetes. The tool tracks stress, mood, and blood sugar patterns to see if it's easy to use and helpful. 30 families will use the system for 2 months. The goal is to learn how stress affects diabetes manag…

This study looks at how type 1 diabetes changes blood vessel and nerve function in men and women. Researchers will measure blood flow and nerve activity during rest and exercise in 72 people with and without diabetes. The goal is to better understand the body's response to exerci…

This study aimed to see if group nutrition classes focused on carbohydrate counting could improve blood sugar control in people with type 1 diabetes. It planned to enroll adults and parents of children with type 1 diabetes who use insulin pumps or injections and continuous glucos…

This study aimed to find out what parents of children aged 8-12 with type 1 diabetes need to better use insulin pumps and continuous glucose monitors. The goal was to use this information to create a smartphone app to help parents manage their child's diabetes more effectively. T…

This study is creating a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genes and other markers to better predict who is at risk for serious complications like kidney failure, heart disease, and stroke…

This study looks at how often people with type 1 diabetes have nonalcoholic fatty liver disease (NAFLD) and serious liver scarring. Researchers used a painless ultrasound-like test and blood scores to check 533 adults at a diabetes clinic. The goal is to find high-risk patients w…

This study looks at 90 people with type 1 diabetes who use the MiniMed 780G insulin pump. Researchers want to see how well blood sugar is controlled and how that relates to heart and blood vessel health. They will also check if following a Mediterranean diet makes a difference. T…